Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Colin Kleanthous"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/c2f6ed6735974fcf85caac1793601ec0
Autor:
Nicholas G. Housden, Melissa N. Webby, Edward D. Lowe, Tarick J. El-Baba, Renata Kaminska, Christina Redfield, Carol V. Robinson, Colin Kleanthous
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself
Externí odkaz:
https://doaj.org/article/6092256deab845dc8d7e5e28d0ee37c4
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Bacteria exploit a variety of attack strategies to gain dominance within ecological niches. Prominent among these are contact-dependent inhibition (CDI), type VI secretion (T6SS), and bacteriocins. The cytotoxic endpoint of these systems is
Externí odkaz:
https://doaj.org/article/304a789740cd4ead82ca00ccf351333f
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The Tol-Pal system spans the cell envelope of Gram-negative bacteria, transducing the potential energy of the proton motive force (PMF) into dissociation of the TolB-Pal complex at the outer membrane (OM), freeing the lipoprotein Pal to bind the cell
Externí odkaz:
https://doaj.org/article/8f0ba5e5bd9447c68e59efc828b53b54
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009756 (2021)
The spatial localisation of proteins is critical for most cellular function. In bacteria, this is typically achieved through capture by established landmark proteins. However, this requires that the protein is diffusive on the appropriate timescale.
Externí odkaz:
https://doaj.org/article/5f31b08355434bdf859b8c1ff3feecc7
Autor:
Joanna Szczepaniak, Peter Holmes, Karthik Rajasekar, Renata Kaminska, Firdaus Samsudin, Patrick George Inns, Patrice Rassam, Syma Khalid, Seán M. Murray, Christina Redfield, Colin Kleanthous
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The lipoprotein Pal participates in the coordination of outer-membrane constriction with septation in Gram-negative bacteria. Here, the authors show that this coordination is mediated by active mobilisation-and-capture of Pal at division septa by the
Externí odkaz:
https://doaj.org/article/2f7d24a022ee4c7a9de34a43cac7f5a3
Autor:
Ruth Cohen-Khait, Ameya Harmalkar, Phuong Pham, Melissa N. Webby, Nicholas G. Housden, Emma Elliston, Jonathan T. S. Hopper, Shabaz Mohammed, Carol V. Robinson, Jeffrey J. Gray, Colin Kleanthous
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Decades of excessive use of readily available antibiotics has generated a global problem of antibiotic resistance and, hence, an urgent need for novel antibiotic solutions. Bacteriocins are protein-based antibiotics produced by bacteria to eliminate
Externí odkaz:
https://doaj.org/article/ddb60eae05714b6dafbaa4cb0b0c7b94
Autor:
Ravit Netzer, Dina Listov, Rosalie Lipsh, Orly Dym, Shira Albeck, Orli Knop, Colin Kleanthous, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and com
Externí odkaz:
https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a
Autor:
Hannah M. Behrens, Edward D. Lowe, Joseph Gault, Nicholas G. Housden, Renata Kaminska, T. Moritz Weber, Catriona M. A. Thompson, Gaëtan L. A. Mislin, Isabelle J. Schalk, Daniel Walker, Carol V. Robinson, Colin Kleanthous
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Pyocin S5 (PyoS5) is a potent protein bacteriocin that eradicates the human pathogen Pseudomonas aeruginosa in animal infection models, but its import mechanism is poorly understood. Here, using crystallography, biophysical and biochemical a
Externí odkaz:
https://doaj.org/article/c4cebb0569384adb8c4146e840308f42
Autor:
Matthieu Chavent, Anna L. Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous, Mark S. P. Sansom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulati
Externí odkaz:
https://doaj.org/article/19638c51dad4423f8b459af3fd0c85a4