Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Colin S Duckett"'
Publikováno v:
PLoS Pathogens, Vol 4, Iss 8, p e1000142 (2008)
The inhibitor of apoptosis protein (IAP) family has been implicated in immune regulation, but the mechanisms by which IAP proteins contribute to immunity are incompletely understood. We show here that X-linked IAP (XIAP) is required for innate immune
Externí odkaz:
https://doaj.org/article/48367542f33f44feb639dfef27f17f9d
Autor:
Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, Chen Liu, Cynthia Zajac, Shin-Rong Julia Wu, Yaping Sun, Hideaki Fujiwara, Hiroya Tamaki, Daniel Peltier, Mary Riwes, Israel Henig, Stuart Brabbs, Colin S. Duckett, Shaomeng Wang, Pavan Reddy
Publikováno v:
Blood Advances, Vol 1, Iss 19, Pp 1517-1532 (2017)
Abstract: Inhibitors of apoptosis proteins (IAPs) regulate apoptosis, but little is known about the role of IAPs in the regulation of immunity. Development of IAP inhibition by second mitochondria-derived activator of caspase (SMAC) mimetics is emerg
Externí odkaz:
https://doaj.org/article/632e22980f744ac7bf781a6d90726561
Autor:
Min Zhuang, Sharan R. Srinivasan, Colin S. Duckett, Laura C. Cesa, Xiaokai Li, James A. Wells, Ivan Maillard, Jason E. Gestwicki, Olivier Julien, Jooho Chung, Hao Shao
Publikováno v:
Molecular cancer research : MCR, vol 16, iss 1
Hsp70 is a molecular chaperone that binds to “client” proteins and protects them from protein degradation. Hsp70 is essential for the survival of many cancer cells, but it is not yet clear which of its clients are involved. Using structurally dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7553d21e9ac46993f8e867d39ef496af
https://escholarship.org/uc/item/23j7187d
https://escholarship.org/uc/item/23j7187d
Autor:
Andrew J. Kocab, Colin S. Duckett
Publikováno v:
FEBS Journal. 283:221-231
The inhibitor of apoptosis (IAP) proteins have often been considered inhibitors of cell death due to early studies describing their ability to directly bind and inhibit caspases, the primary factors that implement apoptosis. However, a greater unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ba134b02f6604cf49f10985f55d613
https://doi.org/10.1111/febs.13554
https://doi.org/10.1111/febs.13554
Autor:
Kevin K. Kim, Shaomeng Wang, Amanda K. Wheaton, Natalya Subbotina, Thomas H. Sisson, Carol A. Wilke, Iyabode O. Ajayi, Colin S. Duckett, Shanna L. Ashley, Bethany B. Moore, Jeffrey C. Horowitz
Accumulation of apoptosis-resistant fibroblasts is a hallmark of pulmonary fibrosis. We hypothesized that disruption of inhibitor of apoptosis protein (IAP) family proteins would limit lung fibrosis. We first show that transforming growth factor-β1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3439ddcfed3697d084890d19425b48
https://europepmc.org/articles/PMC4821054/
https://europepmc.org/articles/PMC4821054/
Autor:
Elizabeth D. Hughes, J. Michael Younger, Colin S. Duckett, Philip A. Barker, Danielle Marcotte, Thomas L. Saunders, Niall S. Kenneth
Publikováno v:
Biochemical Journal. 443:355-359
A recent study revealed that ES (embryonic stem) cell lines derived from the 129 murine strain carry an inactivating mutation within the caspase 11 gene (Casp4) locus [Kayagaki, Warming, Lamkanfi, Vande Walle, Louie, Dong, Newton, Qu, Liu, Heldens, Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d9623ee14c5bfa84e4f590375dc4a6
https://doi.org/10.1042/bj20120249
https://doi.org/10.1042/bj20120249
Autor:
Kojo S.J. Elenitoba-Johnson, Xuwen Liu, Graham F. Brady, Jonathan D. Gitlin, Colin S. Duckett, Stefanie Galbán, Venkatesha Basrur, Thomas E. Wilson
Publikováno v:
Molecular and Cellular Biology. 30:1923-1936
In order to balance the cellular requirements for copper with its toxic properties, an elegant set of mechanisms has evolved to regulate and buffer intracellular copper. The X-linked inhibitor of apoptosis (XIAP) protein was recently identified as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d910a395df257fcee861ff6bf620195d
https://doi.org/10.1128/mcb.00900-09
https://doi.org/10.1128/mcb.00900-09
Autor:
Stefanie Galbán, Colin S. Duckett
Publikováno v:
Cell Death & Differentiation. 17:54-60
The ability of the vertebrate X-linked inhibitor of apoptosis (XIAP) protein to directly suppress apoptotic cell death pathways has been the subject of much research. Studies of this broadly expressed protein have largely focused on the unique intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc1e60b46928d3fe8eb1183c9169c53
https://doi.org/10.1038/cdd.2009.81
https://doi.org/10.1038/cdd.2009.81
Autor:
Young Eun Choi, Shawn B. Bratton, Michael Butterworth, Gerald M. Cohen, Colin S. Duckett, Srinivas Malladi
Publikováno v:
Journal of Biological Chemistry. 284:12772-12782
Inhibitor of apoptosis (IAP) proteins are widely expressed throughout nature and suppress cell death under a variety of circumstances. X-linked IAP, the prototypical IAP in mammals, inhibits apoptosis largely through direct inhibition of the initiato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd83a5135773222b19aeba8b1f6804f3
https://doi.org/10.1074/jbc.m807550200
https://doi.org/10.1074/jbc.m807550200
Publikováno v:
Biochemical Journal
c-IAP1 (cellular inhibitor of apoptosis 1) has recently emerged as a negative regulator of the non-canonical NF-κB (nuclear factor κB) signalling cascade. Whereas synthetic IAP inhibitors have been shown to trigger the autoubiquitination and degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39af7a35a6eeeaf816d8bab3cea373a4
http://europepmc.org/articles/PMC2677214
http://europepmc.org/articles/PMC2677214