Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials

Autor: Cathrine Axfors, Perrine Janiaud, Andreas M. Schmitt, Janneke van’t Hooft, Emily R. Smith, Noah A. Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta-Ampudia, Manuela Aguilar-Guisado, Farah Al-Beidh, Marissa M. Alejandria, Rachelle N. Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa AlZamrooni, Juan-Manuel Anaya, Mark Angelo C. Ang, Ismael F. Aomar, Luis E. Argumanis, Alexander Averyanov, Vladimir P. Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn B. Bonifacio, Asha C. Bowen, Abbie Bown, Carlos Cabello-Gutierrez, Bernardo Camacho, Adrian Camacho-Ortiz, Sally Campbell-Lee, Damon H. Cao, Ana Cardesa, Jose M. Carnate, German Jr. J. Castillo, Rossana Cavallo, Fazle R. Chowdhury, Forhad U. H. Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M. Climacosa, Veerle Compernolle, Carlo Francisco N. Cortez, Abel Costa Neto, Sergio D’Antico, James Daly, Franca Danielle, Joshua S. Davis, Francesco Giuseppe De Rosa, Justin T. Denholm, Claudia M. Denkinger, Daniel Desmecht, Juan C. Díaz-Coronado, Juan A. Díaz Ponce-Medrano, Anne-Françoise Donneau, Teresita E. Dumagay, Susanna Dunachie, Cecile C. Dungog, Olufemi Erinoso, Ivy Mae S. Escasa, Lise J. Estcourt, Amy Evans, Agnes L. M. Evasan, Christian J. Fareli, Veronica Fernandez-Sanchez, Claudia Galassi, Juan E. Gallo, Patricia J. Garcia, Patricia L. Garcia, Jesus A. Garcia, Mutien Garigliany, Elvira Garza-Gonzalez, Deonne Thaddeus V. Gauiran, Paula A. Gaviria García, Jose-Antonio Giron-Gonzalez, David Gómez-Almaguer, Anthony C. Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E. Hammond, Heli Harvala, Francisco M. Heralde, Jesica Herrick, Alisa M. Higgins, Thomas E. Hills, Jennifer Hines, Karin Holm, Ashraful Hoque, Eric Hoste, Jose M. Ignacio, Alexander V. Ivanov, Maike Janssen, Jeffrey H. Jennings, Vivekanand Jha, Ruby Anne N. King, Jens Kjeldsen-Kragh, Paul Klenerman, Aditya Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin-Olsson, Pierre-François Laterre, Lyn-Li Lim, Jodor Lim, Oskar Ljungquist, Jorge M. Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez-Plaza, Josephine Anne C. Lucero, Maria Lundgren, Juan Macías, Sandy C. Maganito, Anna Flor G. Malundo, Rubén D. Manrique, Paola M. Manzini, Miguel Marcos, Ignacio Marquez, Francisco Javier Martínez-Marcos, Ana M. Mata, Colin J. McArthur, Zoe K. McQuilten, Bryan J. McVerry, David K. Menon, Geert Meyfroidt, Ma. Angelina L. Mirasol, Benoît Misset, James S. Molton, Alric V. Mondragon, Diana M. Monsalve, Parastoo Moradi Choghakabodi, Susan C. Morpeth, Paul R. Mouncey, Michel Moutschen, Carsten Müller-Tidow, Erin Murphy, Tome Najdovski, Alistair D. Nichol, Henrik Nielsen, Richard M. Novak, Matthew V. N. O’Sullivan, Julian Olalla, Akin Osibogun, Bodunrin Osikomaiya, Salvador Oyonarte, Juan M. Pardo-Oviedo, Mahesh C. Patel, David L. Paterson, Carlos A. Peña-Perez, Angel A. Perez-Calatayud, Eduardo Pérez-Alba, Anastasia Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J. Price, Anne Kristine H. Quero, Md. M. Rahman, Md. S. Rahman, Mayur Ramesh, Carolina Ramírez-Santana, Magnus Rasmussen, Megan A. Rees, Eduardo Rego, Jason A. Roberts, David J. Roberts, Yhojan Rodríguez, Jesús Rodríguez-Baño, Benjamin A. Rogers, Manuel Rojas, Alberto Romero, Kathryn M. Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M. Santos, Joe Sasadeusz, Gitana Scozzari, Manu Shankar-Hari, Gorav Sharma, Thomas Snelling, Alonso Soto, Pedrito Y. Tagayuna, Amy Tang, Geneva Tatem, Luciana Teofili, Steven Y. C. Tong, Alexis F. Turgeon, Januario D. Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enriquez, Steve A. Webb, Lothar Wiese, Christian Wikén, Erica M. Wood, Gaukhar M. Yusubalieva, Kai Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens

