Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Colin R Butler"'
Autor:
Johnny Kenth, Elizabeth Maughan, Colin R Butler, Jasleen Gabrie, Maral Rouhani, Benjamin Silver, Olumide K Ogunbiyi, Stuart Wilkinson, Reema Nandi, Robert Walker, Nagarajan Muthialu, Simon Jones, Richard Hewitt, Iain A Bruce
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Mucopolysaccharidosis (MPS) type IVA is a rare lysosomal storage disorder caused by aberrations of the N-acetyl-galactosamine-6-sulfatase (GALNS) enzyme. MPS IVA is associated with a wide gamut of respiratory and airway disorders
Externí odkaz:
https://doaj.org/article/7834c7ec13d8457c9faf74eb47a221cb
Autor:
Robert E Hynds, Kate H C Gowers, Ersilia Nigro, Colin R Butler, Paola Bonfanti, Adam Giangreco, Cecilia M Prêle, Sam M Janes
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197129 (2018)
There is considerable interest in the ex vivo propagation of primary human basal epithelial stem/progenitor cells with a view to their use in drug development, toxicity testing and regenerative medicine. These cells can be expanded in co-culture with
Externí odkaz:
https://doaj.org/article/b579694b0efa4e9f85b9f71e90b89dba
Autor:
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N.J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105409- (2022)
Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related mole
Externí odkaz:
https://doaj.org/article/bc9bfc65a4564f5b8c32bca349dccceb
Autor:
Edward Hannon, Marco Pellegrini, Federico Scottoni, Natalie Durkin, Soichi Shibuya, Roberto Lutman, Toby J. Proctor, J. Ciaran Hutchinson, Owen J. Arthurs, Demetra-Ellie Phylactopoulos, Elizabeth F. Maughan, Colin R. Butler, Simon Eaton, Mark W. Lowdell, Paola Bonfanti, Luca Urbani, Paolo De Coppi
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105174- (2022)
Summary: Decellularization of esophagi from several species for tissue engineering is well described, but successful implantation in animal models of esophageal replacement has been challenging. The purpose of this study was to assess feasibility and
Externí odkaz:
https://doaj.org/article/e4991bd0c49541dc872eda47ebf1df19
Autor:
Claire Frauenfelder, Susan C. Shelmerdine, Ian C. Simcock, Andrew Hall, John Ciaran Hutchinson, Michael T. Ashworth, Owen J. Arthurs, Colin R. Butler
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Objectives: To determine the feasibility of micro-CT as a high-resolution 3D imaging tool for thyroglossal duct cysts and to evaluate its role augmenting traditional histopathological examination of resected specimens.Methods: A single centre, prospe
Externí odkaz:
https://doaj.org/article/38af1a8e1a5e456d88bd75ac9be00a51
Autor:
Maximillian Woodall, Ana-Maria Cujba, Kaylee B. Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G. H. Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D. McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O’Callaghan, Jie Zhou, Wendy Barclay, Paolo De Coppi, Colin R. Butler, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C. Chambers, Wendy E. Heywood, Kevin Mills, Robert E. Hynds, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić, Claire M. Smith
Children infected with SARS-CoV-2 rarely progress to respiratory failure, but the risk of mortality in infected people over 85 years of age remains high, despite vaccination and improving treatment options. Here, we take a comprehensive, multidiscipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d879062a84c842d555af5dd10e4eba88
https://doi.org/10.1101/2023.01.16.524211
https://doi.org/10.1101/2023.01.16.524211
Autor:
Peter J. Campbell, Adam Pennycuick, Inigo Martincorena, Kenichi Yoshida, Andrew Menzies, Tomonori Hirano, Ricky Thakrar, Sarah E. Clarke, Nobuyuki Kakiuchi, Colin R. Butler, Henry Lee-Six, Sam M. Janes, Kathryn Beal, Tim H. H. Coorens, Elizabeth Anderson, Michael R. Stratton, Kate H.C. Gowers, Elizabeth F. Maughan, Robert E. Hynds, Fraser R. Millar, Deepak P. Chandrasekharan
Publikováno v:
Nature. 578:266-272
Tobacco smoking causes lung cancer1–3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6–10, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd71989032b18cec95132d877481f7c
https://doi.org/10.1038/s41586-020-1961-1
https://doi.org/10.1038/s41586-020-1961-1
Autor:
Tarek E. Abdel-Aziz, Joan Sancho-Insenser, Antonio Sitges-Serra, Mechteld C. de Jong, Colin R. Butler, Richard Hewitt, Tom R. Kurzawinski, Caroline Brain, Virginia Rozalén García, Leyre Lorente-Poch
Publikováno v:
Hormone Research in Paediatrics. 93:539-547
Background: Parathyroid failure after total thyroidectomy is the commonest adverse event amongst both children and adults. The phenomenon of late recovery of parathyroid function, especially in young patients with persistent hypoparathyroidism, is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c30451a6b834aaba6155836cc1816d1
https://doi.org/10.1159/000513768
https://doi.org/10.1159/000513768
Autor:
Rgh Lindeboom, BC Jones, Muzlifah Haniffa, Laura Richardson, C Dominguez Conde, JP Pett, Sean B. Smith, Elo Madissoon, V Chu, Ca Gao, Aarash Saleh, Sarah Teichmann, Krzysztof Polanski, Eliz Kilich, A-K Reuschl, Jessica Allen-Hyttinen, Neil J. Sebire, Kerstin B. Meyer, H Yung, Alexander V. Misharin, A Saigal, Clatworthy, Clare Jolly, Jane Dematte, Waradon Sungnak, C Cane, Marko Nikolic, Colin R. Butler, Ni Huang, Puja Mehta, Claire Smith, Elena Prigmore, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Taylor A. Poor, Josephine Barnes, S Shibuya, NU Script Study Investigators, Kaylee B Worlock, AC Argento, Anna Wilbrey-Clark, A Iordanidou, Sam M. Janes, P De Coppi, Matthew L Coates, Jonathan M. Cohen, Liam Bolt, Lira Mamanova, Masahiro Yoshida, Berthold Göttgens, Gary Reynolds, Richard G. Wunderink, Christopher O'Callaghan, Georgina Bowyer, A de Wilton
Publikováno v:
BTS/BALR/AUK-BLF Early Career Investigator Symposium.
T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aad24e6918d8a981a5285a5a1044e38
https://doi.org/10.1136/thorax-2021-btsabstracts.1
https://doi.org/10.1136/thorax-2021-btsabstracts.1