Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

Autor: Lauren Brash, MD, Gareth D. Barnes, MD, Melanie J. Brewis, MD, A. Colin Church, MD, Simon J. Gibbs, MD, Luke S.G.E. Howard, MD, Geeshath Jayasekera, MBChB, Martin K. Johnson, MD, Neil McGlinchey, MBChB, Joelle Onorato, PhD, Joanne Simpson, MD, Colin Stirrat, MD, Stephen Thomson, MBChB, Geoffrey Watson, MD, Martin R. Wilkins, MD, Carrie Xu, MS, David J. Welsh, PhD, David E. Newby, MD, Andrew J. Peacock, MD

Publikováno v: JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 176-186 (2018)

Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of syst

Externí odkaz: https://doaj.org/article/dabac17dc7ae4c07888b359d538839c4

Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation

Autor: Marc R. Dweck, Vassilios S. Vassiliou, Colin Stirrat, Simon C. Eccleshall, Tharusha Gunawardena, David E. Newby, Donnie Cameron, Ioannis Merinopoulos

Publikováno v: JACC: Cardiovascular Imaging, 14(6), 1249-1264. ELSEVIER SCIENCE INC

Cardiac magnetic resonance (CMR) is at the forefront of noninvasive methods for the assessment of myocardial anatomy, function, and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdcd7e051c7d08fd668e5363ab3c74b
https://ueaeprints.uea.ac.uk/id/eprint/75506/1/Accepted_Manuscript.pdf

Ferumoxytol-enhanced MRI in patients with prior cardiac transplantation

Autor: John R. Payne, Colin Stirrat, Sanjay K Prasad, Saeed Mirsadraee, Scott Semple, Roy S Gardner, David E. Newby, Tom MacGillivray, Marc R. Dweck, Shirjel Alam, Victor Jones, Mark C. Petrie, Calum Gray, William Wallace, Peter Henriksen

Publikováno v: Open Heart

ObjectivesUltra-small superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect cellular inflammation within tissues and may help non-invasively identify cardiac transplant rejection. Here, we aimed to determine the normal reference v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bffa31c3097577ddbc40ba43fddcd74
https://pubmed.ncbi.nlm.nih.gov/31673393

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

Autor: Lauren, Brash, Gareth D, Barnes, Melanie J, Brewis, A Colin, Church, Simon J, Gibbs, Luke S G E, Howard, Geeshath, Jayasekera, Martin K, Johnson, Neil, McGlinchey, Joelle, Onorato, Joanne, Simpson, Colin, Stirrat, Stephen, Thomson, Geoffrey, Watson, Martin R, Wilkins, Carrie, Xu, David J, Welsh, David E, Newby, Andrew J, Peacock

Publikováno v: Jacc. Basic to Translational Science

Visual Abstract
Highlights • The effects of apelin on pulmonary hemodynamics in patients with PAH are unknown. • Systemic infusion caused a significant reduction in pulmonary vascular resistance and increase in cardiac output without a chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b60e50b89d94a0024b32c792d622a9f
https://pubmed.ncbi.nlm.nih.gov/29876530

Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery:a randomised-controlled trial

Autor: Kirsteen Goodman, K Oatey, Oliver Wiedow, Shirjel Alam, Steff C Lewis, Colin Stirrat, David E. Newby, C Moore, R Pessotto, Ashma Krishan, Saeed Mirsadraee, Harkess R, Scott Semple, L Milne, Vipin Zamvar, N M Mills, Peter Henriksen, Marc R. Dweck, S Thomas

Publikováno v: Alam, S R, Lewis, S C, Zamvar, V, Pessotto, R, Dweck, M R, Krishan, A, Goodman, K, Oatey, K, Harkess, R, Milne, L, Thomas, S, Mills, N M, Moore, C, Semple, S, Wiedow, O, Stirrat, C, Mirsadraee, S, Newby, D E & Henriksen, P A 2015, ' Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery : a randomised-controlled trial ', Heart, vol. 101, no. 20 . https://doi.org/10.1136/heartjnl-2015-307745
Heart

BACKGROUND: Elafin is a potent endogenous neutrophil elastase inhibitor that protects against myocardial inflammation and injury in preclinical models of ischaemic-reperfusion injury. We investigated whether elafin could inhibit myocardial ischaemia-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8699a806e7439de7703398b8cf4998c0
https://www.pure.ed.ac.uk/ws/files/21495796/Heart_2015_Alam_heartjnl_2015_307745.pdf