Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Colleen A. Vanderbilt"'
Autor:
Craig J. Gibson, Kathleen McGlynn, Michael C. Lawrence, Wei Chen, Colleen A. Vanderbilt, Tara Beers Gibson, Marlon F. Levy, Bashoo Naziruddin, Don Arnette, Melanie H. Cobb, Barbara E. Ehrlich, Julie Collins
Publikováno v:
Diabetes. 55:1066-1073
Glucose sensing is essential for the ability of pancreatic beta-cells to produce insulin in sufficient quantities to maintain blood glucose within the normal range. Stress causes the release of adrenergic hormones that increase circulating glucose by
Autor:
Kathleen McGlynn, Tara Beers Gibson, Shih Khoo, Michael C. Lawrence, Bridgette January, Melanie H. Cobb, Don Arnette, Colleen A. Vanderbilt
Publikováno v:
Journal of Biological Chemistry. 278:32517-32525
We showed previously that ERK1/2 were activated by glucose and amino acids in pancreatic beta cells. Here we examine and compare signaling events that are necessary for ERK1/2 activation by glucose and other stimuli in beta cells. We find that agents
Autor:
Paul C. Sternweis, Colleen A. Vanderbilt, Melanie H. Cobb, Lori B. Christerson, Clark D. Wells, Angelique W. Whitehurst, Ewen D. Gallagher, Roxana Kazempour
Publikováno v:
Journal of Cellular Physiology. 192:200-208
Mammalian MAP/ERK kinase kinase 1 (MEKK1) was identified as a mammalian homolog of Ste11p of the yeast pheromone-induced mating pathway. Like Ste11p, MEKK1 is a MAP3 kinase linked to at least two MAP kinase cascades and regulatory events that require
Publikováno v:
Cell Motility and the Cytoskeleton. 43:186-198
Mitogen-activated protein (MAP) kinases orchestrate the effects of many extracellular stimuli on cells. The serine/threonine protein kinase MEKK1 is an upstream activator of the MAP kinases c-Jun N-terminal kinase/stress-activated protein kinase (JNK
Autor:
Lori B. Christerson, Melanie H. Cobb, Colleen A. Vanderbilt, Shuichan Xu, Jessie M. English, David J. Robbins
Publikováno v:
Proceedings of the National Academy of Sciences. 93:5291-5295
The coding sequence of rat MEK kinase 1 (MEKK1) has been determined from multiple, independent cDNA clones. The cDNA is full-length based on the presence of stop codons in all three reading frames of the 5' untranslated region. Probes from the 5' and
Publikováno v:
Journal of Biological Chemistry. 270:28897-28902
The prototype mitogen-activated protein (MAP) kinase module is a three-kinase cascade consisting of the MAP kinase, extracellular signal-regulated protein kinase (ERK) 1 or ERK2, the MAP/ERK kinase (MEK) MEK1 or MEK2, and the MEK kinase, Raf-1 or B-R
Autor:
Douglas Ebert, Mangeng Cheng, Alphonsus Dang, Clark Garcia, David J. Robbins, Erzhen Zhen, Shuichan Xu, Colleen A. Vanderbilt, Melanie H. Cobb
Publikováno v:
Journal of the American Society of Nephrology. 4:1104-1110
The extracellular signal-regulated kinases ERK1 and ERK2 are 43- and 41-kd enzymes activated by many extracellular cues. They lie within a protein kinase cascade that is used to achieve many cellular responses. In addition to the wide variety of regu
Autor:
Hajime Owaki, Melanie H. Cobb, Douglas Ebert, Erzhen Zhen, Thomas D. Geppert, Colleen A. Vanderbilt, David J. Robbins
Publikováno v:
Journal of Biological Chemistry. 268:5097-5106
Extracellular signal-regulated protein kinases (ERK) 1 and 2 and mutants of each were expressed in bacteria with a hexahistidine tag and purified using nickel-chelate chromatography. Basal activity of wild type ERK2 was approximately 2 nmol/min/mg. S
Autor:
Colleen A. Vanderbilt, Erzhen Zhen, Mangeng Cheng, Melanie H. Cobb, David J. Robbins, Larry A. Feig
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6924-6928
The small GTP-binding protein Ras appears to be required for transformation and differentiation induced by tyrosine kinases. The Ras requirement may be limited to a few tyrosine kinase-regulated signaling pathways or may be universal for all tyrosine
Autor:
Clark Garcia, Douglas Ebert, Alphonsus Dang, Erzhen Zhen, David J. Robbins, Melanie H. Cobb, Colleen A. Vanderbilt, Mangeng Cheng
Publikováno v:
The Cell Cycle ISBN: 9781461360278
Extracellular signal-regulated kinases (ERKs)1–4 are protein kinases participating in numerous signal transduction pathways. The two best studied of these, ERK1 and ERK2, are known as MAP kinases and were first identified as 43 and 41 kDa, hormonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4bdf320e8aeeb00ccc0a15b48895a8
https://doi.org/10.1007/978-1-4615-2421-2_7
https://doi.org/10.1007/978-1-4615-2421-2_7