Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia

Autor: Colleen Lopez, William Fuller, Jack J. Miller, Kieran Clarke, Georgina Berridge, Roman Fischer, S Rohling, K.M.J.H. Dennis, C.L. Aitken, Matthew Kerr, Carolyn A. Carr, Lisa C. Heather, Damian J. Tyler

Publikováno v: The FASEB Journal
Kerr, M, Dennis, K M J H, Carr, C A, Fuller, W, Berridge, G, Rohling, S, Aitken, C L, Lopez, C, Fischer, R, Miller, J J, Clarke, K, Tyler, D J & Heather, L C 2021, ' Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia ', FASEB Journal, vol. 35, no. 8, e21765 . https://doi.org/10.1096/fj.202100394R

The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischemia provides a pathological setting in whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9291e196f652495888da50c5d314b9a2
https://doi.org/10.1096/fj.202100394r

Context-dependent regulation of endothelial cell metabolism:differential effects of the PPARβ/δ agonist GW0742 and VEGF-A

Autor: Caroline P.D. Wheeler-Jones, Nicole Wagner, Ashton Faulkner, Coleen Jones, Mary Board, Kay-Dietrich Wagner, Eleanor Lynam, Carolyn A. Carr, Colleen Lopez, Robert Purcell

Publikováno v: Faulkner, A R M, Lynam, E, Purcell, R, Jones, C, Lopez, C, Board, M, Wagner, K, Wagner, N, Carr, C & Wheeler-Jones, C 2020, ' Context-dependent regulation of endothelial cell metabolism : differential effects of the PPARβ/δ agonist GW0742 and VEGF-A ', Scientific Reports, vol. 10, no. 1, 7849 (2020) . https://doi.org/10.1038/s41598-020-63900-0
Scientific Reports
Scientific Reports, 2020, 10 (1), pp.7849. ⟨10.1038/s41598-020-63900-0⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.7849. ⟨10.1038/s41598-020-63900-0⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Peroxisome proliferator activated receptor β/δ (PPARβ/δ) has pro-angiogenic functions, but whether PPARβ/δ modulates endothelial cell metabolism to support the dynamic phenotype remains to be established. This study characterised the metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48869a050350e5ba1b5affb184e1660
https://research-information.bris.ac.uk/en/publications/b4dea565-22da-4c68-ba66-a60406451ccb

Changing metabolism in differentiating cardiac progenitor cells - can stem cells become metabolically flexible cardiomyocytes?

Autor: Carolyn A. Carr, Sophia Malandraki-Miller, Colleen Lopez, Heba Hussain A. A. Al-Siddiqi

Publikováno v: Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 5 (2018)

The heart is a metabolic omnivore and the adult heart selects the substrate best suited for each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand of the contracting myocardium. The fetal heart exists in an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30a4b42e61a7b59f08ff262b8021380
http://ora.ox.ac.uk/objects/uuid:

Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species

Autor: Mary, Board, Colleen, Lopez, Christian, van den Bos, Richard, Callaghan, Kieran, Clarke, Carolyn, Carr

Publikováno v: The International Journal of Biochemistry & Cell Biology

Graphical abstract Energy yielding pathways of human mesenchymal stem cells Glucose is consumed by both the glycolytic and the oxidative pathways. Pyruvate, acetoacetate and glutamine are oxidised by hMSCs. Exogenous substrates are shown in boxes wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bd32cc5714f31c2fd2a7863b798261b
https://pubmed.ncbi.nlm.nih.gov/28483672