Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Colin P. Green"'
Autor:
Chidinma Adanna Okolo, Jack Jonathan Maran, Amy Watts, Jaime Maripillan, Maria Harkiolaki, Agustín D. Martínez, Colin R. Green, Odunayo Omolola Mugisho
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e27888- (2024)
Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemi
Externí odkaz:
https://doaj.org/article/e17a063b57c24edb96e75c070ffc7e0f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Major neurocognitive disorder (NCD) affects over 55 million people worldwide and is characterized by cognitive impairment (CI). This study aimed to develop a non-invasive diagnostic test for CI based upon retinal thickness measurements explo
Externí odkaz:
https://doaj.org/article/5b6109bf831c467fafbcffaec98ea513
Autor:
Andrea Kwakowsky, Bhavya Chawdhary, Antonio de Souza, Emily Meyer, Andrew H. Kaye, Colin R. Green, Stanley S. Stylli, Helen Danesh-Meyer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17454 (2023)
Multiple sclerosis (MS) is a neurodegenerative disease marked by chronic neuroinflammation thought to be mediated by the inflammasome pathway. Connexin 43 (Cx43) hemichannels contribute to the activation of the inflammasome through the release of ade
Externí odkaz:
https://doaj.org/article/2b3851cfeb9c4ffcb3730ef63a5aeaf5
Autor:
Monica L Acosta, Mohd N Mat Nor, Cindy X Guo, Odunayo O Mugisho, Frazer P Coutinho, Ilva D Rupenthal, Colin R Green
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 3, Pp 482-488 (2021)
Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclus
Externí odkaz:
https://doaj.org/article/6936317373df49b08ec1697f0703eba8
Autor:
Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine
Externí odkaz:
https://doaj.org/article/cbf3b5a17eb140fdbcaac434c1479c5c
Autor:
Odunayo O. Mugisho, Jyoti Aryal, Avik Shome, Heather Lyon, Monica L. Acosta, Colin R. Green, Ilva D. Rupenthal
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3876 (2023)
Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with pronounced inflammation arising from the activation of a nucleotide-binding and oligomerization domain-like receptor (NLR) protein 3 (NLRP3) inflammasome. Cell cu
Externí odkaz:
https://doaj.org/article/3e6379f591b04eedb363173a8620e918
Autor:
Alice McDouall, Kelly Q. Zhou, Laura Bennet, Colin R. Green, Alistair J. Gunn, Joanne O. Davidson
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1445 (2022)
Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or
Externí odkaz:
https://doaj.org/article/d5526f8b4b114136b9f8ef2939ea54b5
Autor:
Robert Galinsky, Joanne O Davidson, Justin M Dean, Colin R Green, Laura Bennet, Alistair J Gunn
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 2, Pp 181-189 (2018)
Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy. Therapeutic hypothermia is now well established to partially reduce risk of disability in late preterm/term infants. However, new and complementary therapeutic targ
Externí odkaz:
https://doaj.org/article/b60622fb42b948f19251ec3035272529
Autor:
Robert Galinsky, Joanne O. Davidson, Christopher A. Lear, Laura Bennet, Colin R. Green, Alistair J. Gunn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Basal ganglia injury at term remains a major cause of disability, such as cerebral palsy. In this study we tested the hypotheses that blockade of astrocytic connexin hemichannels with a mimetic peptide would improve survival of striatal phen
Externí odkaz:
https://doaj.org/article/4bfffef3cd43417bb9db4658a06b47c1
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain injury is typically associated with hypoxia-ischemia and/or infection/inflammation. Both hypoxia-ischemia and infection trigger an inflammatory response i
Externí odkaz:
https://doaj.org/article/d1e4ac8f3a6c4874a8b16fff0d7d4a3c