Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Colin J. Macdonald"'
Helix N-Cap Residues Drive the Acid Unfolding That Is Essential in the Action of the Toxin Colicin A
Autor:
Geoffrey R. Moore, Andrei Soliakov, Christopher L. Johnson, Yan Huang, Helen Waller, Colin J. Macdonald, Jeremy H. Lakey, Anton P. Le Brun, Alexandra S. Solovyova
Publikováno v:
Biochemistry
Numerous bacterial toxins and other virulence factors use low pH as a trigger to convert from water-soluble to membrane-inserted states. In the case of colicins, the pore-forming domain of colicin A (ColA-P) has been shown both to undergo a clear aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4e1203ec353ee873c1e5ca83960286
https://doi.org/10.1021/acs.biochem.9b00705
https://doi.org/10.1021/acs.biochem.9b00705
Autor:
Jesús Angulo, Thomas Stockner, Eurico J. Cabrita, Colin J. Macdonald, Azmat Sohail, Fraser MacMillan, Jenny Hall, Harald H. Sitte
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Saturation-transfer difference (STD) NMR spectroscopy is a fast and versatile method which can be applied for drug-screening purposes, allowing the determination of essential ligand binding affinities (KD). Although widely employed to study soluble p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb540292d30a794b6cccb159fb1d7317
http://europepmc.org/articles/PMC7536232
http://europepmc.org/articles/PMC7536232
Autor:
Andrew J. Gates, Mahmoud A. S. Abdelhamid, Zoë A. E. Waller, Myles R. Cheesman, László Fábián, Colin J. Macdonald
Publikováno v:
Nucleic Acids Research
Previous computational studies have shown that Cu+ can act as a substitute for H+ to support formation of cytosine (C) dimers with similar conformation to the hemi-protonated base pair found in i-motif DNA. Through a range of biophysical methods, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d105ba4db271b87fc53840987d3d63
https://doi.org/10.1093/nar/gky390
https://doi.org/10.1093/nar/gky390
Autor:
Garth A. Jones, John E. O'Brien, Samy Cecioni, Colin J. Macdonald, Susan E. Matthews, Stephen H. Ashworth, Sébastien Vidal, David L. Hughes
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (17), pp.4436-4444. ⟨10.1002/chem.201705955⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (17), pp.4436-4444. ⟨10.1002/chem.201705955⟩
International audience; Calix[4]arenes are unique macrocycles that through judicious functionalisation at the lower rim can be either fixed in one of four conformations or remain conformationally flexible. Introduction of propynyl or propenyl groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf74b893cbcb1e08b6397c5e4e86cac
https://hal-udl.archives-ouvertes.fr/hal-02121302
https://hal-udl.archives-ouvertes.fr/hal-02121302
Autor:
Badri S. Rajagopal, Colin J. Macdonald, Jonathan A. R. Worrall, Geoffrey R. Moore, Tharin M. A. Blumenschein, Oliver M. Deacon, Andreas Ioannis Karsisiotis
Publikováno v:
Biomolecular NMR Assignments. 9:415-419
Human cytochrome c is a multi-functional protein with key roles in both the mitochondrial electron transfer chain and in apoptosis. In the latter, a complex formed between the mitochondrial phospholipid cardiolipin and cytochrome c is crucial for ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6936c560a946a075c396844e5d2ce81
https://doi.org/10.1007/s12104-015-9621-3
https://doi.org/10.1007/s12104-015-9621-3
Autor:
T. Moreno-Chicano, Oliver M. Deacon, Colin J. Macdonald, Andreas Ioannis Karsisiotis, Jonathan A. R. Worrall, Michael T. Wilson, Tharin M. A. Blumenschein, Geoffrey R. Moore, Michael A. Hough
Publikováno v:
Biochemistry. 56(46)
Proteins performing multiple biochemical functions are called “moonlighting proteins” or extreme multifunctional (EMF) proteins. Mitochondrial cytochrome c is an EMF protein that binds multiple partner proteins to act as a signaling molecule, tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c8b251af4a74913d1a8f15170ad36b
https://pubmed.ncbi.nlm.nih.gov/29083920
https://pubmed.ncbi.nlm.nih.gov/29083920
Publikováno v:
Biochemical and Biophysical Research Communications. 447:128-132
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates multiple antioxidants, Phase II detoxification enzymes and other cytoprotective enzymes in cells. Activation of Nrf2 is recognised as being of potential therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91117c659426f1be73e95961a01fe24
https://doi.org/10.1016/j.bbrc.2014.03.117
https://doi.org/10.1016/j.bbrc.2014.03.117
Autor:
Alexandra A. Roberts, Miriam Arbach, Chris J. Hamilton, Colin J. Macdonald, Murree Groom, Sunil V. Sharma
Publikováno v:
Chembiochem
Bacillithiol (BSH) is the major low-molecular-weight (LMW) thiol in many low-G+C Gram-positive bacteria (Firmicutes). Evidence now emerging suggests that BSH functions as an important LMW thiol in redox regulation and xenobiotic detoxification, analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5acc6ecf482c87bfbebb99b1c819e51
https://doi.org/10.1002/cbic.201300404
https://doi.org/10.1002/cbic.201300404
Autor:
Lydia Sosa-Vargas, Graham J. Tizzard, Andrew N. Cammidge, Colin J. Macdonald, Michael J. Cook, Simon J. Coles, Isabelle Chambrier
Publikováno v:
Journal of Porphyrins and Phthalocyanines. 17:511-521
The preparation of some peripherally substituted (2,3,9,10,16,17,23,24) and non-peripherally substituted (1,4,8,11,15,18,22,25) octaalkyl lead(II) phthalocyanines with different alkyl chain lengths (6, 7, 8 or 9 carbons) is described and a comparison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e965bca6b86452ede230905e35dd5a
https://doi.org/10.1142/s108842461350020x
https://doi.org/10.1142/s108842461350020x
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Journal of Visualized Experiments : JoVE
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
instname
Journal of Visualized Experiments : JoVE
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
This detailed protocol describes the new Spin Saturation Transfer Difference Nuclear Magnetic Resonance protocol (SSTD NMR), recently developed in our group to study processes of mutual-site chemical exchange that are difficult to analyze by traditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81003e644e6932acf4cb3657b6c565ec
https://doi.org/10.3791/54499
https://doi.org/10.3791/54499