Ebola Virus Glycoprotein Counteracts BST-2/Tetherin Restriction in a Sequence-Independent Manner That Does Not Require Tetherin Surface Removal

Autor: Kevin G. Haworth, Lisa A Lopez, Heiko Hauser, Jill Oldenburg, Colin M. Exline, Paula M. Cannon, Su Jung Yang

Publikováno v: Journal of Virology. 84:7243-7255

BST-2/tetherin is an interferon-inducible protein that restricts the release of enveloped viruses from the surface of infected cells by physically linking viral and cellular membranes. It is present at both the cell surface and in a perinuclear regio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c638926197eccc3aa36996414bbb7268
https://doi.org/10.1128/jvi.02636-09

Using Engineered Nucleases to Create HIV-Resistant Cells

Autor: Nathalia Holt, Paula M. Cannon, Colin M. Exline, George N. Llewellyn

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781493935079

HIV-1/AIDS is often considered a priority disease in the development of genetic and cell based therapies because of the high burden imposed by current treatments, which require life-long adherence to antiretroviral drug regimens. Engineered nucleases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5096320a3d74d82b958056897e3013e6
https://doi.org/10.1007/978-1-4939-3509-3_10

Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening

Autor: Jessica Y. Rathbun, Jill Henley, Kevin G. Haworth, Colin M. Exline, Paula M. Cannon, Magali E. Droniou, Robert Damoiseaux, Hyeryun Choe

Publikováno v: Journal of virology, vol 89, iss 16
Rathbun, JY; Droniou, ME; Damoiseaux, R; Haworth, KG; Henley, JE; Exline, CM; et al.(2015). Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. JOURNAL OF VIROLOGY, 89(16), 8428-8443. doi: 10.1128/JVI.00997-15. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7k38j6fq

Certain members of the Arenaviridae family are category A agents capable of causing severe hemorrhagic fevers in humans. Specific antiviral treatments do not exist, and the only commonly used drug, ribavirin, has limited efficacy and can cause severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59959f4225ea24b47bc31dfe55f86597
https://escholarship.org/uc/item/7k38j6fq

478. Highly Efficient Targeted Gene Addition in CD34+ Hematopoietic Stem/Progenitor Cells by Combining ZFN mRNA and AAV6 Donor Delivery

Autor: Josh DeClercq, Paula M. Cannon, Colin M. Exline, Philip D. Gregory, Jianbin Wang, Michael C. Holmes, Patrick Li

Publikováno v: Molecular Therapy. 23

Zinc-finger nucleases (ZFNs) drive highly efficient genome editing by generating a site-specific DNA double-strand break (DSB) at a predetermined site in the genome. Subsequent repair of this break via the non-homologous end-joining (NHEJ) or homolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe626ca300bee16edcf67615ccd6409b

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

Autor: John A. Zaia, Michael C. Holmes, Jianbin Wang, David DiGiusto, Gary Lee, Rodica Stan, Nancy Gonzalez, Anitha Rao, Samuel B. Hayward, Paula M. Cannon, Kathleen Meyer, Kenneth Kim, Victoria Bedell, Colin M. Exline, Jill Henley, Philip D. Gregory, Lijing Li, Evan Lopez

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)

Gene therapy for HIV-1 infection is a promising alternative to lifelong combination antiviral drug treatment. Chemokine receptor 5 (CCR5) is the coreceptor required for R5-tropic HIV-1 infection of human cells. Deletion of CCR5 renders cells resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6db6d6edeeda31387f07c306cb4c4
http://europepmc.org/articles/PMC5102145