Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Colin G Nichols"'
Autor:
Conor McClenaghan, Maya A Mukadam, Jacob Roeglin, Robert C Tryon, Manfred Grabner, Anamika Dayal, Gretchen A Meyer, Colin G Nichols
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 6, Pp 1-14 (2023)
Abstract ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP‐sensitive potassium (KATP) channels. KATP channels are found thr
Externí odkaz:
https://doaj.org/article/5bc13c0117c342b5aab5c020d963a70a
Autor:
Amanda R Dicks, Grigory I Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy Steward, Wolfgang Liedtke, Colin G Nichols, Chia-Lung Wu, Farshid Guilak
Publikováno v:
eLife, Vol 12 (2023)
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hi
Externí odkaz:
https://doaj.org/article/4223b454adbc4d21a9b6aaa05a607eef
Autor:
John R Jimah, Nichole D Salinas, Monica Sala-Rabanal, Nathaniel G Jones, L David Sibley, Colin G Nichols, Paul H Schlesinger, Niraj H Tolia
Publikováno v:
eLife, Vol 5 (2016)
Apicomplexan parasites contain a conserved protein CelTOS that, in malaria parasites, is essential for traversal of cells within the mammalian host and arthropod vector. However, the molecular role of CelTOS is unknown because it lacks sequence simil
Externí odkaz:
https://doaj.org/article/0d27362f7380472ca59ba61e6e16c97f
Publikováno v:
eLife, Vol 4 (2015)
Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a
Externí odkaz:
https://doaj.org/article/bbe4fc47733448dbad55d51bdac8a126
Autor:
Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61216 (2013)
The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function. To d
Externí odkaz:
https://doaj.org/article/c7a1618d6fb14c50a604b18925695d3e
Autor:
Yu-Wen Lin, Anlong Li, Valeria Grasso, Domenica Battaglia, Antonino Crinò, Carlo Colombo, Fabrizio Barbetti, Colin G Nichols
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63758 (2013)
ATP-sensitive potassium (K(ATP)) channels are widely distributed in various tissues and cell types where they couple cell metabolism to cell excitability. Gain of channel function (GOF) mutations in the genes encoding Kir6.2 (KCNJ11) or the associate
Externí odkaz:
https://doaj.org/article/ee9f154bf7564cc08a8bd71a3bf354eb
Autor:
Sarah N Cilvik, Joy I Wang, Kory J Lavine, Keita Uchida, Angela Castro, Carolyn M Gierasch, Carla J Weinheimer, Stacey L House, Attila Kovacs, Colin G Nichols, David M Ornitz
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82979 (2013)
Fibroblast growth factors (FGFs) and their receptors are highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. However, it is not known whether cardiomyocyte-expressed FGF receptors are necessary or sufficien
Externí odkaz:
https://doaj.org/article/e3c86d1f5cca41bf88dba6cd2bbbd09f
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19393 (2011)
Cholesterol is the major sterol component of all mammalian cell plasma membranes and plays a critical role in cell function and growth. Previous studies have shown that cholesterol inhibits inward rectifier K(+) (Kir) channels, but have not distingui
Externí odkaz:
https://doaj.org/article/cb27c319562e4918ba6e3a8b25c8f0e9
Publikováno v:
PLoS Biology, Vol 8, Iss 2, p e1000315 (2010)
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable
Externí odkaz:
https://doaj.org/article/2f6ed978a6ea401e81830705f912832f
Autor:
Maria Sara Remedi, Colin G Nichols
Publikováno v:
PLoS Medicine, Vol 5, Iss 10, p e206 (2008)
Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces
Externí odkaz:
https://doaj.org/article/2a1dc60e48ce404c9e375739108e6236