Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Colin Howes"'
Autor:
Nathalie Cassoux, Rania El Botty, Joanne Wilson, Emma J. Davies, Béré Diallo, Gérald Massonnet, Colin Howes, Adnan Naguez, Chloé Raymondie, Aaron Smith, Sophie Piperno-Neumann, Sergio Roman-Roman, Paul D. Smith, Fariba Nemati, Justine Fleury, Didier Decaudin
Publikováno v:
Oncotarget
The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, ba
Autor:
Amy E. M. Newman, Neil J. MacLusky, Hayley A. Wilson, Elena Choleris, Colin Howes, Cameron S. Wasson, Emily Martin
Publikováno v:
Brain research. 1729
Gonadal steroid hormones affect the organization of the brain during sensitive periods of development, resulting in sex differences in the neuroendocrine function and behaviour of the offspring. Although alterations in developmental testosterone expo
Autor:
Karen So, Christine Pattison, Stuart Mair, Mark Savage, Gabriella Mariani, Angela W. Dymond, Gill Ford, Colin Howes, Paul D. Martin
Publikováno v:
Clinical therapeutics. 38(11)
Purpose Selumetinib (AZD6244, ARRY-142886), an oral mitogen activated kinase 1/2 inhibitor, is in clinical development for the treatment of a variety of different tumor types. Herein, we report a study that determined the distribution, metabolism, an
Autor:
Marine Dubois, Béré Diallo, Didier Decaudin, Aaron Smith, Emma J. Davies, Rania El Botty, Pascale Mariani, Sophie Piperno-Neumann, Colin Howes, Justine Fleury, Fariba Nemati, Paul D. Smith, Adnan Naguez, Nathalie Cassoux, Sergio Roman Roman, Gérald Massonnet, Joanne Wilson
Publikováno v:
Cancer Research. 78:5782-5782
Purpose: The prognosis of metastatic uveal melanoma (UM) patients remains one of the worst observed in human cancers. The identification of frequently mutated GNAQ/GNA11 and the activation of MAPK signaling in UM raise the possibility of using effici
Autor:
Robin Alec Fairhurst, Joseph D. Fullerton, David Andrew Sandham, Heinz E. Moser, Mauro Zurini, Sandra Haberthuer, Darryl Brynley Jones, Mark Dodds, Julia Hatto, Gurdip Bhalay, Colin Howes, Paul Nicklin, Simon J. Watson, David Farr, Reto Naef, Irene Muller, Andrew Dunstan, Nichola J. Arnold, Nicholas James Devereux, Morris Tweed, Angela Glen, Katharine L. Turner, Beate Leuenberger, David Beer, Sylvie Gomez, Ruth Arnold, Thomas H. Keller, Stephen Paul Collingwood, Sarah Craig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2376-2379
Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE
Autor:
I Williams, Lazzaro Mazzoni, John R. Fozard, Colin Howes, Jason P. Hannon, Cedric Wolber, Bruno Tigani
Publikováno v:
British Journal of Pharmacology. 135:685-696
The bronchoconstrictor response to adenosine is markedly and selectively increased following ovalbumin (OA) challenge in actively sensitized, Brown Norway rats. We present a pharmacological analysis of the receptor mediating this response. Like adeno
Autor:
Matthew Ling, Paula Taylor, Keith Parry, Doug Ferguson, Alexander MacDonald, Sean Redmond, Howard A. Burris, Simon T. Barry, Colin Howes, Simon Smith, Young-Ho Song, Elizabeth Janet Pease, A. Hughes, Wolfram Brugger, Maureen Hattersley, Nicholas Floch, Kim Maratea, James Martin Nolan, Susan Ashton, Shenghua Wen
Publikováno v:
Cancer Research. 77:311-311
A nanoparticle formulation of AZD2811, a selective aurora kinase B inhibitor, is currently under clinical development for the treatment of both haematological and solid tumour disease. AZD2811 is the active derivative of the prodrug Barasertib (AZD11
Autor:
Sergio Roman-Roman, R. El-Botty, Didier Decaudin, Fariba Nemati, Chloé Raymondie, Aaron Smith, Paul D. Smith, Béré Diallo, Emma J. Davies, Colin Howes, Joanne Wilson, Gérald Massonnet
Publikováno v:
European Journal of Cancer. 69:S132
Autor:
John R. Fozard, Thomas H. Keller, Robin Alec Fairhurst, Alan Steward, Bernard Faller, David Bentley, Ian N. Bruce, David A. Sykes, David Beattie, John Reilly, Zhengjin Jiang, Joe Fullerton, David Beer, Christine Lewis, Frederique Loeuillet-Ritzler, Claire Hayden, Heinz E. Moser, Alexandre Trifilieff, Bernard Cuenoud, Steven J. Charlton, Lauren M. Tedaldi, Colin Howes, Elke Wissler, François Baur, Simon J. Watson, Morris Tweed, Julia Hatto, Sheila Garman, Roland Ernst, Handan He, Diana Janus, Daniel Wyss, Michelle Bradley, David Farr
Publikováno v:
Journal of medicinal chemistry. 53(9)
Following a lipophilicity-based hypothesis, an 8-hydroxyquinolinone 2-aminoindan derived series of beta(2)-adrenoceptor agonists have been prepared and evaluated for their potential as inhaled ultralong-acting bronchodilators. Determination of their
Autor:
Colin Howes, Jong M. Wasvary, Zouhair F. Stephan, Steele Ronald Edward, E.C. Yurachek, Robin Sharif
Publikováno v:
Biochemical Pharmacology. 43:1969-1974
This study was designed to determine whether the conjugation product of L-T3 with cholic acid would result in a liver-targeted compound (CGH 509A) with hypocholesterolemic (HC) activity significantly dissociable from cardiovascular (CV) and thyroxine