Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Colin Masui"'
Autor:
Colin Masui, Peter Yehl, Chong Han, Kelly Zhang, Francis Gosselin, Lauren E. Sirois, Alexandre Goyon
Publikováno v:
Analytical Chemistry. 92:15187-15193
Automated high-throughput experimentation (HTE) is a powerful tool for scientists to explore and optimize chemical transformations by simultaneously screening yield, stereoselectivity, and impurity profiles. To analyze the HTE samples, high-throughpu
Publikováno v:
International Journal of Pharmaceutics. 521:337-345
This paper explores the effectiveness of resonant acoustic mixing RAM for screening and scale up of cocrystals. 16 cocrystal systems were selected as test cases based on previous literature precedent. A 96 well plate set up in conjunction with zircon
Autor:
Andrew McClory, Christoph Ochs, Sarah J. Robinson, Pankaj D. Rege, Ngiap-Kie Lim, Theresa Cravillion, Francis Gosselin, Haiming Zhang, Scott A. Savage, Chong Han, Colin Masui
Publikováno v:
The Journal of organic chemistry. 83(19)
We report an efficient synthesis of GDC-0810 on the basis of a sequence involving a highly stereoselective lithium tert-butoxide-mediated enolization–tosylation (≥95:5 E:Z) and a Pd-catalyzed Suzuki–Miyaura cross-coupling as key steps. Global d
Autor:
Jane L. Grogan, Ruina Li, Edna F. Choo, Sarah M. Bronner, Maureen Beresini, Jonathan Maher, Patrick Cyr, Yingjie Li, Thomas Hunsaker, Brian K. Albrecht, Colin Masui, Kevin R Clark, Yingqing Ran, Jeremy Murray, Terry Crawford, Xiaorong Liang, Fei Wang, F. Anthony Romero, Xiaocang Wei, Alexander M. Taylor, Georgia Hatzivassiliou, Kyle Clagg, Kwong Wah Lai, Karen E. Gascoigne, Le An, Steven Magnuson, Mark Merchant, John S. Wai, Zhongguo Chen, Jiangpeng Liao, Vickie Tsui, Emily Chan, Kevin X. Chen, Wenfeng Liu, Wei Huang, Dong Yu, Stefan G. Koenig, Susan Kaufman, Xiaoyu Zhu, Gladys de Leon Boenig, Justin Ly, Denise E. de Almeida Nagata, Bing-Yan Zhu
Publikováno v:
Journal of medicinal chemistry. 60(22)
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent a