Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Colin Longstaff"'
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Fluorogenic thrombin generation (TG) is a global hemostasis assay that provides an overall representation of hemostasis potential. However, the accurate detection of thrombin activity in plasma may be affected by artifacts inheren
Externí odkaz:
https://doaj.org/article/a8aca791941b4f26874d39baf9ca8f78
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000338 (2019)
Both basic and translational research are continuously evolving, but the principles that underpin research integrity remain constant. These include rational, hypothesis-driven, and adequately planned and controlled science, which is carried out openl
Externí odkaz:
https://doaj.org/article/8da9cd5ed3734138bd29b252580b4e28
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170936 (2017)
Streptokinase is a virulence factor of streptococci and acts as a plasminogen activator to generate the serine protease plasmin which promotes bacterial metastasis. Streptokinase isolated from group C streptococci has been used therapeutically as a t
Externí odkaz:
https://doaj.org/article/63d8d25569b249539a1e75bca33192c9
Autor:
Boram Gu, Andris Piebalgs, Yu Huang, Colin Longstaff, Alun D. Hughes, Rongjun Chen, Simon A. Thom, Xiao Yun Xu
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 111 (2019)
Thrombolytic therapy is one of the medical procedures in the treatment of acute ischaemic stroke (AIS), whereby the tissue plasminogen activator (tPA) is intravenously administered to dissolve the obstructive blood clot. The treatment of AIS by throm
Externí odkaz:
https://doaj.org/article/94bc751907694622929341af8f92261d
Autor:
Karolin Hijazi, Yufei Wang, Carlo Scala, Simon Jeffs, Colin Longstaff, Daniel Stieh, Beth Haggarty, Guido Vanham, Dominique Schols, Jan Balzarini, Ian M Jones, James Hoxie, Robin Shattock, Charles G Kelly
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28307 (2011)
Mannose-binding C-type lectin receptors, expressed on Langerhans cells and subepithelial dendritic cells (DCs) of cervico-vaginal tissues, play an important role in HIV-1 capture and subsequent dissemination to lymph nodes. DC-SIGN has been implicate
Externí odkaz:
https://doaj.org/article/6ffdc28f18324ddeb324bcee8e41573b
Autor:
Lewis J. Hardy, Dillon Bohinc, Kara L. Bane, Samantha L. Heal, Emma Hethershaw, Majid Ali, Thomas Palmer-Dench, Richard Foster, Colin Longstaff, Thomas Renné, Evi X. Stavrou, Helen Philippou
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:814-827
Autor:
Imre Varjú, Erzsébet Tóth, Ádám Z. Farkas, Veronika J. Farkas, Erzsébet Komorowicz, Tímea Feller, Balázs Kiss, Miklós Z. Kellermayer, László Szabó, András Wacha, Attila Bóta, Colin Longstaff, Krasimir Kolev
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 20(12)
Fibrin, the main scaffold of thrombi, is susceptible to citrullination by PAD (peptidyl arginine deiminase) 4, secreted from neutrophils during the formation of neutrophil extracellular traps. Citrullinated fibrinogen (citFg) has been detected in hum
Autor:
László Szabó, Anna Tanka-Salamon, Attila Bóta, Nóra Balázs, Zoltán Varga, Colin Longstaff, Erzsébet Komorowicz, Krasimir Kolev
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:1307-1318
Background Neutrophil extracellular traps (NETs) containing DNA and histones are expelled from neutrophils in infection and thrombosis. Heparins, anticoagulant polyanions, can neutralize histones with a potential therapeutic advantage in sepsis. Poly
Autor:
Krasimir Kolev, Á. Farkas, Balázs Kiss, Imre Varjú, Deya Cherpokova, Veronika J. Farkas, Attila Bóta, Colin Longstaff, Erzsébet Komorowicz, Nicoletta Sorvillo, Tímea Feller, András Wacha, László Szabó, Denisa D. Wagner, Miklós Z. Kellermayer
Publikováno v:
Circulation Research
Publikováno v:
Vox Sanguinis
Background Prekallikrein activator (PKA) is a contaminating enzyme found in therapeutic albumin and immunoglobulin products. The level is commonly measured using methods such as that defined by the European Pharmacopoeia (Ph Eur) with traceability to