Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Colin Jaques"'
Autor:
Colin Jaques, Carrie Mason, Thaddaeus A. Webster, Brian C. Hadley, Marissa Dickson, John K Busa
Publikováno v:
Bioprocess and Biosystems Engineering. 44:127-140
The use of Raman models for glucose and phenylalanine concentrations to provide the signal for a control algorithm to continuously adjust the feed rate of two separate supplemental feeds during the fed-batch culture of a CHOK1SV GS-KO® cell line in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c4f50e41f21a7d9f6e7b77edbb46dbe
https://doi.org/10.1007/s00449-020-02429-y
https://doi.org/10.1007/s00449-020-02429-y
Chinese hamster ovary (CHO) cells are the leading mammalian cell expression platform for biotherapeutic recombinant molecules yet some proteins remain difficult to express (DTE) in this, and other, systems. In recombinant cell lines expressing DTE pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee95667e793b067e68c4521b0e570d7
Publikováno v:
Biotechnology Progress. 34:730-737
The monitoring and control of bioprocesses is of the utmost importance in order to provide a consistent, safe, and high-quality product for consumers. Current monitoring and control schemes rely on infrequent and time consuming offline sampling metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43f977d5cf41a55c2e64e537de6df8a
https://doi.org/10.1002/btpr.2633
https://doi.org/10.1002/btpr.2633
Publikováno v:
Biotechnology and bioengineering. 116(9)
Constraint based modelling methods, such as Flux Balance Analysis (FBA), have been extensively used to decipher complex, information rich -omics datasets in order to elicit system-wide behavioral patterns of cellular metabolism. FBA has been successf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510ea53c7b3e5cee7582ce68da765875
https://pubmed.ncbi.nlm.nih.gov/31112296
https://pubmed.ncbi.nlm.nih.gov/31112296
Autor:
Joanne Roobol, Gurdeep Singh, Andrew J. Racher, Jane F. Povey, Andrew Dean, Colin Jaques, Sarah Turner, Ian R. Brown, C. Mark Smales, James D. Budge, Tanya J. Knight, Robert J. Young
Publikováno v:
Data in Brief, Vol 29, Iss, Pp-(2020)
Data in Brief
Data in Brief
The data presented in this article relates to the manuscript entitled ‘Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production’, published in the Journal Meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300bb77e03a09648446f1f7f9b8c1116
https://doi.org/10.1016/j.dib.2020.105217
https://doi.org/10.1016/j.dib.2020.105217
Publikováno v:
Biotechnology progress. 34(3)
The monitoring and control of bioprocesses is of the utmost importance in order to provide a consistent, safe, and high-quality product for consumers. Current monitoring and control schemes rely on infrequent and time consuming offline sampling metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7a850795fbc2065c1f165c1b64d6974
https://pubmed.ncbi.nlm.nih.gov/29603893
https://pubmed.ncbi.nlm.nih.gov/29603893
Understanding the causes of discrepancies in pH readings of a sample can allow more robust pH control strategies to be implemented. It was found that 59.4% of differences between two offline pH measurement technologies for an historical dataset lay o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ae832ed75bc6fb94998c5e90a640c4
https://eprints.whiterose.ac.uk/116056/1/1-s2.0-S0168165617301888-main.pdf
https://eprints.whiterose.ac.uk/116056/1/1-s2.0-S0168165617301888-main.pdf
Autor:
Ruth C, Rowland-Jones, Frans, van den Berg, Andrew J, Racher, Elaine B, Martin, Colin, Jaques
Publikováno v:
Biotechnology Progress
Cell culture process development requires the screening of large numbers of cell lines and process conditions. The development of miniature bioreactor systems has increased the throughput of such studies; however, there are limitations with their use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45f4ddd1596bb0eb7361b524700660e0
https://pubmed.ncbi.nlm.nih.gov/28271638
https://pubmed.ncbi.nlm.nih.gov/28271638
Autor:
Ruth C. Rowland‐Jones, Colin Jaques
Publikováno v:
Biotechnology Progress. 35:e2740
The biopharmaceutical industry is moving toward a more quality by design (QbD) approach that seeks to increase product and process understanding and process control. Miniature bioreactor systems offer a high-throughput method enabling the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea0c24a28b4b1b403dbcf7932ed0dd0
https://doi.org/10.1002/btpr.2740
https://doi.org/10.1002/btpr.2740