Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury

Autor: Christopher L. Nauser, Mark C. Howard, Giorgia Fanelli, Conrad A. Farrar, Steven Sacks

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and priming the adaptive immune response. Over the last 40 years our understanding of the complement

Externí odkaz: https://doaj.org/article/f9b4b1b245624313a54d81fcafcf7cc9

Role of collectin-11 in innate defence against uropathogenicEscherichia coliinfection

Autor: Fengqi Hu, Hai Yuan, Zhao Gao, Xiaohan Lu

Publikováno v: Innate Immunity

Classical collectins (surfactant protein A and D) play a significant role in innate immunity and host defence in uropathogenic Escherichia coli (UPEC)-induced urinary tract infection (UTI). However, the functions of collectin-11 (CL-11) with respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36abf5d725d06881ff7e33a1fd0cab2
https://doi.org/10.1177/1753425920974766

l-Fucose prevention of renal ischaemia/reperfusion injury in Mice

Autor: Steven H. Sacks, Conrad A. Farrar, Russell Wallis, Mark Christopher Howard, Christopher L Nauser

Publikováno v: Howard, M C, Nauser, C L, Farrar, C A, Wallis, R & Sacks, S H 2020, ' l-Fucose prevention of renal ischaemia/reperfusion injury in Mice ', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 34, no. 1, pp. 822-834 . https://doi.org/10.1096/fj.201901582R
The FASEB Journal

In a recent study, we identified a fucosylated damage‐associated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition by collectin‐11 (CL‐11 or collectin kidney 1 (CL‐K1)), initiates complement activation and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675d863bb5a8e8c7e687567f3a07c042
https://kclpure.kcl.ac.uk/en/publications/aa739049-ab34-4b10-8944-fbfe78a38d1d

Importance of glycosylation in the interaction of Tamm-Horsfall protein with collectin-11 and acute kidney injury

Autor: Yuqing Chen, Lufeng Bai, Fengxue Zhu, Wantao Ying, Kunjing Gong, Min Xia, Yaqin Wang

Publikováno v: Journal of Cellular and Molecular Medicine

Both Tamm‐Horsfall protein (THP) and collectin‐11 (CL‐11) are important molecules in acute kidney injury (AKI). In this study, we measured the change of glycosylation of THP in patients with AKI after surgery, using MALDI‐TOF MS and lectin ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cddee40e8f42538b509c5cad386f819
https://pubmed.ncbi.nlm.nih.gov/32045104

Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury

Autor: Giorgia Fanelli, Mark Christopher Howard, Conrad A. Farrar, Steven H. Sacks, Christopher L Nauser

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and priming the adaptive immune response. Over the last 40 years our understanding of the complement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622dabe6b7930af472e12909bc5c79a3
https://pubmed.ncbi.nlm.nih.gov/30237800