Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Colleen Kuemmel"'
Autor:
Daphney Jean, Kunal Naik, Lauren Milligan, Stephen Hall, Shiew Mei Huang, Nina Isoherranen, Colleen Kuemmel, Paul Seo, Million A. Tegenge, Yaning Wang, Yuching Yang, Xinyuan Zhang, Liang Zhao, Ping Zhao, Jessica Benjamin, Kimberly Bergman, Joseph Grillo, Rajanikanth Madabushi, Fang Wu, Hao Zhu, Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1271-1275 (2021)
Externí odkaz:
https://doaj.org/article/857bb5cce86240bba8f4309aa783564a
Autor:
Colleen Kuemmel, Yuching Yang, Xinyuan Zhang, Jeffry Florian, Hao Zhu, Million Tegenge, Shiew‐Mei Huang, Yaning Wang, Tina Morrison, Issam Zineh
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 21-28 (2020)
The use of computational models in drug development has grown during the past decade. These model‐informed drug development (MIDD) approaches can inform a variety of drug development and regulatory decisions. When used for regulatory decision makin
Externí odkaz:
https://doaj.org/article/d37d81d3f5484d88b5b2a2b282604b5b
Autor:
Hao Zhu, Xiaomei Chen, Mariam Ahmed, Yaning Wang, Qi Liu, Ramana S. Uppoor, Colleen Kuemmel, Mehul Mehta
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 564-572 (2019)
In this paper, a special case for bioequivalence evaluation of oral formulations is discussed. Drug formulations with different forms of active moieties (e.g., free base and salt) may yield different dissolution characteristics and, thus, differ in a
Externí odkaz:
https://doaj.org/article/443da419369d4b16acaa64921e057309
Autor:
Rajanikanth Madabushi, Daphney Jean, Paul Seo, Yaning Wang, Liang Zhao, Issam Zineh, Hao Zhu, Joseph A. Grillo, Yuching Yang, Xinyuan Zhang, Kimberly Bergman, Nina Isoherranen, Shiew-Mei Huang, Million A. Tegenge, Colleen Kuemmel, Stephen D. Hall, Kunal Naik, Ping Zhao, Jessica Benjamin, Lauren Milligan, Fang Wu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1271-1275 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1271-1275 (2021)
Autor:
Xiaomei Chen, Ramana S. Uppoor, Hao Zhu, Mehul Mehta, Yaning Wang, Mariam A. Ahmed, Qi Liu, Colleen Kuemmel
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 12, Iss 6, Pp 564-572 (2019)
Clinical and Translational Science, Vol 12, Iss 6, Pp 564-572 (2019)
In this paper, a special case for bioequivalence evaluation of oral formulations is discussed. Drug formulations with different forms of active moieties (e.g., free base and salt) may yield different dissolution characteristics and, thus, differ in a
Autor:
Jeffry Florian, Yaning Wang, Tina M. Morrison, Yuching Yang, Issam Zineh, Million A. Tegenge, Colleen Kuemmel, Shiew-Mei Huang, Xinyuan Zhang, Hao Zhu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 21-28 (2020)
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 1, Pp 21-28 (2020)
The use of computational models in drug development has grown during the past decade. These model-informed drug development (MIDD) approaches can inform a variety of drug development and regulatory decisions. When used for regulatory decision making,
Publikováno v:
Biochemistry. 51:4117-4125
As part of the visual cycle, the retinal chromophore in both rod and cone visual pigments undergoes reversible Schiff base hydrolysis and dissociation following photobleaching. We characterized light-activated release of retinal from a short-waveleng
Publikováno v:
Journal of Molecular Recognition. 18:150-157
Based on a study involving structural comparisons of proteins sharing 25% or less sequence identity, three rounds of Psi-BLAST appear capable of identifying remote evolutionary homologs with greater than 95% confidence provided that more than 50% of
Publikováno v:
Biochemistry. 52(30)
Visual pigments have a conserved phenylalanine in transmembrane helix 5 located near the β-ionone ring of the retinal chromophore. Site-directed mutants of this residue (F207) in a short-wavelength sensitive visual pigment (VCOP) were studied using
Autor:
Christine Insinna, Lauren L. Daniele, Sergei Nikonov, DeLaine D. Larsen, Jason A. Davis, Jinhua Wang, Colleen Kuemmel, Barry E. Knox, Edward N. Pugh
In absence of their natural ligand, 11-cis-retinal, cone opsin G-protein-coupled receptors fail to traffic normally, a condition associated with photoreceptor degeneration and blindness. We created a mouse with a point mutation (F81Y) in cone S-opsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d791b14f6dd23943b1755cbe31043d1
https://europepmc.org/articles/PMC3381355/
https://europepmc.org/articles/PMC3381355/