Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Colleen Gritzen"'
Autor:
Chi Ching Mak, Xianchang Gong, Elena Dneprovskaia, Andrew McPherson, Ved P. Pathak, J. Hood, Binqi Zeng, Boris Klebansky, Richard M. Fine, W. Liao, Wolfgang Wrasidlo, Glenn Noronha, Joel Renick, Ningning Zhao, Y. Zhou, Kathy Barrett, Colleen Gritzen, Moorthy S. S. Palanki, Xinshan Kang, Ge Li, Ute Splittgerber, Richard M. Soll, Daniel L. Lohse, Jianguo Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5546-5550
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as
Autor:
M. Reza Ghadiri, Edelmira Cabezas, Ellen Chi, Juan R. Granja, Dana A. Weinberger, Jorge Sanchez-Quesada, Véronique Dartois, Thomas R. Parr, Colleen Gritzen, Chad Dubbelde, Carrie Dunn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:3302-3310
Cyclic peptides with an even number of alternating d , l -α-amino acid residues are known to self-assemble into organic nanotubes. Such peptides previously have been shown to be stable upon protease treatment, membrane active, and bactericidal and t
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta
Autor:
Chi Ching Mak, Richard E. Fine, Andrew McPherson, John Hood, Daniel L. Lohse, Moorthy S. S. Palanki, Xinshan Kang, Colleen Gritzen, Boris Klebansky, Ved P. Pathak, Joel Renick, Richard Soll, Jianguo Cao, Binqi Zeng, Hong Zhu, Glenn Noronha
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
We describe the design, synthesis and structure-activity relationship studies in optimizing a series of benzotriazine compounds as potent inhibitors of both Abl and Abl-T315I enzymes. The design includes targeting of an acid functional residue on the
Autor:
John Doukas, Xianchang Gong, Andrew McPherson, Suhan Tang, Glenn Noronha, Tessa Brodhag, Daniel L. Lohse, Antonio Boccia, Moorthy S. S. Palanki, Ehab Y. Hanna, Hong Gu, Kathy Barrett, Colleen Gritzen, Shiyin Yee, Hong Zhu, Ningning Zhao, Chi Ching Mak, Elena Dneprovskaia, Ute Splittgerber, Chun P. Chow, Ge Li, Richard E. Fine, Jianguo Cao, Feng Shi, Richard Soll, Xinshan Kang, Steven Hu, Silva Stoughton, Jann Key, Ved P. Pathak, Binqi Zeng, Ahmed A Kousba, John Hood, Boris Klebansky, Joel Renick
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(3)
We describe the identification of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine (3), a potent, orally active Src inhibitor with desirable PK properties, demonstrated activity in human tumor cell l
Autor:
Moorthy S. S. Palanki, Jianguo Cao, Chun P. Chow, Luis Dellamary, John Doukas, Colleen Gritzen, John D. Hood, Steven Hu, Ahmed Kousba, Dan Lohse, Chi Ching Mak, Michael Martin, Andrew McPherson, Ved P. Pathak, Joel Renick, Richard Soll, Shiyin Yee, Binqi Zeng, Hong Zhu, Glenn Noronha
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1546-1559, 14p