Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Collapsin response mediator protein family"'
Autor:
Jifeng Zhang, Guoqing Guo, Jiaqi Zhang, Keen Chen, Jiaming Wu, Li Chen, Longfei Cheng, Jiong Li
Publikováno v:
Molecular Neurobiology. 59:762-777
AMPA receptor mediate most fast excitatory synaptic transmission and play a key role in synaptic plasticity in the central nervous system (CNS) by trafficking and targeting of its subunits to individual postsynaptic membrane. Collapsing response medi
Autor:
Qin Wang, Xiaohui Zhang, Xiang Li, Jiaying Xiao, Xiang Gu, Yuan Zhang, Zhiheng Xu, Li Yao, Meizhen Meng, Ziwei Shang
Publikováno v:
Science Bulletin. 66:2225-2237
Brain-specific loss of a microtubule-binding protein collapsin response mediator protein-2 (CRMP2) in the mouse recapitulates many schizophrenia-like behaviors of human patients, possibly resulting from associated developmental deficits in neuronal d
Autor:
Fumiko Takenoya, Ai Kimura, Junko Shibato, Michio Yamashita, Seiji Shioda, Takahiro Hirabayashi, Ichiro Takasaki, Randeep Rakwal
Publikováno v:
Neural Plasticity
Neural Plasticity, Vol 2021 (2021)
Neural Plasticity, Vol 2021 (2021)
The present research investigates the molecular mechanism of neurite outgrowth (protrusion elongation) under pituitary adenylate cyclase-activating polypeptide (PACAP) 38 treatments using a rat adrenal-derived pheochromocytoma cell line—PC12. This
Autor:
Toshio Ohshima, Jun Nagai, Tianhong Cai, Takafumi Inoue, Yuki Yamazaki, Maho Moizumi, Papachan Kolattukudy, Yoshiki Hatashita, Yoshio Goshima
Publikováno v:
Cerebral Cortex. 32:520-527
The mammalian cerebral cortex is characterized by a 6-layer structure, and proper neuronal migration is critical for its formation. Cyclin-dependent kinase 5 (Cdk5) has been shown to be a critical kinase for neuronal migration. Several Cdk5 substrate
Autor:
Mary Chol, Ivana Poparic, Sarah Guthrie, Isaac H. Bianco, Renata Feret, Ragnheiður Guðjónsdóttir, Madeline Louise Reilly, Marco Chiapello, Michael J. Deery, Luis Carretero-Rodriguez
Publikováno v:
J Neurosci
A precise sequence of axon guidance events is required for the development of the ocular motor system. Three cranial nerves grow towards, and connect with, six extraocular muscles in a stereotyped pattern, in order to control eye movements. The signa
Autor:
Jichun Zhang, Junliang Li, Zheng Zhang, Li Yan, Zi-Jian Wang, Fei Xiao, Jun-Ping Pan, Zhidong Zhang, Qin Gao, Yu Li, Zhipeng Ling
Publikováno v:
Applied Microbiology and Biotechnology. 105:4649-4662
Alzheimer's disease (AD) is a type of progressive neurodegenerative disease, and amyloid β-protein 42 (Aβ42) serves an important role in the pathological process of development of AD. Paired immunoglobulin-like receptor B (PirB) is a functional rec
Autor:
Zhaoxia Liao, Junhua Li, Yujuan Li, Zeqi Huang, Yanhui Liu, Jing Zhang, Hui Li, Liping Miao, Ying Xu
Publikováno v:
Toxicology Letters. 341:68-79
Background General anesthetics such as sevoflurane interfere with dendritic development and synaptogenesis, resulting in cognitive impairment. The collapsin response mediator protein2 (CRMP2) plays important roles in dendritic development and synapti
Publikováno v:
Cancer Research. 81:1321-1331
Deubiquitinating enzymes are increasingly recognized to play important roles in cancer, with many acting as oncogenes or tumor suppressors. In this study, we employed a bioinformatics approach to screen for enzymes from this family involved in cancer
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Molecular Brain
Molecular Brain
Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2). When not SUM
Autor:
Yoshio Goshima, Ayaka Sugeno, Kiyofumi Takahashi, Miki Yamazaki, Masahito Hosokawa, Koji Arikawa, Wenhui Piao, Daisuke Tominaga, Hiroko Matsunaga, Haruko Takeyama, Toshio Ohshima
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 16, Iss 7, Pp 1258-1265 (2021)
Neural Regeneration Research, Vol 16, Iss 7, Pp 1258-1265 (2021)
Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2 (CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury (SCI). We