Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Colin H. Macphee"'
Autor:
Colin H. Macphee, Xinzhong Dong, Qi Peng, Daniel V. Paone, Per Stahl Skov, Katrine Baumann, Theresa Roethke, Deborah A. Goldspink, Samuel K. Pearson, Zining Wu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionBecause MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there is currently a tremendous interest in whether MRGRPX2 could play an important role in various pruritic dermatoses such as chronic spontaneous urtic
Externí odkaz:
https://doaj.org/article/7ca26fa053aa43d89ee499f20b3dde40
Autor:
Peter W. West, Jérémy Chéret, Rajia Bahri, Orsolya Kiss, Zining Wu, Colin H. Macphee, Silvia Bulfone-Paus
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110984- (2024)
Summary: Mast cells (MCs) are tissue-resident immune cells known to degranulate in response to FcεRI crosslinking or MRGPRX2 engagement. MCs are found close to nerves, but the mechanisms that regulate this privileged localization remain unclear. Her
Externí odkaz:
https://doaj.org/article/0ebe03746b034342af49104ab4d42dd5
Autor:
Pieter H.E. Groot, Nigel J. Pearce, John W. Yates, Claire Stocker, Charles Sauermelch, Christopher P. Doe, Robert N. Willette, Alan Olzinski, Tambra Peters, Denise d'Epagnier, Kathleen O. Morasco, John A. Krawiec, Christine L. Webb, Karpagam Aravindhan, Beat Jucker, Mark Burgert, Chun Ma, Joseph P. Marino, Jon L. Collins, Colin H. Macphee, Scott K. Thompson, Michael Jaye
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2182-2191 (2005)
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions. A
Externí odkaz:
https://doaj.org/article/a93b77eb6ebb42eda0f367c3bb33cfa8
Autor:
Joel L Johnson, Yi Shi, Rose Snipes, Salim Janmohamed, Timothy E Rolfe, Bill Davis, Anthony Postle, Colin H Macphee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89034 (2014)
The aim of this study was to assess the effects of darapladib, a selective oral investigational lipoprotein-associated phospholipase A2 inhibitor, on both plasma and plaque lipoprotein-associated phospholipase A2 activity.Patients undergoing elective
Externí odkaz:
https://doaj.org/article/4f6a0d57773b45c8a3130070c50f8fba
Autor:
Bonnie C Shaddinger, Yanmei Xu, James H Roger, Colin H Macphee, Malcolm Handel, Charlotte A Baidoo, Mindy Magee, John J Lepore, Dennis L Sprecher
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83094 (2014)
We explored the theorized upregulation of platelet-activating factor (PAF)- mediated biologic responses following lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibition using human platelet aggregation studies in an in vitro experiment and in 2
Externí odkaz:
https://doaj.org/article/33d5118069104c88ade77010bd012e10
Autor:
Lars Wallentin, Pamela L. St. Jean, Moneeza K. Siddiqui, Enrique Soto-Pedre, Gwen Kennedy, Samira Bell, Colin H. Macphee, Harvey D. White, Fiona Carr, Colin N. A. Palmer, Gillian Smith, Dawn M. Waterworth, Adem Y. Dawed
Publikováno v:
Diabetologia
Aims/hypothesis Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b2b1731f2cf44bc53b3f79e225357
https://pubmed.ncbi.nlm.nih.gov/34562103
https://pubmed.ncbi.nlm.nih.gov/34562103
Autor:
Martin Brandt, Masataka Nakano, Ye Qiao, Fumiyuki Otsuka, Liang Guo, Aloke V. Finn, Renu Virmani, Frank D. Kolodgie, Hugh H. Trout, Harry R. Davis, Xiao Qing Zhao, Colin H. Macphee, Bruce A. Wasserman, Elena Ladich, Sue Krug-Gourley, Qi Cheng
Publikováno v:
Atherosclerosis. 267:78-89
Background and aims Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzymatic inflammatory biomarker primarily bound to low-density lipoprotein cholesterol, is associated with an approximate twofold increased risk of cardiovascular disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c2db0f84e7129ed07747b4515dcf3f
https://doi.org/10.1016/j.atherosclerosis.2017.10.014
https://doi.org/10.1016/j.atherosclerosis.2017.10.014
Autor:
Eric L. Goldwaser, Mary C. Kosciuk, Venkat Venkataraman, George A. Godsey, Theresa A. Freeman, Robert G. Nagele, Hao Wu, Xin Qi, Robert L. Wilensky, Nimish K. Acharya, Colin H. Macphee
Publikováno v:
Diabetes and Vascular Disease Research. 14:200-213
Using a porcine model of diabetes mellitus and hypercholesterolaemia, we previously showed that diabetes mellitus and hypercholesterolaemia is associated with a chronic increase in blood–brain barrier permeability in the cerebral cortex, leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c290eac900ef1045cab25bc98dc28d56
https://doi.org/10.1177/1479164116683149
https://doi.org/10.1177/1479164116683149
Autor:
Yoshiko Iwamoto, Ralph Weissleder, Yu-Xiang Ye, Peter Libby, Martin Brandt, Benoit Tricot, Filip K. Swirski, Ingo Hilgendorf, Matthias Nahrendorf, Colin H. Macphee, Ashley M. Fenn, Shun He, Benjamin G. Chousterman, Atsushi Anzai, Yuan Sun, Manfred Nairz
Publikováno v:
Circulation. Heart Failure
Supplemental Digital Content is available in the text.
Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disr
Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd61785fd4cdbbaa77a191bb3b426ae2
https://doi.org/10.1161/circheartfailure.115.002334
https://doi.org/10.1161/circheartfailure.115.002334
Autor:
Nimish K, Acharya, Xin, Qi, Eric L, Goldwaser, George A, Godsey, Hao, Wu, Mary C, Kosciuk, Theresa A, Freeman, Colin H, Macphee, Robert L, Wilensky, Venkat, Venkataraman, Robert G, Nagele
Publikováno v:
Diabetesvascular disease research. 14(3)
Using a porcine model of diabetes mellitus and hypercholesterolaemia, we previously showed that diabetes mellitus and hypercholesterolaemia is associated with a chronic increase in blood-brain barrier permeability in the cerebral cortex, leading to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69fc5338dc3fe54cae5263a8254e7f79
https://pubmed.ncbi.nlm.nih.gov/28301218
https://pubmed.ncbi.nlm.nih.gov/28301218