Zobrazeno 1 - 2
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pro vyhledávání: '"Colin P, Leslie"'
Autor:
Steven M, Bromidge, Roberto, Arban, Barbara, Bertani, Silvia, Bison, Manuela, Borriello, Paolo, Cavanni, Giovanna, Dal Forno, Romano, Di-Fabio, Daniele, Donati, Stefano, Fontana, Massimo, Gianotti, Laurie J, Gordon, Enrica, Granci, Colin P, Leslie, Luca, Moccia, Alessandra, Pasquarello, Ilaria, Sartori, Anna, Sava, Jeannette M, Watson, Angela, Worby, Laura, Zonzini, Valeria, Zucchelli
Publikováno v:
Journal of medicinal chemistry. 53(15)
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT(1A/B/D) receptor antagonists with and w
Autor:
Ian Fleming, Colin P. Leslie
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1197
The pentadienylsilane 9 and the dimethyl acetal 2 of isobutyraldehyde react with high (80:20)anti stereospecificity to give largely the diene 10a, which was converted into the para-disubstituted benzene 11a, having 1,6-related stereogenic centres.