Publikováno v: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-23 (2021)

Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to

Externí odkaz: https://doaj.org/article/6bad8c19b16b4268afed0c169d14cf14

Operationalisation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 trials in a low and lower-middle income critical care learning health system. [version 1; peer review: 2 approved]

Autor: Diptesh Aryal, Abi Beane, Arjen M. Dondorp, Cameron Green, Rashan Haniffa, Madiha Hashmi, Devachandran Jayakumar, John C. Marshall, Colin J. McArthur, Srinivas Murthy, Steven A. Webb, Subhash P. Acharya, Pramodya G. P. Ishani, Issrah Jawad, Sushil Khanal, Kanchan Koirala, Subekshya Luitel, Upulee Pabasara, Hem Raj Paneru, Ashok Kumar, Shoaib Siddiq Patel, Nagarajan Ramakrishnan, Nawal Salahuddin, Mohiuddin Shaikh, Timo Tolppa, Ishara Udayanga, Zulfiqar Umrani

Publikováno v: Wellcome Open Research, Vol 6 (2021)

The Randomized Embedded Multifactorial Adaptive Platform (REMAP-CAP) adapted for COVID-19) trial is a global adaptive platform trial of hospitalised patients with COVID-19. We describe implementation in three countries under the umbrella of the Wellc

Externí odkaz: https://doaj.org/article/cf93c17d4106418d88316392ae5d3c6c

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)

