Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Colin M, Tice"'
Autor:
Lori A. Emert-Sedlak, Haibin Shi, Colin M. Tice, Li Chen, John J. Alvarado, Sherry T. Shu, Shoucheng Du, Catherine E. Thomas, Jay E. Wrobel, Allen B. Reitz, Thomas E. Smithgall
Publikováno v:
Viruses, Vol 14, Iss 9, p 2025 (2022)
While antiretroviral drugs have transformed the lives of HIV-infected individuals, chronic treatment is required to prevent rebound from viral reservoir cells. People living with HIV also are at higher risk for cardiovascular and neurocognitive compl
Externí odkaz:
https://doaj.org/article/96ee558a12bf4bf9bcdc6cb09f66ff80
Autor:
Marianne Carlsen, Thomas E. Smithgall, Colin M. Tice, Wing Fai Li, Jay E. Wrobel, Haibin E. Shi, Allen B. Reitz, Li Chen, Lori A. Emert-Sedlak
Publikováno v:
ACS Infect Dis
The HIV-1 Nef accessory factor is critical to the viral life cycle in vivo and promotes immune escape of infected cells via downregulation of cell-surface MHC-I. Previously, we discovered small molecules that bind directly to Nef and block many of it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5199f957e7129e2a156492f237e1dd
https://doi.org/10.1021/acsinfecdis.9b00382
https://doi.org/10.1021/acsinfecdis.9b00382
Autor:
Barbara A. Kruk, Robert Cain, Richard D. Gregg, Suresh B. Singh, Dong Chengguo, Peter Lindblom, Linghang Zhuang, Liu Zhijie, Ya-Jun Zheng, Gerard McGeehan, David A. Claremon, Yi Zhao, Colin M. Tice, Deepak S. Lala
Publikováno v:
Journal of Chemical Information and Modeling. 59:3422-3436
With the continuous progress in ultralarge virtual libraries which are readily accessible, it is of great interest to explore this large chemical space for hit identification and lead optimization using reliable structure-based approaches. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a73b16847a98bc03cc59e741adf50f8
https://doi.org/10.1021/acs.jcim.9b00198
https://doi.org/10.1021/acs.jcim.9b00198
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2825-2837
In structure-based drug design, the basic goal is to design molecules that fit complementarily to a given binding pocket. Since such computationally modeled molecules may not adopt the intended bound conformation outside the binding pocket, one chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99783eabdbba03293c7152f211f1e32c
https://doi.org/10.1016/j.bmcl.2017.04.079
https://doi.org/10.1016/j.bmcl.2017.04.079
Publikováno v:
2017 Medicinal Chemistry Reviews ISBN: 9780996293242
2017 Medicinal Chemistry Reviews
2017 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb5ea0dd4c9298185996371d7482b3e
https://doi.org/10.29200/acsmedchemrev-v52.ch11
https://doi.org/10.29200/acsmedchemrev-v52.ch11
Autor:
Bradford S. Hamilton, Frank Himmelsbach, Barbara A. Kruk, Joan Guo, Gerard McGeehan, Peter Lindblom, Rong Guo, Colin M. Tice, Brian M. McKeever, Linghang Zhuang, David A. Claremon, Judith A. Johnson, Katerina Leftheris, Lamont Howard, Salvacion Cacatian, Heike Schauerte, Annette Schuler-Metz, Richard Gregg, Reshma Panemangalore, Deepak S. Lala, Paula Krosky, Zhenrong Xu, Yuri Bukhtiyarov, Suresh B. Singh, Yuanjie Ye, Yi Zhao, Wei Zhao, Shi Meng
Publikováno v:
Bioorganicmedicinal chemistry. 25(14)
A potent, in vivo efficacious 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) inhibitor (11j) has been identified. Compound 11j inhibited 11β HSD1 activity in human adipocytes with an IC50 of 4.3nM and in primary human adipose tissue with an IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a3ef85dcc22b2889fcf6062c9a383
https://pubmed.ncbi.nlm.nih.gov/28528082
https://pubmed.ncbi.nlm.nih.gov/28528082
Although spirocycles have been incorporated into drugs and explored in drug discovery for over five decades, recent years have seen a greater variety and number of spirocycles employed in drug discovery. This increase has been driven by improved synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8d2894faf7f34b293ea3f384452049
https://doi.org/10.1016/b978-0-12-409547-2.12291-7
https://doi.org/10.1016/b978-0-12-409547-2.12291-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3673-3682
Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have been increasingly utilized in drug discovery. In this brief review, we highlight selected examples from the primary medicinal chemistry literature during the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7352958ca0bb0ac71741527ae0d63ac1
https://doi.org/10.1016/j.bmcl.2014.06.081
https://doi.org/10.1016/j.bmcl.2014.06.081
Publikováno v:
Journal of Medicinal Chemistry. 57:7182-7205
LXRs have been of interest as targets for the treatment of atherosclerosis for over a decade. In recent years, LXR modulators have also garnered interest for potential use in the treatment of inflammation, Alzheimer's disease (AD), dermatological con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec8a49b86e9fa596979673d722983ac
https://doi.org/10.1021/jm500442z
https://doi.org/10.1021/jm500442z
Autor:
Jing Zhou, Suresh B. Singh, Colin M. Tice, Rebecca Van Orden, Guozhou Chen, Geeta Kandpal, Shi Meng, Cheng-Guo Dong, Yuri Bukhtiyarov, Paul B. Noto, Stephen D. Lotesta, Wei Zhao, Lamont Howard, Katerina Leftheris, Andrew P. Marcus, Kristi Fan, Andrew W. Hardy, Deepak S. Lala, Paula Krosky, Linghang Zhuang, Brian M. McKeever, Gerard McGeehan, Kerri Lipinski, Ya-Jun Zheng, Joan Guo, Yi Zhao, Richard Gregg, David A. Claremon, Zhongren Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(20)
Liver X receptor (LXR) agonists have been reported to lower brain amyloid beta (Aβ) and thus to have potential for the treatment of Alzheimer's disease. Structure and property based design led to the discovery of a series of orally bioavailable, bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dfa607065920889aae5780297b0a05
https://pubmed.ncbi.nlm.nih.gov/27599745
https://pubmed.ncbi.nlm.nih.gov/27599745