Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Colin J. Akerman"'
Autor:
Joshua S. Selfe, Teresa J. S. Steyn, Eran F. Shorer, Richard J. Burman, Kira M. Düsterwald, Ariel Z. Kraitzick, Ahmed S. Abdelfattah, Eric R. Schreiter, Sarah E. Newey, Colin J. Akerman, Joseph V. Raimondo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ionic driving forces provide the net electromotive force for ion movement across receptors, channels, and transporters, and are a fundamental property of all cells. In the nervous system, fast synaptic inhibition is mediated by chloride perm
Externí odkaz:
https://doaj.org/article/c0646bb3d3a84e5dae514f6b764b6a3a
Autor:
Atreyi Chakrabarty, Sarah E. Newey, Maisha M. Promi, Belinda K. Agbetiameh, Daniella Munro, Paul J. N. Brodersen, Gemma Gothard, Kashif Mahfooz, Jose P. Mengual, Vladyslav V. Vyazovskiy, Colin J. Akerman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The unfolded protein response (UPR) maintains proteostasis upon endoplasmic reticulum (ER) stress, and is initiated by a range of physiological and pathological processes. While there have been advances in developing fluorescent reporters fo
Externí odkaz:
https://doaj.org/article/611d39d613c2435f861b6b58e3b6b82c
Autor:
Matthew J. Buchan, Gemma Gothard, Kashif Mahfooz, Joram J. van Rheede, Sophie V. Avery, Alexios Vourvoukelis, Alexander Demby, Tommas J. Ellender, Sarah E. Newey, Colin J. Akerman
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114157- (2024)
Summary: The sensory cortex receives synaptic inputs from both first-order and higher-order thalamic nuclei. First-order inputs relay simple stimulus properties from the periphery, whereas higher-order inputs relay more complex response properties, p
Externí odkaz:
https://doaj.org/article/c08a7c2e98c14916811d027f1d4026d4
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106363- (2023)
Summary: Intracellular chloride and pH play fundamental roles in determining a neuron’s synaptic inhibition and excitability. Yet it has been difficult to measure changes in these ions during periods of heightened network activity, such as occur in
Externí odkaz:
https://doaj.org/article/9025d1633a5b469286b62a8748f91148
Autor:
Tommas J. Ellender, Sophie V. Avery, Kashif Mahfooz, Jakub Scaber, Alexander von Klemperer, Sophie L. Nixon, Matthew J. Buchan, Joram J. van Rheede, Aleksandra Gatti, Cameron Waites, Hania J. Pavlou, David Sims, Sarah E. Newey, Colin J. Akerman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in uter
Externí odkaz:
https://doaj.org/article/b2efc70c3ecc4ecdb9771cc841cd4f43
Autor:
Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 897-911 (2018)
Summary: Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of th
Externí odkaz:
https://doaj.org/article/de4461b1cd604cd1b890c370ecec071c
Autor:
Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman, M. Zameel Cader
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Two-pore domain K+ (K2P) channels generate K+ leak current, which serves a vital role in controlling and modulating neuronal excitability. This diverse family of K+ channels exhibit distinct expression and function across neuronal tissues. TWIK-relat
Externí odkaz:
https://doaj.org/article/bb3a76adef4b40cd8d24e45cf3894402
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Multi-layered neural architectures that implement learning require elaborate mechanisms for symmetric backpropagation of errors that are biologically implausible. Here the authors propose a simple resolution to this problem of blame assignment that w
Externí odkaz:
https://doaj.org/article/7c2d8359409f40dc8a188044a42e7c68
Autor:
Alexandru Cǎlin, Mihai Stancu, Ana-Maria Zagrean, John G. R. Jefferys, Andrei S. Ilie, Colin J. Akerman
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Current anti-epileptic medications that boost synaptic inhibition are effective in reducing several types of epileptic seizure activity. Nevertheless, these drugs can generate significant side-effects and even paradoxical responses due to the broad n
Externí odkaz:
https://doaj.org/article/4b36f912b4424017bad971bdbff653c4
Fast synaptic inhibition determines neuronal response properties in the mammalian brain and is mediated by chloride-permeable ionotropic GABA-A receptors (GABAARs). Despite their fundamental role, it is still not known how GABAARs signal in the intac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff49d9bd5f63ec87d33d8306a8c5ef04
https://doi.org/10.1101/2023.03.01.530641
https://doi.org/10.1101/2023.03.01.530641