Autor: Yahya Shehabi, Ary Serpa Neto, Rinaldo Bellomo, Belinda D. Howe, Yaseen M. Arabi, Michael Bailey, Frances E. Bass, Suhaini Bin Kadiman, Colin J. McArthur, Michael C. Reade, Ian M. Seppelt, Jukka Takala, Matt P. Wise, Steve A. Webb, C. Mashonganyika, H. McKee, A. Tonks, A. Donnelly, N. Hemmings, S. O’Kane, A. Blakemore, M. Butler, K. Cowdrey, J. Dalton, E. Gilder, S. Long, L. McCarthy, S. McGuinness, R. Parke, Y. Chen, C. McArthur, R. McConnochie, L. Newby, R. Bellomo, G. Eastwood, L. Peck, H. Young, C. Boschert, J. Edington, J. Fletcher, J. Smith, K. Nand, A. Raza, T. Sara, J. Bennett-Britton, J. Bewley, V. Bodenham, L. Cole, K. Driver, L. Grimmer, L. Howie, C. Searles, K. Sweet, D. Webster, A. van Berkel, H. Connor, J. Dennett, M. van Der Graaff, S. Henderson, J. Mehrtens, K. Miller, E. Minto, A. Morris, S. Noble, K. Parker, L. Bulfin, N. Hart, K. Shepherd, S. Vij, S. Dickson, E. Elloway, C. Ferguson, R. Jackson, P. MacNaughton, M. Marner, R. Squire, S. Waddy, P. Wafer, J. Welbourne, P. Ashcroft, D. Chambler, S. Dukes, A. Harris, S. Horton, S. Sharpe, P. Williams, S. Williams, M. Bailey, E. Blazquez, D. France, R. Hutchison, A. O’Connor, G. Comadira, M. Gough, M. Tallott, M. Bastick, R. Cameron, S. Donovan, K. Ellis, A. Gaur, R. Gregory, J. Naumoff, E. Turner, M. White, K. F. J. Au, J. Fratzia, S. Treloar, C. H. Lim, Y. Maseeda, A. P. Tan, C. L. Tang, C. Y. Yong, M. Akaltan, S. Berger, D. Blaser, L. Fazlija, M. L. Jong, M. Lensch, R. Ludwig, T. Merz, K. Nettelbeck, M. Roth, M. Schafer, J. Takala, A. Wehr, D. Zacharias, R. Amran, H. N. Ashraf, N. Azmi, N. Basri, H. Burhanuddin, Y. Hadinata, A. Hamdan, S. Kadiman, A. I. Y. M. Rashid, I. N. Sabran, S. Sulaiman, I. N. Zabidi, A. Al-Dawood, M. Aljuaid, H. Al Anizi, A. Al Saeedi, Y. Arabi, M. Dbsawy, A. Deeb, M. Hegazy, I. Magdi, E. Clarey, E. Corcoran, C. Finney, C. Harris, P. Hopkins, H. Noble, L. Thompson, T. Williams, L. A. Dumlao, R. Bassam, M. A. Hassan, N. Naseem, M. H. Al-Kurdi, A. M. Al-Harthy, S. Bernard, L. Sebafundi, C. Serban, S. K. Lim, N. Mazidah, N. Saidin, N. Sjamsuddin, I. T. A. Tan, N. Zabidi, M. Brain, S. Mineall, M. Kanhere, N. Soar, N. Abd Kadir, N. H. Abdullah, R. Awang, Z. Emperan, N. S. Husin, N. I. Ismail, S. Z. Ismail, F. N. A. Mohd Khadzali, M. F. Norddin, J. Aguila, C. Bold, B. Clatworthy, A. Dias, C. Hogan, A. Kazemi, V. Lai, R. Song, A. Williams, D. Bhatia, S. Elliot, P. Galt, K. Lavrans, P. Ritchie, A. Wang, R. Gresham, J. Lowrey, K. Masters, P. Palejs, I. Seppelt, F. Symonds, L. Weisbrodt, C. Whitehead, M. Babio-Galan, V. Calder, I. Clement, A. Harrison, I. McCullagh, C. Scott, R. Bevan, S. Caniba, D. Hacking, L. Maher, M. L. Azzolini, P. Beccaria, S. Colombo, G. Landoni, C. Leggieri, C. Luca, D. Mamo, E. Moizo, G. Monti, M. Mucci, A. Zangrillo, M. Albania, S. Arora, Y. Shi, A. Abudayah, G. Almekhlafi, E. Al Amodi, S. Al Samarrai, M. Badawi, R. Cubio Caba, O. Elffaki, Y. Mandourah, J. Valerio, C. Joyce, J. Meyer, E. Saylor, B. Venkatesh, E. Venz, J. Walsham, K. Wetzig, T. M. Khoo, J. E. S. Liew, A. N. Sakthi, A. Zulkurnain, A. Bamford, C. Bergin, R. Carrera, L. Cooper, L. Despy, S. Harkett, L. Mee, E. Reeves, C. Snelson, E. Spruce, G. Cooper, R. Hodgson, D. Pearson, M. Rosbergen, M. N. Ali, N. I. Bahar, A. Ismail, W. N. W. Ismail, N. M. Samat, N. S. M. Piah, R. Abd Rahman, M. Duroux, M. Ratcliffe, T. Warhurst, U. Buehner, E. Williams, N. Jacques, L. Keating, S. Macgill, K. L. Tamang, N. Tolan, A. Walden, R. Bower, J. Cranshaw, K. Molloy, S. Pitts, J. Butler, R. Dunlop, C. Fourie, P. Jarrett, M. Lassig-Smith, A. Livermore, S. O’Donoghue, M. Reade, T. Starr, J. Stuart, L. Campbell, M. Phillips, D. Stephens, J. Thomas, D. Cooper, R. McAllister, G. Andrew, L. Barclay, H. Dawson, D. M. Griffith, D. Hope, G. Wojcik, C. McCulloch, R. Paterson, L. Ascough, C. Paisley, J. Patrick-Heselton, D. Shaw, V. Waugh, K. Williams, I. Welters, D. Barge, A. Jordan, C. MacIsaac, T. Rechnitzer, F. Bass, J. Gatward, N. Hammond, P. Janin, W. Stedman, E. Yarad, N. A. Razak, N. Dzulkipli, S. L. Jong, K. Asen, W. L. Voon, S. Liew, J. Ball, V. Barnes, C. Dalton, S. Farnell-Ward, H. Farrah, K. Maher, J. Mellinghoff, C. Ryan, P. Shirley, L. Conlon, A. Glover, I. Martin-Loeches, E. O’Toole, J. Ewan, J. Ferrier, E. Litton, S. A. Webb, W. Berry, U. Blanco Alonso, A. Bociek, S. Campos, S. Jawara, F. Hanks, A. Kelly, K. Lei, C. McKenzie, M. Ostermann, R. Wan, S. Al-Soufi, S. Leow, K. McCann, C. Reynolds, K. Brickell, C. Fahey, L. Hays, N. Hyde, A. Nichol, D. Ryan, J. Brailsford, A. Buckley, L. Forbes, T. Maguire, J. Moore, L. Murray, A. Ghosh, M. Park, S. Said, A. Visser, H. Z. Abidin, S. Ali, M. H. Hassan, S. C. Omar, W. F. W. Shukeri, D. Brealey, G. Bercades, E. Blackburn, N. Macallum, A. Macklin, J. H. Ryu, K. Tam, D. Smyth, A. Arif, C. Bassford, C. Morgan, C. Swann, G. Ward, L. Wild, A. Bone, T. Elderkin, D. Green, D. Sach, T. Salerno, N. Simpson, F. Brohi, M. Clark, L. Williams, J. Brooks, E. Cocks, J. Cole, J. Curtin, R. Davies, H. Hill, M. Morgan, N. Palmer, C. Whitton, M. Wise, P. Baskaran, M. S. Hasan, L. Y. Tham, R. Sol Cruz, D. Dinsdale, S. Edney, C. Firkin, F. FitzJohn, G. Hill, A. Hunt, S. Hurford, G. Jones, H. Judd, C. Latimer-Bell, C. Lawrence, E. Lesona, L. Navarra, Y. Robertson, H. Smellie, A. M. Vucago, P. Young, P. Clark, J. Kong, J. Ho, V. Nayyar, C. Skelly

