Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Colin M. Cleary"'
Autor:
Colin M. Cleary, Jack L. Browning, Moritz Armbruster, Cleyton R. Sobrinho, Monica L. Strain, Sarvin Jahanbani, Jaseph Soto-Perez, Virginia E. Hawkins, Chris G. Dulla, Michelle L. Olsen, Daniel K. Mulkey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+. Considering Kir4.1/5.1 channels are CO2/H+-sensitive and important for several astro
Externí odkaz:
https://doaj.org/article/1f960e43c3b940399d7ba13f775dde08
Autor:
Colin M. Cleary, PhD, Maleek Masood, BS, Mina L. Boutrous, MD, RPVI, Kwame S. Amankwah, MD, RPVI
Publikováno v:
Journal of Vascular Surgery Cases and Innovative Techniques, Vol 8, Iss 4, Pp 736-739 (2022)
Aneurysmal pelvic arteriovenous malformations in male patients are exceptionally rare. Upon spontaneous or traumatic rupture, these aneurysms can cause severe hemorrhage and are often associated with high mortality. Given that most intact aneurysms a
Externí odkaz:
https://doaj.org/article/a901dda02e564b5bb61cb49d18158de1
Autor:
Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, Daniel K Mulkey
Publikováno v:
eLife, Vol 10 (2021)
Glutamatergic neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating breathing in response to tissue CO2/H+. The RTN and greater parafacial region may also function as a chemosensing network composed of CO2/H
Externí odkaz:
https://doaj.org/article/a794c70933c444b69e808778ca8d0144
Autor:
Colin M Cleary, Thiago S Moreira, Ana C Takakura, Mark T Nelson, Thomas A Longden, Daniel K Mulkey
Publikováno v:
eLife, Vol 9 (2020)
Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+. Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to res
Externí odkaz:
https://doaj.org/article/9ff7d9f1713040c0874ea849ac4d4a7e
Publikováno v:
eLife, Vol 8 (2019)
Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Respiratory failure is a leading cause of SUDEP, and DS patients’ frequently exhibit disordered breathing. Despite this, mechanisms und
Externí odkaz:
https://doaj.org/article/7de89762413e4415b7d278313cc29671
Autor:
Joseph F Bohlen, Colin M Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F Kenney, Ingrid P Buchler, Tapasree Banerji, Thomas S Scanlan, Daniel K Mulkey, Brady J Maher
Publikováno v:
Brain.
Pitt–Hopkins syndrome is an autism spectrum disorder caused by autosomal dominant mutations in the human transcription factor 4 gene (TCF4). One pathobiological process caused by murine Tcf4 mutation is a cell autonomous reduction in oligodendrocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::843f3974dec634234553a8ce35509265
https://doi.org/10.1093/brain/awad057
https://doi.org/10.1093/brain/awad057
Publikováno v:
Current Neuropharmacology. 20:5-15
General anesthetics are a mainstay of modern medicine, and although much progress has been made towards identifying molecular targets of anesthetics and neural networks contributing to endpoints of general anesthesia, our understanding of how anesthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897f1e55cc20efb2f045389c9c6959bb
https://doi.org/10.2174/1570159x19666210215120755
https://doi.org/10.2174/1570159x19666210215120755
Autor:
Virginia E Hawkins, Ana C Takakura, Ashley Trinh, Milene R Malheiros-Lima, Colin M Cleary, Ian C Wenker, Todd Dubreuil, Elliot M Rodriguez, Mark T Nelson, Thiago S Moreira, Daniel K Mulkey
Publikováno v:
eLife, Vol 6 (2017)
Cerebral blood flow is highly sensitive to changes in CO2/H+ where an increase in CO2/H+ causes vasodilation and increased blood flow. Tissue CO2/H+ also functions as the main stimulus for breathing by activating chemosensitive neurons that control r
Externí odkaz:
https://doaj.org/article/e55288af02364f69970fa8344cb83572
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Pitt-Hopkins syndrome (PTHS) is a rare autism spectrum-like disorder characterized by intellectual disability, developmental delays, and breathing problems involving episodes of hyperventilation followed by apnea. PTHS is caused by functional haploin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c0415e3441c6621b8a6e68a30e8a7
https://doi.org/10.1038/s41467-021-26263-2
https://doi.org/10.1038/s41467-021-26263-2
Autor:
Brenda M Milla, Daniel K Mulkey, Colin M Cleary, Paul Robson, Shaun James, Fu-Shan Kuo, William F. Flynn
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Glutamatergic neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating breathing in response to tissue CO2/H+. The RTN and greater parafacial region may also function as a chemosensing network composed of CO2/H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f30ff9c88012f087ea2706710dc3cc
https://elifesciences.org/articles/60317
https://elifesciences.org/articles/60317