Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson’s Disease and Intervention with Turmeric

Autor: Shameemah Abrahams, Colin Kenyon, Soraya Bardien, Zuné Jansen van Rensburg

Publikováno v: Molecular Neurobiology. 58:5920-5936

Parkinson’s disease (PD) is a movement disorder associated with severe loss of mainly dopaminergic neurons in the substantia nigra. Pathological hallmarks include Lewy bodies, and loss of neuromelanin, due to degeneration of neuromelanin-containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86f4c51ad05524b69589ddda129b3b39
https://doi.org/10.1007/s12035-021-02516-5

Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D

Autor: Sam Butterworth, Stefan Knapp, Fedor Berditchevski, Colin Kenyon, Marc Lenoir, Sundaresan Rajesh, Michael Overduin, Christian Ludwig, Michael H G Tong, Darren M. McClelland, Julia A. Hubbard, Jitendra Kumar, Mark Jeeves

Publikováno v: Biomolecular NMR Assignments. 14:221-225

The CaMK subfamily of Ser/Thr kinases are regulated by calmodulin interactions with their C-terminal regions. They are exemplified by Ca2+/calmodulin dependent protein kinase 1δ which is known as CaMK1D, CaMKIδ or CKLiK. CaMK1D mediates intracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9169ec2b71ba9f8eaca227f707b188c3
https://doi.org/10.1007/s12104-020-09950-x

Author response for 'Movement of Prion-Like alpha-Synuclein along the Gut-Brain Axis in Parkinson's Disease: A Potential Target of Curcumin Treatment'

Autor: Colin Kenyon, Riaan van Coller, Shameemah Abrahams, Jonathan Carr, Soraya Bardien, Devina Chetty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16a60d63f3c09165169b29d199ad03f7
https://doi.org/10.1111/ejn.15324/v2/response1

Immunometabolism of Myeloid-Derived Suppressor Cells: Implications for Mycobacterium tuberculosis Infection and Insights from Tumor Biology

Autor: Brian S. M. Munansangu, Colin Kenyon, Gerhard Walzl, André G. Loxton, Leigh A. Kotze, Nelita du Plessis

Publikováno v: International Journal of Molecular Sciences. 23:3512

The field of immunometabolism seeks to decipher the complex interplay between the immune system and the associated metabolic pathways. The role of small molecules that can target specific metabolic pathways and subsequently alter the immune landscape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fc28e0d5c0121eb37ec18d7f156e569
https://doi.org/10.3390/ijms23073512

Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model

Autor: Fedor Berditchevski, Lubna Hashmi, Stevenson Brett W, Graziella Greco, Juliet Morgan, Alessio Atzori, Sundaresan Rajesh, Anna M. Grabowska, Divneet Kaur, Ana Varela, Alejandro Cabanillas, Huy V. Nguyen, Marc Lenoir, Sharon C. Cheetham, Greg P. Iacobini, Colin Kenyon, Christopher J. Weston, Christophe Fromont, Clare L. Box, Miguel Garzon, Brendan Leighton, D. Heulyn Jones, Jitendra Kumar, Fiona J. Sorrell, Steven P. Vickers, Sam Butterworth, C. John Harris, Paige Grant, Clara Redondo, Peter Fischer, Michael Overduin, Andreas Krämer, Vera Novitskaya, Stefan Knapp

Publikováno v: Butterworth, S & Garzon Sanz, M 2020, ' Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model ', Journal of Medicinal Chemistry, vol. 63, no. 13, pp. 6784-6801 . https://doi.org/10.1021/acs.jmedchem.9b01803
Journal of medicinal chemistry 63(13), 6784-6801 (2020). doi:10.1021/acs.jmedchem.9b01803

Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5530ea1a6282165c274343b752573f14
https://doi.org/10.1021/acs.jmedchem.9b01803