Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Colin T Shearn"'
Autor:
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky, Ronald J Sokol
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290385 (2023)
BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile
Externí odkaz:
https://doaj.org/article/5602d9fb629c4595ba73c8d57a6b453a
Autor:
Colin T Shearn, Aimee L Anderson, Michael W Devereux, David J Orlicky, Cole Michel, Dennis R Petersen, Colin G Miller, Sanjiv Harpavat, Edward E Schmidt, Ronald J Sokol
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276879 (2022)
Inflammatory cholestatic liver diseases, including Primary Sclerosing Cholangitis (PSC), are characterized by periportal inflammation with progression to cirrhosis. The objective of this study was to examine interactions between oxidative stress and
Externí odkaz:
https://doaj.org/article/ce15a1ec4a624b35aa47d9ec04c0050d
Autor:
Dennis R Petersen, Laura M Saba, Volkan I Sayin, Thales Papagiannakopoulos, Edward E Schmidt, Gary F Merrill, David J Orlicky, Colin T Shearn
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198139 (2018)
OBJECTIVE:In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease (NASH) is oxidative stress, which leads to the accumulation of highly reactive electrophilic α/β unsaturated aldehydes. The objective of this stu
Externí odkaz:
https://doaj.org/article/793220ba70584b0b896cee073cdfa37a
Autor:
Colin T Shearn, David J Orlicky, Rebecca L McCullough, Hua Jiang, Kenneth N Maclean, Kelly E Mercer, Bangyan L Stiles, Laura M Saba, Martin J Ronis, Dennis R Petersen
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154152 (2016)
Alcoholic liver disease is a significant contributor to global liver failure. In murine models, chronic ethanol consumption dysregulates PTEN/Akt signaling. Hepatospecific deletion of phosphatase and tensin homolog deleted on chromosome 10 (PTENLKO)
Externí odkaz:
https://doaj.org/article/26671a9f1cd94781bdbb71a1ef7e860b
Autor:
Colin T Shearn, Kelly E Mercer, David J Orlicky, Leah Hennings, Rebecca L Smathers-McCullough, Bangyan L Stiles, Martin J J Ronis, Dennis R Petersen
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96553 (2014)
Hepatospecific deletion of PTEN results in constitutive activation of Akt and increased lipogenesis. In mice, the addition of a high fat diet (HFD) downregulates lipogenesis. The aim of this study was to determine the effects of a HFD on hepatocellul
Externí odkaz:
https://doaj.org/article/68d583e19f9d478cbaab11e66f0aad96
Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.
Autor:
Rebecca L Smathers, Kristofer S Fritz, James J Galligan, Colin T Shearn, Philip Reigan, Michael J Marks, Dennis R Petersen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38459 (2012)
4-Hydroxynonenal (4-HNE) is a reactive α,β-unsaturated aldehyde produced during oxidative stress and subsequent lipid peroxidation of polyunsaturated fatty acids. The reactivity of 4-HNE towards DNA and nucleophilic amino acids has been well establ
Externí odkaz:
https://doaj.org/article/a43529552d424d638a9632372389a623
Autor:
Michael W. Devereaux, Frederick J. Suchy, Angelo D'Alessandro, Ronald J. Sokol, Swati Ghosh, Colin T. Shearn, Karim C. El Kasmi, David J. Orlicky, Aimee L. Anderson, Natarajan Balasubramaniyan
Publikováno v:
Hepatology. 75:252-265
Parenteral nutrition (PN)-associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL-1β derived from activated hepatic macrophages to suppress h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a536832e24861e64956858a3a4d78508
https://doi.org/10.1002/hep.32101
https://doi.org/10.1002/hep.32101
Autor:
David J. Orlicky, Karim C. El Kasmi, Mark A. Lovell, Swati Ghosh, Ronald J. Sokol, Aimee L. Anderson, Sarah Gehrke, Michael W. Devereaux, Julie A. Reisz, Colin T. Shearn, Angelo D'Alessandro
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Chronically administered parenteral nutrition (PN) in patients with intestinal failure carries the risk for developing PN-associated cholestasis (PNAC). We have demonstrated that farnesoid X receptor (FXR) and liver X receptor (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f891a063835002c199614ef64d3d2e
https://doi.org/10.1002/hep.32071
https://doi.org/10.1002/hep.32071
Autor:
Kayla D. Battista, Jordi M. Lanis, Cynthia Ju, Sean P. Colgan, David J. Orlicky, Erica E. Alexeev, Blair Fennimore, Colin T. Shearn, Ian M. Cartwright, Rachael Kostelecky, Rachel Y. Gao
Publikováno v:
Mucosal immunology
Primary sclerosing cholangitis (PSC) is a progressive fibrosing cholestatic liver disease that is strongly associated with inflammatory bowel disease (IBD). PSC-associated IBD (PSC-IBD) displays a unique phenotype characterized by right-side predomin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16723ab4548644761e6efded04955e34
http://europepmc.org/articles/PMC7954872
http://europepmc.org/articles/PMC7954872
Autor:
Nicholas J. Carruthers, Donald S. Backos, Mandar Deshpande, Haiyan Pang, Colin T. Shearn, Suresh S. Palaniyandi, Guodong Pan, Paul M. Stemmer
Publikováno v:
J Cell Biochem
Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive alde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcbc07960774af03f379629e3bfbb32
https://doi.org/10.1002/jcb.29814
https://doi.org/10.1002/jcb.29814