Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Colin G, Brooks"'
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18475 (2011)
Comprehensive analysis of the transcription start sites of the Ly49 genes of C57BL/6 mice using the oligo-capping 5'-RACE technique revealed that the genes encoding the "missing self" inhibitory receptors, Ly49A, C, G, and I, were transcribed from mu
Externí odkaz:
https://doaj.org/article/db2578a49afb4fefb3d1b043a0487fb0
Autor:
Colin G. Brooks
Publikováno v:
Immunobiology of Natural Killer Cells ISBN: 9780429288364
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a3c457aea9ab5323a85935b133d9c27
https://doi.org/10.1201/9780429288364-11
https://doi.org/10.1201/9780429288364-11
Publikováno v:
The Journal of Immunology. 194:6068-6081
Missing self recognition of MHC class I molecules is mediated in murine species primarily through the stochastic expression of CD94/NKG2 and Ly49 receptors on NK cells. Previous studies have suggested that the stochastic expression of Ly49 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47a443686f3b2809657f5eda54169f6
https://doi.org/10.4049/jimmunol.1401450
https://doi.org/10.4049/jimmunol.1401450
Autor:
Heiko Peters, Jonathan G. Aust, Colin G. Brooks, Ralf Kist, Farhana Hussain, Geoffrey W. Butcher, Frances Gays
Publikováno v:
The Journal of Immunology. 186:2013-2023
Ly49E is an unusual member of the Ly49 family that is expressed on fetal NK cells, epithelial T cells, and NKT cells, but not on resting adult NK cells. Ly49Ebgeo/bgeo mice in which the Ly49E gene was disrupted by inserting a β-geo transgene were he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5f710f51d158fc10c293221740d14f
https://doi.org/10.4049/jimmunol.1003698
https://doi.org/10.4049/jimmunol.1003698
Autor:
Colin G. Brooks, Leina Ibrahim, William G. Kerr, Masaru Taniguchi, Kim H. T. Paraiso, Nicole Fortenbery
Publikováno v:
The Journal of Immunology. 184:5065-5074
Previously, we showed that 2B4 is a dominant inhibitory receptor in SHIP-deficient NK cells that prevents efficient cytolysis of complex targets. We show in this study that 2B4 deficiency restores homeostatic control and cytolytic function to SHIP-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bf349cc7f1275523f8722bb3ecdedd
https://doi.org/10.4049/jimmunol.0901862
https://doi.org/10.4049/jimmunol.0901862
Publikováno v:
The Journal of Immunology. 183:106-116
NKRP1 receptors were discovered more than 20 years ago, but due to a lack of appropriate reagents, our understanding of them has remained limited. Using a novel panel of mAbs that specifically recognize mouse NKRP1A, D, and F molecules, we report her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b314cce8a55b1c7439c03ac702a54a08
https://doi.org/10.4049/jimmunol.0804281
https://doi.org/10.4049/jimmunol.0804281
Autor:
Qinzhang Zhu, Matthew T. Gillespie, Colin G. Brooks, Peter Chen, Ahmad Bakur Mahmoud, Midhun J. Thomas, Mir Munir A. Rahim, James R. Carlyle, Vicky Kartsogiannis, Andrew P. Makrigiannis, Amelia Mottashed
NKR-P1B is a homodimeric type II transmembrane C-type lectinlike receptor that inhibits natural killer (NK) cell function upon interaction with its cognate C-type lectin-related ligand, Clr-b. The NKR-P1B:Clr-b interaction represents a major histocom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c901a40c2074b86bf64142a96bd48076
https://europepmc.org/articles/PMC4383798/
https://europepmc.org/articles/PMC4383798/
Autor:
Colin G. Brooks, Noriko Toyama-Sorimachi, Delyth M. Reid, Jonathan G. Aust, Philip R. Taylor, Frances Gays, Jane Falconer
Publikováno v:
The Journal of Immunology. 177:5840-5851
Using a novel mAb specific for mouse Ly49B, we report here that Ly49B, the last remaining member of the C57 Ly49 family to be characterized, is expressed at low levels on ∼1.5% of spleen cells, none which are NK cells or T cells but which instead b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98327fda7d110386592c9551a43b54df
https://doi.org/10.4049/jimmunol.177.9.5840
https://doi.org/10.4049/jimmunol.177.9.5840
Publikováno v:
The Journal of Immunology. 175:2938-2947
Mature NK cells comprise a highly diverse population of lymphocytes that express different permutations of receptors to facilitate recognition of diseased cells and perhaps pathogens themselves. Many of these receptors, such as those belonging to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfc6318c07a087a80832b4ff0b92e9d
https://doi.org/10.4049/jimmunol.175.5.2938
https://doi.org/10.4049/jimmunol.175.5.2938
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(4)
Ly49B is a potentially important immunoregulator expressed on mouse myeloid cells, and it is thus an unusual member of the wider Ly49 family whose members are ordinarily found on NK cells. Ly49B displays substantial sequence divergence from other Ly4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4161c151f4232f4307dcc9695c549e81
https://pubmed.ncbi.nlm.nih.gov/24403531
https://pubmed.ncbi.nlm.nih.gov/24403531