Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Colin W. Levy"'
Autor:
Shaowei Zhang, Laura N. Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O. Johannissen, Lingyun Zhu, Matthew J. Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W. Levy, David Leys, Derren J. Heyes, Nigel S. Scrutton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Photoreceptor proteins utilise chromophores to sense light and trigger a biological response. The discovery that adenosylcobalamin (or coenzyme B12) can act as a light-sensing chromophore heralded a new field of B12-photobiology. Although mi
Externí odkaz:
https://doaj.org/article/a0f44c530eda465fa74001ba20e7cc49
Autor:
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J. Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O. Johannissen, Colin W. Levy, Laura N. Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schirò, Martin Weik, Nigel S. Scrutton, David Leys
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract CarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis. How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear. Here, a seri
Externí odkaz:
https://doaj.org/article/001606f7b0874be9a4255441eb03bd98
Autor:
Dr. Safaa M. Kishk, Dr. Kirsty J. McLean, Dr. Sakshi Sood, Darren Smith, Jack W.D. Evans, Prof. Mohamed A. Helal, Prof. Mohamed S. Gomaa, Prof. Ismail Salama, Prof. Samia M. Mostafa, Dr. Luiz Pedro S. de Carvalho, Colin W. Levy, Prof. Andrew W. Munro, Dr. Claire Simons
Publikováno v:
ChemistryOpen, Vol 8, Iss 7, Pp 995-1011 (2019)
Abstract The emergence of untreatable drug‐resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450
Externí odkaz:
https://doaj.org/article/3aae741715394bd2a5f6041ac6a202cf
Autor:
Allison J. Bancroft, Colin W. Levy, Thomas A. Jowitt, Kelly S. Hayes, Seona Thompson, Edward A. Mckenzie, Matthew D. Ball, Eamon Dubaissi, Aidan P. France, Bruno Bellina, Catherine Sharpe, Aleksandr Mironov, Sheila L. Brown, Peter C. Cook, Andrew S. MacDonald, David J. Thornton, Richard K. Grencis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm
Externí odkaz:
https://doaj.org/article/e790a9921fd644c2949b6cd1e5687605
Autor:
Mohd Zulkifli Salleh, Vijaykumar Karuppiah, Matthew Snee, Angela Thistlethwaite, Colin W. Levy, David Knight, Jeremy P. Derrick
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Natural competence is the term used to describe the uptake of “naked” extracellular DNA by bacteria; it plays a significant role in horizontal genetic exchange. It is associated with type IV pili, and specialized competence pili mediate
Externí odkaz:
https://doaj.org/article/659fe2932b8743b2a327295f116a2110
Autor:
Mona M. Katariya, Matthew Snee, Richard B. Tunnicliffe, Madeline E. Kavanagh, Helena I. M. Boshoff, Cecilia N. Amadi, Colin W. Levy, Andrew W. Munro, Chris Abell, David Leys, Anthony G. Coyne, Kirsty J. McLean
Funder: Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Id: http://dx.doi.org/10.13039/100006492
Funder: Cambridge Trust; Id: http://dx.doi.org/10.13039/501100003343
Mycobacterium tuberculosis (Mtb) w
Funder: Cambridge Trust; Id: http://dx.doi.org/10.13039/501100003343
Mycobacterium tuberculosis (Mtb) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139d9139a1ac4d5afba661d0322e8c46
https://www.repository.cam.ac.uk/handle/1810/347549
https://www.repository.cam.ac.uk/handle/1810/347549
Autor:
Joshua N. Whitehead, Nicole G. H. Leferink, Gajendar Komati Reddy, Colin W. Levy, Sam Hay, Eriko Takano, Nigel S. Scrutton
Publikováno v:
Whitehead, J N, Leferink, N G H, Komati Reddy, G, Levy, C W, Hay, S, Takano, E & Scrutton, N S 2022, ' How a 10-epi-cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity ', ACS Catalysis, vol. 12, no. 19, pp. 12123–12131 . https://doi.org/10.1021/acscatal.2c03155
Terpenes are the largest class of natural products, and are attractive targets in the fuel, fragrance, pharmaceutical, and flavour industries. Harvesting terpenes from natural sources is environmentally intensive, and often gives low yields and purit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7125ef6357d36eac70c0d9d059cca3
https://research.manchester.ac.uk/en/publications/5b51e414-80a0-48c6-81d3-146073f9ff96
https://research.manchester.ac.uk/en/publications/5b51e414-80a0-48c6-81d3-146073f9ff96
Autor:
Ravindra Pal Singh, Jayashree Niharika, Raksha Thakur, Ben A. Wagstaff, Gulshan Kumar, Rikuya Kurata, Dhaval Patel, Colin W. Levy, Takatsugu Miyazaki, Robert A. Field
Publikováno v:
Journal of Biological Chemistry. :104806
Autor:
Joshua N, Whitehead, Nicole G H, Leferink, Gajendar, Komati Reddy, Colin W, Levy, Sam, Hay, Eriko, Takano, Nigel S, Scrutton
Publikováno v:
ACS catalysis. 12(19)
Terpenes are the largest class of natural products and are attractive targets in the fuel, fragrance, pharmaceutical, and flavor industries. Harvesting terpenes from natural sources is environmentally intensive and often gives low yields and purities
Autor:
Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green
Publikováno v:
Trimble, J, Crawshaw, R, Hardy, F, Levy, C, Brown, M J B, Fuerst, D E, Heyes, D, Obexer, R & Green, A 2022, ' A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions ', Nature., vol. 611, no. 7937 . https://doi.org/10.1038/s41586-022-05335-3
The ability to programme new modes of catalysis into proteins would allow the development of enzyme families with functions beyond those found in nature. To this end, genetic code expansion methodology holds particular promise, as it allows the site-