Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Colin P, Sibley"'
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Hypertension during pregnancy is a leading cause of maternal and fetal morbidity and mortality worldwide, increasing the risk of complications including preeclampsia, intracerebral hemorrhage and fetal growth restriction. Increased oxidative stress i
Externí odkaz:
https://doaj.org/article/8035d1c5e7414489a16524f97932ee8f
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction
Autor:
Lewis J. Renshall, Frances Beards, Angelos Evangelinos, Susan L. Greenwood, Paul Brownbill, Adam Stevens, Colin P. Sibley, John D. Aplin, Edward D. Johnstone, Tambet Teesalu, Lynda K. Harris
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1778 (2021)
Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects i
Externí odkaz:
https://doaj.org/article/31d09fe8761e42b3bf935d5bee54fcfc
Autor:
Emily Angiolini, Ionel Sandovici, Philip M. Coan, Graham J. Burton, Colin P. Sibley, Abigail L. Fowden, Miguel Constância
Publikováno v:
Genes, Vol 12, Iss 5, p 639 (2021)
Genomic imprinting, an epigenetic phenomenon that causes the expression of a small set of genes in a parent-of-origin-specific manner, is thought to have co-evolved with placentation. Many imprinted genes are expressed in the placenta, where they pla
Externí odkaz:
https://doaj.org/article/7fadd2f2f7934677987b6fda5e93dc44
Autor:
Teresa Tropea, Carina Nihlen, Eddie Weitzberg, Jon O. Lundberg, Mark Wareing, Susan L. Greenwood, Colin P. Sibley, Elizabeth C. Cottrell
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4500 (2021)
Nitric oxide (NO) is essential in the control of fetoplacental vascular tone, maintaining a high flow−low resistance circulation that favors oxygen and nutrient delivery to the fetus. Reduced fetoplacental blood flow is associated with pregnancy co
Externí odkaz:
https://doaj.org/article/80e288e6e92949b8bdf93714ca41f436
Autor:
Christina E. Hayward, Kirsty R. McIntyre, Colin P. Sibley, Susan L. Greenwood, Mark R. Dilworth
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Fetal delivery of calcium, via the placenta, is crucial for appropriate skeletal mineralization. We have previously demonstrated that maternofetal calcium transport, per gram placenta, is increased in the placental specific insulin-like growth factor
Externí odkaz:
https://doaj.org/article/2951346d3ef04ddd807d1fd454642d5c
Autor:
Sarah L. Finn-Sell, Elizabeth C. Cottrell, Susan L. Greenwood, Mark R. Dilworth, Elizabeth J. Cowley, Colin P. Sibley, Mark Wareing
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The eNOS−/− mouse provides a well-characterized model of fetal growth restriction (FGR) with altered uterine and umbilical artery function and reduced utero- and feto-placental blood flow. Pomegranate juice (PJ), which is rich in antioxidants and
Externí odkaz:
https://doaj.org/article/fcf4171050bd42d593c6677844dc6bb2
Autor:
Lewis J. Renshall, Hannah L. Morgan, Hymke Moens, David Cansfield, Sarah L. Finn-Sell, Teresa Tropea, Elizabeth C. Cottrell, Susan Greenwood, Colin P. Sibley, Mark Wareing, Mark R. Dilworth
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Fetal growth restriction (FGR) presents with an increased risk of stillbirth and childhood and adulthood morbidity. Melatonin, a neurohormone and antioxidant, has been suggested as having therapeutic benefit in FGR. We tested the hypothesis that mela
Externí odkaz:
https://doaj.org/article/001dd148ca554683ba44807efe0e4d74
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206533 (2018)
OBJECTIVE:To assess the value of in utero placental assessment in predicting adverse pregnancy outcome after reported reduced fetal movements (RFM). METHOD:A non-interventional prospective cohort study of women (N = 300) with subjective RFM at ≥28
Externí odkaz:
https://doaj.org/article/eee86a2645ae47d7936b42b0a3e3ab15
Autor:
Christina E. Hayward, Lewis J. Renshall, Colin P. Sibley, Susan L. Greenwood, Mark R. Dilworth
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Appropriate placental transport of calcium is essential for normal fetal skeletal mineralization. In fetal growth restriction (FGR), the failure of a fetus to achieve its growth potential, a number of placental nutrient transport systems show reduced
Externí odkaz:
https://doaj.org/article/77bbaabc79194020806877e5fb63ba23
Autor:
Elizabeth C. Cottrell, Colin P. Sibley
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 12907-12924 (2015)
Complications of pregnancy represent a significant disease burden, with both immediate and lasting consequences for mother and baby. Two key pregnancy complications, fetal growth restriction (FGR) and preeclampsia (PE), together affect around 10%–1
Externí odkaz:
https://doaj.org/article/dbcaf1206445408584e08aee50c09bf9