Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Colin J. Dunn"'
Autor:
Douglas Decker, Kathleen A. Ready, Stephen Buxser, Louise A. Galinet, Steven M. Vroegop, Darryl L. Chapman, Colin J. Dunn, R.J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:647-662
We showed previously that a 5-halo-6-phenyl-pyrimidinone, bropirimine (PNU-54461), inhibited progression of severe experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis. In the work presented here, we examined t
Autor:
Daniel C. Bullard, James M. Mobley, James M. Justen, Laurel M. Sly, John G. Chosay, Colin J. Dunn, J. Russell Lindsey, Arthur L. Beaudet, Nigel D. Staite
Publikováno v:
The Journal of Immunology. 163:2844-2849
P-selectin plays an important role in leukocyte adherence to microvascular endothelium and is expressed in synovial tissue from patients with rheumatoid arthritis (RA). However, the contribution of P-selectin to the initiation and chronicity of joint
Autor:
Stephen Buxser, Colin J. Dunn, Douglas Decker, Steven M. Vroegop, Louise A. Galinet, Darryl L. Chapman, Kathleen A. Ready, Roger J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:391-409
In murine severe experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis (MS), we tested the efficacy of a 5-halo-6-phenyl pyrimidinone compound, bropirimine (PNU-54461). We observed that the compound
Autor:
Ronald J. Shebuski, Rita M. Sheehy, Ann L. Wiltse, J. Craig Hartman, Colin J. Dunn, James P. McGrath
Publikováno v:
Drug Delivery. 2:190-197
The objective of this investigation was to examine the ability of two diphosphonate compounds, ethylenediaminetetraacetic acid (EDTA), and D-mannitol to specifically target ischemic/infarcted myocardium. Dichloromethylenephosphonic tetraester or tetr
Autor:
Stephen T. Schlachter, Colin J. Dunn, Sharon K. Shields, Haiyan Wu, Megan Murphy, Danielle G. Aspar, Karen A. Richard, Richard A. Nugent, N. D. Staite, Louise A. Galinet
Publikováno v:
Journal of Medicinal Chemistry. 37:4449-4454
A study of the decomposition of the pyrazoline bisphosphonate ester 2 identified 3 as the sole bisphosphonate component. Evaluation in a delayed-type hypersensitivity granuloma model of chronic inflammation in mice (DTH-GRA) showed 3 to be a potent i
Publikováno v:
Bone and Mineral. 22:221-247
Summary Analyses of paw edema and histomorphometry were performed on tibio-talar joints to determine arthritic pathological responses in untreated 28-day adjuvant-induced polyarthritis (AIP) rats, and to determine the drug effect on inhibiting these
Autor:
N. D. Staite, Sharon K. Shields, Megan Murphy, Robert J. Smith, Louise A. Galinet, Colin J. Dunn, Danielle G. Aspar, Karen A. Richard, N. A. Rohloff, Richard A. Nugent, Stephen T. Schlachter
Publikováno v:
Journal of Medicinal Chemistry. 36:134-139
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-1 in ether at 22 degrees C yield pyrazoline bisphosphonate tetraethyl esters 8a-1 in moderate to good yield. These compounds were evaluated in animal models of arthritis: rat adju
Publikováno v:
Drug Development Research. 28:47-55
Diphosphonates are known to affect skeletal and soft tissue mineralization; however, several studies have shown that these compounds effectively suppress adjuvant-induced polyarthritis in the rat, reducing the edematous inflammatory component as well
Autor:
Herman W. Smith, Sharon K. Shields, Joel Morris, Roy A. Johnson, Ivan M. Richards, Bruce M. Taylor, Robert L. Griffin, Colin J. Dunn, Frank F. Sun, Donn G. Wishka
Publikováno v:
Annals of the New York Academy of Sciences. 629:274-287
Inhalation of aerosols of ovalbumin in sensitized guinea pigs produced a marked, bronchoalveolar eosinophilia 24 hr after challenge. The lung eosinophilia was not prevented by the cyclooxygenase inhibitors, indomethacin or PAF antagonists (WEB-2086 a