Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Colleen E. Keohane"'
Autor:
Xiao-wen Huang, Wen Pan, Mei-zhen Zhong, Yashpal Singh Chhonker, Andrew D. Steele, Colleen E. Keohane, Biswajit Mishra, Lewis Oscar Felix Raj Lucas, Daryl J. Murry, Frederick M. Ausubel, William M. Wuest, Chang-xing Li, Eleftherios Mylonakis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Acne vulgaris is a complex skin disease involving infection by Cutibacterium acnes , inflammation, and hyperkeratinization. We evaluated the activity of the retinoid 6-[3-(adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) and 16 other
Autor:
Savannah J. Post, Colleen E. Keohane, Lauren M. Rossiter, Anna R. Kaplan, Jittasak Khowsathit, Katie Matuska, John Karanicolas, William M. Wuest
Publikováno v:
ACS Infectious Diseases. 8:1376-1376
Autor:
Lauren M. Rossiter, William M. Wuest, John Karanicolas, Colleen E. Keohane, Savannah J Post, Katie Matuska, Anna R. Kaplan, Jittasak Khowsathit
Publikováno v:
ACS Infect Dis
Promysalin is a small-molecule natural product that specifically inhibits growth of the Gram-negative pathogen Pseudomonas aeruginosa (PA). This activity holds promise in the treatment of multidrug resistant infections found in immunocompromised pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976ec8bbd170c3bc341b2446962b11b1
https://europepmc.org/articles/PMC7293565/
https://europepmc.org/articles/PMC7293565/
Autor:
William M. Wuest, Paul Stodghill, Stephan A. Sieber, Colleen E. Keohane, Andrew D. Steele, Christian Fetzer, Melanie J. Filiatrault, Krista M Giglio
Publikováno v:
ACS Infectious Diseases. 4:1179-1187
Promysalin, a secondary metabolite produced by P. putida RW10S1, is a narrow-spectrum antibiotic that targets P. aeruginosa over other Pseudomonas spp. P. putida KT2440, a nonproducing strain, displays increased swarming motility and decreased pyover
Publikováno v:
Synlett. 26:2739-2744
The threat of antibiotic-resistant bacteria is an ongoing battle that continues to confound scientists and doctors alike. Reinvestigation of past methods has led to the interrogation of natural microbiomes with the goal of identifying the survival me
Autor:
Daria Van Tyne, Jittasak Khowsathit, Michael S. Gilmore, John Karanicolas, Andrew D. Steele, Lucile Moynié, William M. Wuest, Stephan A. Sieber, Christian Fetzer, Colleen E. Keohane
Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum antibacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdafd34b3bd346b2ee581b26037417f5
https://europepmc.org/articles/PMC5869686/
https://europepmc.org/articles/PMC5869686/
Publikováno v:
Journal of the American Chemical Society. 137:7314-7317
Compounds that specifically target pathogenic bacteria are greatly needed, and identifying the method by which they act would provide new avenues of treatment. Herein we report the concise, high-yielding total synthesis (eight steps, 35% yield) of pr
Autor:
Kiho Lee, Andrew D. Steele, Petia M. Vlahovska, Beth Burgwyn Fuchs, Michael S. Gilmore, Nico Fricke, William M. Wuest, Annie L. Conery, Wen Pan, Wooseong Kim, Colleen E. Keohane, Huajian Gao, Wenpeng Zhu, Steven S. Shen, Eleftherios Mylonakis, Daria Van Tyne, Rajmohan Rajamuthiah, Frederick M. Ausubel, Gabriel L. Hendricks
Publikováno v:
Nature. 556(7699)
A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant ‘persister’ subpopulations that exhibit high levels of tolerance t
Autor:
Sean E. Rossiter, William M. Wuest, Kyle W. Knouse, Andrew D. Steele, Sierra J. Williams, Colleen E. Keohane
Publikováno v:
Journal of the American Chemical Society. 138(18)
Promysalin is a species-specific Pseudomonad metabolite with unique bioactivity. To better understand the mode of action of this natural product, we synthesized 16 analogs utilizing diverted total synthesis (DTS). Our analog studies revealed that the
Publikováno v:
ChemInform. 46
Compounds that specifically target pathogenic bacteria are greatly needed, and identifying the method by which they act would provide new avenues of treatment. Herein we report the concise, high-yielding total synthesis (eight steps, 35% yield) of pr