Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Colin R Goding"'
Autor:
María Gutiérrez-Salmerón, José Manuel García-Martínez, Javier Martínez-Useros, María Jesús Fernández-Aceñero, Benoit Viollet, Severine Olivier, Jagat Chauhan, Silvia R Lucena, Antonio De la Vieja, Colin R Goding, Ana Chocarro-Calvo, Custodia García-Jiménez
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000732 (2020)
Coordination of gene expression with nutrient availability supports proliferation and homeostasis and is shaped by protein acetylation. Yet how physiological/pathological signals link acetylation to specific gene expression programs and whether such
Externí odkaz:
https://doaj.org/article/d6b95076bfc94e6c82999824a59bfd60
Autor:
Elizabeth A Coe, Jennifer Y Tan, Michael Shapiro, Pakavarin Louphrasitthiphol, Andrew R Bassett, Ana C Marques, Colin R Goding, Keith W Vance
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008501 (2019)
The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing evidence of the contribution of long noncoding RNAs (lncRNAs) in cancer, including melanoma, thei
Externí odkaz:
https://doaj.org/article/b5750b702ac44908b4d02ca83fd30566
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39752- (2024)
The major cause of death in cancer patients is a combination of metastatic dissemination combined with therapy resistance. Over recent years, intratumour phenotypic heterogeneity arising from the bi-directional interplay between plastic cancer cells
Externí odkaz:
https://doaj.org/article/de53395a47e144b0be27165c63f488ef
Autor:
Cang Li, Zhengyu Wang, Licheng Yao, Xingyu Lin, Yongping Jian, Yujia Li, Jie Zhang, Jingwei Shao, Phuc D. Tran, James R. Hagman, Meng Cao, Yusheng Cong, Hong-yu Li, Colin R. Goding, Zhi-Xiang Xu, Xuebin Liao, Xiao Miao, Rutao Cui
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sensitive will provide a significant
Externí odkaz:
https://doaj.org/article/d2b0cc08f5634978acf720d5bf955d80
Autor:
Koichiro Kumano, Hiromitsu Nakahashi, Pakavarin Louphrasitthiphol, Yukihito Kuroda, Yoshihiro Miyazaki, Osamu Shimomura, Shinji Hashimoto, Yoshimasa Akashi, Bryan J. Mathis, Jaejeong Kim, Yohei Owada, Colin R. Goding, Tatsuya Oda
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is especially hypoxic and composed of heterogeneous cell populations containing hypoxia-adapted cells. Hypoxia as a microenvironment of PDAC is known to cause epithelial-mesenchymal transition (EMT) and resista
Externí odkaz:
https://doaj.org/article/ce16ec85cbab42f69baaac534345d5f7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Melanoma is a complex and aggressive cancer type that contains different cell subpopulations displaying distinct phenotypes within the same tumor. Metabolic reprogramming, a hallmark of cell transformation, is essential for melanoma cells to adopt di
Externí odkaz:
https://doaj.org/article/66b925728e6d4485a6eca85895b1aae9
Autor:
Romuald Binet, Jean-Philippe Lambert, Marketa Tomkova, Samuel Tischfield, Arianna Baggiolini, Sarah Picaud, Sovan Sarkar, Pakavarin Louphrasitthiphol, Diogo Dias, Suzanne Carreira, Timothy Humphrey, Panagis Fillipakopoulos, Richard White, Colin R Goding
Publikováno v:
bioRxiv
Since genome instability can drive cancer initiation and progression, cells have evolved highly effective and ubiquitous DNA Damage Response (DDR) programs. However, some cells, in skin for example, are normally exposed to high levels of DNA damaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8077809c8f9e8371143195540c9dd203
https://ora.ox.ac.uk/objects/uuid:b319581f-ffe5-40fe-b003-8e65f4163eb7
https://ora.ox.ac.uk/objects/uuid:b319581f-ffe5-40fe-b003-8e65f4163eb7
Autor:
Shuyang Chen, Colin R. Goding, Joshua Arbesman, Ying Ni, Xianfang Wu, Ershang Liang, Judy Zhang, Chengqian Yin, Xin Li, Yu Sun
Figure S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3e818bd35a2598423f4ce9c21dae11
https://doi.org/10.1158/0008-5472.22549655
https://doi.org/10.1158/0008-5472.22549655
Autor:
Shuyang Chen, Colin R. Goding, Joshua Arbesman, Ying Ni, Xianfang Wu, Ershang Liang, Judy Zhang, Chengqian Yin, Xin Li, Yu Sun
Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63240f2082f19cc8d56137327dae943c
https://doi.org/10.1158/0008-5472.c.6487380.v1
https://doi.org/10.1158/0008-5472.c.6487380.v1
Autor:
H. Matthew Berns, Dawn E. Watkins-Chow, Sizhu Lu, Pakavarin Louphrasitthiphol, Tongwu Zhang, Kevin M. Brown, Pedro Moura-Alves, Colin R. Goding, William J. Pavan
Publikováno v:
bioRxiv
The human Red Hair Color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f9a6c475a593a4c770140e150b2f73
https://europepmc.org/articles/PMC10120706/
https://europepmc.org/articles/PMC10120706/