Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Colin Platt"'
Autor:
Richard G. Lee, Anne Marie Mazzola, Maurine C. Braun, Colin Platt, Scott B. Vafai, Sekar Kathiresan, Ellen Rohde, Andrew M. Bellinger, Amit V. Khera
Publikováno v:
Circulation. 147:242-253
Background: VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the PCSK9 gene, permanently turn off hepatic protein production, and thereby durably lower low-density lipoprotein cholesterol. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cea7c8e0c4f3884a380b85f18cf2c81
https://doi.org/10.1161/circulationaha.122.062132
https://doi.org/10.1161/circulationaha.122.062132
Autor:
Jason D. Roh, Robert R. Kitchen, J. Sawalla Guseh, Jenna N. McNeill, Malika Aid, Amanda J. Martinot, Andy Yu, Colin Platt, James Rhee, Brittany Weber, Lena E. Trager, Margaret H. Hastings, Sarah Ducat, Peng Xia, Claire Castro, Abhilasha Singh, Bjarni Atlason, Timothy W. Churchill, Marcelo F. Di Carli, Patrick T. Ellinor, Dan H. Barouch, Jennifer E. Ho, Anthony Rosenzweig
Publikováno v:
JACC: Basic to Translational Science. 7:425-441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c5c6c09a70bb9b3d8530793c7702ec7
https://doi.org/10.1016/j.jacbts.2022.01.013
https://doi.org/10.1016/j.jacbts.2022.01.013
Autor:
Richard G, Lee, Anne Marie, Mazzola, Maurine C, Braun, Colin, Platt, Scott B, Vafai, Sekar, Kathiresan, Ellen, Rohde, Andrew M, Bellinger, Amit V, Khera
Publikováno v:
Circulation.
VERVE-101 is an investigationalCynomolgus monkeys were dosed with a single intravenous infusion of a vehicle control (N=10) or VERVE-101 at a dose of 0.75 mg/kg (N=4) or 1.5 mg/kg (N=22) with subsequent follow-up out to 476 days. Two studies assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5c630b45b443ab27df363ebec1f452f
https://pubmed.ncbi.nlm.nih.gov/36314243
https://pubmed.ncbi.nlm.nih.gov/36314243
Autor:
Lena E Trager, Alexandra Kuznetsov, Margaret Lyons, Yoshiko Iwamoto, Robert Kitchen, Carolin Lerchenmueller, Colin Platt, James S Guseh, Nicholas Houstis, Haobo Li, Anthony Rosenzweig
Publikováno v:
Circulation. 144
Introduction: CITED4 (CBP/p300-interacting transactivators with E [glutamic acid]/D [aspartic acid]-rich-carboxylterminal domain 4) is a transcriptional regulator which limits pathologic remodeling after ischemic and pressure overload models of cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb51f0ac9ef463387e46bc0c4f35e0f4
https://doi.org/10.1161/circ.144.suppl_1.13218
https://doi.org/10.1161/circ.144.suppl_1.13218
Autor:
Jason D, Roh, Robert R, Kitchen, J Sawalla, Guseh, Jenna N, McNeill, Malika, Aid, Amanda J, Martinot, Andy, Yu, Colin, Platt, James, Rhee, Brittany, Weber, Lena E, Trager, Margaret H, Hastings, Sarah, Ducat, Peng, Xia, Claire, Castro, Abhilasha, Singh, Bjarni, Atlason, Timothy W, Churchill, Marcelo F, Di Carli, Patrick T, Ellinor, Dan H, Barouch, Jennifer E, Ho, Anthony, Rosenzweig
Publikováno v:
JACC. Basic to translational science. 7(5)
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94e77a8713dec9aa89b3267212dc862d
https://pubmed.ncbi.nlm.nih.gov/35663631
https://pubmed.ncbi.nlm.nih.gov/35663631
Autor:
Timothy W. Churchill, Brittany Weber, Claire Castro, Anthony Rosenzweig, Dan H. Barouch, Jenna McNeill, Jennifer E. Ho, Andy Yu, Sarah Ducat, Patrick T. Ellinor, Malika Aid, Margaret H. Hastings, Robert R. Kitchen, Jason D. Roh, Amanda J. Martinot, James Rhee, Marcelo F. Di Carli, Lena E Trager, Peng Xia, J. Sawalla Guseh, Colin Platt, Bjarni Atlason
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4875e8a208fa0a112d14226a1d645f
https://doi.org/10.21203/rs.3.rs-539712/v1
https://doi.org/10.21203/rs.3.rs-539712/v1
Autor:
Charles P Rabolli, Carolin Lerchenmüller, Ane M. Salvador, Eva Riechert, Piyusha Kundu, Colin Platt, Steve Carr, Vassilios J. Bezzerides, Robert R. Kitchen, Jeffrey E. Saffitz, Hugo A. Katus, Federico Damilano, Saumya Das, Laura Liu, Ashish Yeri, Hasmik Keshishian, Ravi V. Shah, Anthony Rosenzweig, Kirsty Danielson, Olivia Ziegler
Publikováno v:
Circulation research. 127(5)
Rationale:Cardiac CITED4 is induced by exercise and is sufficient to cause physiological hypertrophy and mitigate adverse ventricular remodeling after ischemic injury. However, the role of endogenous CITED4 in response to physiological or pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b03d84fffbdaba8c72a84b7c71e6b85
https://pubmed.ncbi.nlm.nih.gov/32790523
https://pubmed.ncbi.nlm.nih.gov/32790523
Autor:
Jason D. Roh, Nicholas E. Houstis, Michael Jerosch-Herold, Ana Vujic, Ryan Hobson, Bliss J. Chang, Carolin Lerchenmüller, Vinita Chaudhari, Colin Platt, Haobo Li, Federico Damilano, Andy Yu, Ashish Yeri, Daniel A. Zlotoff, Ravi V. Shah, Anthony Rosenzweig, Richard T. Lee
Publikováno v:
Aging Cell
Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b61ae7ddd25eb7458552689955d97da
https://pubmed.ncbi.nlm.nih.gov/32441410
https://pubmed.ncbi.nlm.nih.gov/32441410
Autor:
Christine E. Seidman, Se-Jin Lee, Jonathan G. Seidman, Sammy Elmariah, Federico Damilano, Nicholas E. Houstis, Anthony Rosenzweig, Vassilios J. Bezzerides, Vinita Chaudhari, Estelle Lach-Trifilieff, David J. Glass, Colin Platt, Jason D. Roh, Ryan Hobson, Chunyang Xiao, Ashish Yeri, Daniel A. Zlotoff, Mark D. Benson, Brian R. Lindman, Pablo A. Quintero, Robert E. Gerszten, Michael Biersmith
Publikováno v:
Science translational medicine, vol 11, iss 482
Activin type II receptor (ActRII) ligands have been implicated in muscle wasting in aging and disease. However, the role of these ligands and ActRII signaling in the heart remains unclear. Here, we investigated this catabolic pathway in human aging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbffe82e1fdbdf4f79c49bc7ff78791
https://escholarship.org/uc/item/8kt0f4k7
https://escholarship.org/uc/item/8kt0f4k7
Autor:
Colin Platt
Publikováno v:
Medieval Archaeology. 60:300-310
WHILE ARCHAEOLOGISTS are well informed about plague and climate change, many are less familiar with the emergence in pre-plague England of a vigorous market in peasant land in which both freemen and villeins were represented. Yet the tenant’s growi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77bb39d72311b2ced9684ee968a29fb
https://doi.org/10.1080/00766097.2016.1221244
https://doi.org/10.1080/00766097.2016.1221244