Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Colin F Greineder"'
Autor:
Ghasidit Pornnoppadol, Boya Zhang, Alec A Desai, Anthony Berardi, Henriette A Remmer, Peter M Tessier, Colin F Greineder
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0252558 (2021)
The identification of antibody variable regions in the heavy (VH) and light (VL) chains from hybridomas is necessary for the production of recombinant, sequence-defined monoclonal antibodies (mAbs) and antibody derivatives. This process has received
Externí odkaz:
https://doaj.org/article/2422a6f031f8494c9006d47c01d9a2c4
Autor:
Raisa Kiseleva, Colin F Greineder, Carlos H Villa, Elizabeth D Hood, Vladimir V Shuvaev, Jing Sun, Ann-Marie Chacko, Valsamma Abraham, Horace M DeLisser, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169537 (2017)
Monoclonal antibodies (mAbs) directed to extracellular epitopes of human and mouse Platelet Endothelial Cell Adhesion Molecule-1 (CD31 or PECAM-1) stimulate binding of other mAbs to distinct adjacent PECAM-1 epitopes. This effect, dubbed Collaborativ
Externí odkaz:
https://doaj.org/article/9155c748285141548f446cfe89f90dc4
Autor:
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Externí odkaz:
https://doaj.org/article/5b46ccfab9ca479b9559e7eb89df9a94
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34958 (2012)
Antibodies to platelet endothelial cell adhesion molecule-1 (PECAM-1) facilitate targeted drug delivery to endothelial cells by "vascular immunotargeting." To define the targeting quantitatively, we investigated the endothelial binding of monoclonal
Externí odkaz:
https://doaj.org/article/1bd6ddcf87c94f36979ca7459425613c
Autor:
Boya Zhang, Brendan M. McCracken, Carmen Colmenero Mahmood, Danielle Leander, Nicholas Greer, James A. Cranford, Cindy H. Hsu, Mohamad Hakam Tiba, Robert W. Neumar, Colin F. Greineder
Publikováno v:
Resuscitation Plus, Vol 16, Iss , Pp 100477- (2023)
Aim: To evaluate coagulofibrinolytic abnormalities and the effects of ART-123 (recombinant human thrombomodulin alpha) in a porcine model of cardiac arrest and prolonged cardiopulmonary resuscitation (CA/CPR). Methods: Fifteen pigs (n = 5 per group)
Externí odkaz:
https://doaj.org/article/732feef6790a421abcbd6d22a876bfa4
Autor:
Nelish S, Ardeshna, Melinda, Song, Syed N, Hyder, Kelsey A, Grace, Connor, O'Hare, William J, Schaeffer, Michael, Stover, Colin F, Greineder, Geoffrey D, Barnes
Publikováno v:
Thrombosis Research. 221:73-78
Pulmonary Embolism Response Teams (PERT) were employed at multiple institutions to bridge the gap between varied treatment options for acute PE and unclear evidence for optimal management. There is limited data regarding the impact of PERT on the use
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Donald R. Lynch, Emily N. Stringham, Boya Zhang, Ginette Balbin-Cuesta, Brian R. Curtis, Joseph S. Palumbo, Colin F. Greineder, Benjamin E. Tourdot
Publikováno v:
Blood Advances. 6:4645-4656
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)–mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platel
Autor:
Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1452-1465 (2017)
Abstract: Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusi
Externí odkaz:
https://doaj.org/article/5eaf34428b9e4bf6807c10cf61c2e8ce
Autor:
Patrick M. Glassman, Carlos H. Villa, Oscar A. Marcos-Contreras, Elizabeth D. Hood, Landis R. Walsh, Colin F. Greineder, Jacob W. Myerson, Tea Shuvaeva, Laura Puentes, Jacob S. Brenner, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Bioconjugate Chemistry. 33:1286-1294
Engineering drug delivery systems for prolonged pharmacokinetics (PK) has been an ongoing pursuit for nearly 50 years. The gold standard for PK enhancement is the coating of nanoparticles with polymers, namely polyethylene glycol (PEGylation), which