Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Colleen G. Julian"'
Autor:
James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner, John B. West, Jiao Zhang, John Y. Shyy, Ainash Childebayeva, José Pablo Vázquez-Medina, Luu V. Pham, Omar A. Mesarwi, James E. Hall, Zachary A. Cheviron, Jeremy Sieker, Arlin B. Blood, Jason X. Yuan, Graham R. Scott, Brinda K. Rana, Paul J. Ponganis, Atul Malhotra, Frank L. Powell, Tatum S. Simonson
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypo
Externí odkaz:
https://doaj.org/article/ad6281793d794d10a1e325e2249296a9
Autor:
Litzi Lazo-Vega, Lilian Toledo-Jaldin, Abraham Badner, José Luis Barriga-Vera, Melany Castro-Monrroy, Anna G. Euser, Alison Larrea-Alvarado, Ian Lawrence, Carola Mérida, Rodrigo Mizutani, Yuri Pérez, Sebastian Rocabado, Manfredo Vargas, Vikram Vasan, Colleen G. Julian, Lorna G. Moore
Publikováno v:
The Lancet Regional Health. Americas, Vol 9, Iss , Pp 100194- (2022)
Summary: Background: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal death in low- to middle-income countries (LMIC). The American College of Obstetricians and Gynecologists (ACOG) updated diagnostic guidelines to align sign
Externí odkaz:
https://doaj.org/article/1b63b20b97ad4e558671a27bc9681c44
Autor:
Amanda K. Jones, Paul J. Rozance, Laura D. Brown, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Sean W. Limesand, Stephanie R. Wesolowski
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract Gestational hypoxemia is often associated with reduced birth weight, yet how hypoxemia controls uteroplacental nutrient metabolism and supply to the fetus is unclear. This study tested the effects of maternal hypoxemia (HOX) between 0.8 and
Externí odkaz:
https://doaj.org/article/6d39b3d4d081446c8544893989d2a34f
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding
Externí odkaz:
https://doaj.org/article/34090f45daff4f7fb6b8ca855fba9ea2
Autor:
Colleen G. Julian
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
In recent years, high-throughput genomic technologies and computational advancements have invigorated efforts to identify the molecular mechanisms regulating human adaptation to high altitude. Although exceptional progress regarding the identificatio
Externí odkaz:
https://doaj.org/article/2313acea8b324ab6ab99e4ffa7ea152c
Autor:
Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter E
Externí odkaz:
https://doaj.org/article/ab90ef4532bf424aa26dc070a2adc9be
Autor:
Kaiqi Sun, Yujin Zhang, Angelo D’Alessandro, Travis Nemkov, Anren Song, Hongyu Wu, Hong Liu, Morayo Adebiyi, Aji Huang, Yuan E. Wen, Mikhail V. Bogdanov, Alejandro Vila, John O’Brien, Rodney E. Kellems, William Dowhan, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Martin Safo, Kirk C. Hansen, Robert C. Roach, Yang Xia
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in th
Externí odkaz:
https://doaj.org/article/39c2f9d37bab46039537980e86d2c562
Autor:
Colleen G. Julian, Lorna G. Moore
Publikováno v:
Genes, Vol 10, Iss 2, p 150 (2019)
Whether Andean populations are genetically adapted to high altitudes has long been of interest. Initial studies focused on physiological changes in the O2 transport system that occur with acclimatization in newcomers and their comparison with those o
Externí odkaz:
https://doaj.org/article/2e8f490329104f3991a35de8d9831ef0
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(5)
In healthy near-term women, blood flow to the uteroplacental circulation is estimated as 841 mL/min, which is greater than in other mammalian species. We argue that as uterine venous Po2 sets the upper limit for O2 diffusion to the fetus, high uterin
Autor:
Hannah M. Kyllo, Dong Wang, Ramón A. Lorca, Colleen G. Julian, Lorna G. Moore, Randall B. Wilkening, Paul J. Rozance, Laura D. Brown, Stephanie R. Wesolowski
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Glucose, lactate, and amino acids are major fetal nutrients. During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained yet fetal glucose and amino acid sup