Výsledky vyhledávání - "Colin W. Stets"

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

Autor: Achal Awasthi, John L. Hays, Bryce Demoret, Nicholas Grosenbacher, Colin W. Stets, James L. Chen, Reena Shakya, Nathan D. Seligson

Publikováno v: Oncotarget

Dedifferentiated liposarcoma (DDLPS) is a highly morbid mesenchymal tumor characterized and driven by genomic amplification of the MDM2 gene. Direct inhibition of MDM2 has shown promise pre-clinically, but has yet to be validated in clinical trials.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9a421836329f8ff75ee2a35e0b0e63
https://doi.org/10.18632/oncotarget.27144

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Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma

Autor: Colin W. Stets, Cynthia Timmers, John L. Hays, Achal Awasthi, Nathan D. Seligson, James L. Chen, Kate Lynn J. Bill, Paul E. Wakely, Guy Brock, Megan C. Duggan, Reena Shakya, Manojkumar Bupathi, Raphael E. Pollock, Bryce Demoret, Sherri Z. Millis

Publikováno v: The Oncologist. 24:989-996

Background Dedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 (MDM2) is used as a diagnostic biomarker; however, no established biomarke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::210047f97809670b8adaa2d8b86794ee
https://doi.org/10.1634/theoncologist.2019-0047

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Identifying targetable markers of resistance to dual TORC1/2 inhibition in endometrial cancer cell lines

Autor: Katie McGreal, Sarah Crafton, Jason David, Colin W. Stets, Nicholas Grosenbacher, James Lin Chen, John L. Hays

Publikováno v: Journal of Clinical Oncology. 40:e17633-e17633

e17633 Background: For patients with endometrial cancer, the PI3K/AKT/mTOR pathway is an attractive target due to dysregulation of the pathway secondary to commonly found genetic alterations. Previous trials of mTOR inhibitors in endometrial cancer h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c96f05391bb3659839190a6b6417ed7c
https://doi.org/10.1200/jco.2022.40.16_suppl.e17633

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BRCA1/2 Functional Loss Defines a Targetable Subset in Leiomyosarcoma

Autor: Sherri Z. Millis, Amanda E. Toland, John L. Hays, Christian F. Meyer, James L. Chen, Nathan D. Seligson, Esko A. Kautto, Colin W. Stets, Edward N. Passen

Publikováno v: The Oncologist. 24:973-979

Background Soft-tissue sarcomas (STS) describe a heterogeneous group of mesenchymal tumors with limited treatment options. Targeted therapies exist for BRCA1/2 gene alterations, but their prevalence and role have not been fully described in STS. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2315056d9d737b7b7d9741f3dcc4e5
https://doi.org/10.1634/theoncologist.2018-0448

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MDM2-Dependent Rewiring of Metabolomic and Lipidomic Profiles in Dedifferentiated Liposarcoma Models

Autor: Philip B. Smith, Anitha Vijay, Andrew D. Patterson, John L. Hays, Kate Lynn J. Bill, Mindy Hoang, Bryce Demoret, Colin W. Stets, Ewy Mathé, Andrew Patt, James L. Chen

Publikováno v: Cancers
Cancers, Vol 12, Iss 2157, p 2157 (2020)
Volume 12
Issue 8

Dedifferentiated liposarcoma (DDLPS) is an aggressive mesenchymal cancer marked by amplification of MDM2, an inhibitor of the tumor suppressor TP53. DDLPS patients with higher MDM2 amplification have lower chemotherapy sensitivity and worse outcome t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543f5fad50c9ab70a98724cff8ac2ebb
https://pubmed.ncbi.nlm.nih.gov/32759684

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Degree of

Autor: Kate Lynn J, Bill, Nathan D, Seligson, John L, Hays, Achal, Awasthi, Bryce, Demoret, Colin W, Stets, Megan C, Duggan, Manojkumar, Bupathi, Guy N, Brock, Sherri Z, Millis, Reena, Shakya, Cynthia D, Timmers, Paul E, Wakely, Raphael E, Pollock, James L, Chen

Publikováno v: The oncologist. 24(7)

BACKGROUND. Dedifferentiated liposarcomas (DDLPS) are mesenchymal tumors associated with universally poor response to treatment. Genomic amplification of murine double minute 2 (MDM2) is used as a diagnostic biomarker; however, no established biomark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::379c328421b2012e16a14adc9728532a
https://pubmed.ncbi.nlm.nih.gov/31019022

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Multiscale omic assessment of EWSR1-NFATc2 fusion positive sarcomas to identify conserved fusion breakpoint and activation of the mTOR pathway

Autor: Colin W. Stets, Nathan D. Seligson, Sherri Z. Millis, Howard M. Katzenstein, Richard D Maradiaga, John L. Hays, James L. Chen

Publikováno v: Journal of Clinical Oncology. 38:e23536-e23536

e23536 Background: EWSR1-NFATc2 ( E-N) fusion positive sarcomas are rare cancers historically categorized as Ewing sarcomas. Emerging evidence suggests unique molecular characteristics and chemotherapy sensitivities in these cancers. Here we present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb719147e07c59ec0c3ccce535bf927d
https://doi.org/10.1200/jco.2020.38.15_suppl.e23536

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CEACAM6 as a candidate biomarker for pelareorep sensitivity in pancreatic adenocarcinoma (PDAC)

Autor: Mindy Hoang, James L. Chen, Tanios Bekaii-Saab, Colin W. Stets, John L. Hays, Jason J. David, Cynthia Timmers, Wendy L. Frankel, Anne M. Noonan, Jacob S. Yount, Ying Huang

Publikováno v: Journal of Clinical Oncology. 38:746-746

746 Background: Pelareorep is a proprietary formulation of live, replication-competent, naturally occurring Reovirus Type 3 Dearing strain. A randomized phase II trial of pelareorep in combination with carboplatin and paclitaxel in first-line treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae218712e41e64111367c25e19ba317e
https://doi.org/10.1200/jco.2020.38.4_suppl.746

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Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition

Autor: Jason J. David, Douglas M Spaeth-Cook, John L. Hays, Reena Shakya, James L. Chen, David Cohen, Bryce Demoret, Colin W. Stets, Robin Belton, Nicholas Grosenbacher, Mark G. Burch

Publikováno v: Oncotarget

// Douglas Spaeth-Cook 1 , Mark Burch 2 , Robin Belton 1 , Bryce Demoret 1 , Nicholas Grosenbacher 1 , Jason David 2 , Colin Stets 1 , David Cohen 4 , Reena Shakya 5 , John L. Hays 3, 6, * and James L. Chen 1, 3, * 1 Department of Biomedical Informat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f81bd059a001a45e9278feb892e6c16
https://pubmed.ncbi.nlm.nih.gov/30479697

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Social overcrowding as a chronic stress model that increases adiposity in mice

Autor: Eugene Y. Choi, Meng Sun, En-Ju D. Lin, Colin W. Stets, Daniel Magee, Matthew J. During

Publikováno v: Psychoneuroendocrinology. 51:318-330

Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2bf28a5872844d953ef127ec805529
https://doi.org/10.1016/j.psyneuen.2014.10.007

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