Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Colin H. Quinn"'
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 47, Iss , Pp 102045- (2024)
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been
Externí odkaz:
https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc
Autor:
Janet R. Julson, Colin H. Quinn, Swatika Butey, Michael H. Erwin, Raoud Marayati, Nazia Nazam, Jerry E. Stewart, Elizabeth A. Beierle
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 427 (2023)
Hepatoblastoma is the most common primary pediatric liver tumor. Children with pulmonary metastases at diagnosis experience survival rates as low as 25%. We have shown PIM kinases play a role in hepatoblastoma tumorigenesis. In this study, we assesse
Externí odkaz:
https://doaj.org/article/a3f45a9f17b6401fa93a28ebe0eb5e6e
Autor:
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely on cisplatin, as it remains the most active single agent against hepatoblastoma. Ho
Externí odkaz:
https://doaj.org/article/651d99d3286c48f987b6b07498bbc8c8
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Markert, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, David K. Crossman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101099- (2021)
Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric pa
Externí odkaz:
https://doaj.org/article/ba8c4f5263934279a3ed4ec995b89d8c
Autor:
Adele P. Williams, Evan F. Garner, Laura L. Stafman, Jamie M. Aye, Colin H. Quinn, Raoud Marayati, Jerry E. Stewart, Venkatram R. Atigadda, Elizabeth Mroczek-Musulman, Blake P. Moore, Elizabeth A. Beierle, Gregory K. Friedman
Publikováno v:
Translational Oncology, Vol 12, Iss 10, Pp 1364-1374 (2019)
PURPOSE: In spite of advances in therapy for some subtypes, group 3 medulloblastoma continues to portend a poor prognosis. A subpopulation of medulloblastoma cells expressing the cell surface marker CD133 have been posited as possible stem cell like
Externí odkaz:
https://doaj.org/article/798dcfd1d04e44b4aa17ab1120ac63b9
Autor:
Laura L. Stafman, Adele P. Williams, Raoud Marayati, Jamie M. Aye, Hooper R. Markert, Evan F. Garner, Colin H. Quinn, Shoeb B. Lallani, Jerry E. Stewart, Karina J. Yoon, Kimberly Whelan, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition than that seen with long-term passage cell lines. In the current studies, we inve
Externí odkaz:
https://doaj.org/article/ae4c4e6cac14422ea46500505cb9f16e
Autor:
Raoud Marayati, Laura V. Bownes, Laura L. Stafman, Adele P. Williams, Colin H. Quinn, Venkatram Atigadda, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100893- (2021)
Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with RA relapse. Neuroblastoma stem cell-like cancer cells (SCLCCs) are a subpopulation of cells characterized by the e
Externí odkaz:
https://doaj.org/article/e246226acc30403d9cd1e402f31f9618
The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma
Autor:
Laura V. Bownes, Janet R. Julson, Colin H. Quinn, Sara Claire Hutchins, Michael H. Erwin, Hooper R. Markert, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Jamie Aye, Karina J. Yoon, Michael Ohlmeyer, Elizabeth A. Beierle
Publikováno v:
Journal of Pediatric Surgery. 58:1145-1154
Autor:
Janet R. Julson, Colin H. Quinn, Laura V. Bownes, Sara C. Hutchins, Jerry E. Stewart, Jamie Aye, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Journal of Pediatric Surgery. 58:1155-1163
Autor:
Colin H. Quinn, Andee M. Beierle, Janet R. Julson, Michael E. Erwin, Hasan Alrefai, Hooper R. Markert, Jerry E. Stewart, Sara Claire Hutchins, Laura V. Bownes, Jamie M. Aye, Elizabeth Mroczek-Musulman, Patricia H. Hicks, Karina J. Yoon, Christopher D. Willey, Elizabeth A. Beierle
Publikováno v:
International Journal of Bioprinting.
The use of three-dimensional (3D) bioprinting has remained at the forefront of tissue engineering and has recently been employed for generating bioprinted solid tumors to be used as cancer models to test therapeutics. In pediatrics, neural crest-deri