Publikováno v: American journal of respiratory and critical care medicine.

Sedation Practice in Intensive Care Evaluation (SPICE-III) trial reported significant heterogeneity in mortality with dexmedetomidine treatment. Supplemental propofol was commonly used to achieve desirable sedation.to quantify the association of diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154889f683d29103956d396aaf7be44c
https://pubmed.ncbi.nlm.nih.gov/36215171

Could treatment with immunomodulatory agents targeting IL-1, IL-6, or JAK signalling improve outcomes in patients with severe influenza pneumonia? A systematic and narrative review

Autor: Leanne M C Hays, Melissa Black, Michael P Prunty, Srinivas Murthy, Frank L van de Veerdonk, Djillali Annane, Alexandra Binnie, Aidan Burrell, Lennie P G Derde, Anthony C Gordon, Cameron Green, Antoine Guillon, Karuna Keat, Patrick R Lawler, David C Lye, Florian B Mayr, Colin J McArthur, Danny F McAuley, Bryan J McVerry, Susan C Morpeth, Jason Phua, Mathias Pletz, Luis Felipe Reyes, Manoj Saxena, Ian Seppelt, Manu Shankar-Hari, Wendy I Sligl, Anne M Turner, Timothy M Uyeki, Gloria Vazquez-Grande, Steve A Webb, Kate Ainscough, Andrea P Haren, Thomas Hills, Alistair Nichol

Publikováno v: HRB Open Research. 5:77

Background: Influenza is a global cause of morbidity and mortality and a significant risk for a future pandemic infection. Host hyperinflammation, similar to that seen in COVID-19, may occur in response to influenza virus pneumonia, with Janus kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd71b92eb7117d8198ffe0daf057cfff
https://doi.org/10.12688/hrbopenres.13613.1

Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase

Autor: Paul J, Young, Diane M, Mackle, Michael J, Bailey, Richard W, Beasley, Victoria L, Bennett, Adam M, Deane, Glenn M, Eastwood, Simon, Finfer, Ross C, Freebairn, Edward, Litton, Natalie J, Linke, Colin J, McArthur, Shay P, McGuinness, Rakshit, Panwar, Rinaldo, Bellomo

Publikováno v: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. 19(4)

The objective of the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX) pilot phase, which included the first 100 patients of an overall sample of 1000, was to examine feasibility.Investigator-initiated, prospec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::767afffcec0b55d1094f82e026e6eb3e
https://pubmed.ncbi.nlm.nih.gov/30153789