Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Colin E. WILLOUGHBY"'
Autor:
Chelsey Doyle, Breedge Callaghan, Anton W. Roodnat, Lee Armstrong, Karen Lester, David A. Simpson, Sarah D. Atkinson, Carl Sheridan, Declan J. McKenna, Colin E. Willoughby
Publikováno v:
Cells, Vol 13, Iss 12, p 1060 (2024)
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG. All current pharmacological agents targ
Externí odkaz:
https://doaj.org/article/1c09fcdb673a4b6e99c2ab2666f7101c
Autor:
Breedge Callaghan, Karen Lester, Brian Lane, Xiaochen Fan, Katarzyna Goljanek-Whysall, David A. Simpson, Carl Sheridan, Colin E. Willoughby
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Glaucoma is a complex neurodegenerative disease resulting in progressive optic neuropathy and is a leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the predominant form affecting 65.5 million people gl
Externí odkaz:
https://doaj.org/article/e362a150588a41c7a96fbb1f99eb0c20
Autor:
Kandasamy Kathirvel, Lester Karen, Ravinarayanan Haribalaganesh, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Brian Lane, David A. Simpson, Kasia Goljanek-Whysall, Carl Sheridan, Devarajan Bharanidharan, Colin E. Willoughby, Srinivasan Senthilkumari
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In the quest of identifying newer molecular targets for the management of glucocorticoid-induced ocular hypertension (GC-OHT) and glaucoma (GCG), several microarray studies have attempted to investigate the genome-wide transcriptome profilin
Externí odkaz:
https://doaj.org/article/45cf67c53c1f4538bc2c8bc176477bbb
Publikováno v:
Cells, Vol 12, Iss 18, p 2207 (2023)
An altered expression of miR-143-3p has been previously reported in prostate cancer where it is purported to play a tumor suppressor role. Evidence from other cancers suggests miR-143-3p acts as an inhibitor of epithelial-to-mesenchymal transition (E
Externí odkaz:
https://doaj.org/article/e734d982d6e3402aa4e191b2d444600c
Autor:
Ravinarayanan Haribalaganesh, Chidambaranathan Gowri Priya, Rajendrababu Sharmila, Subbaiah Krishnadas, Veerappan Muthukkaruppan, Colin E. Willoughby, Srinivasan Senthilkumari
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid
Externí odkaz:
https://doaj.org/article/f8b2cc5fcabf4d74b09ab9a8936d925b
Autor:
Anton W. Roodnat, Breedge Callaghan, Chelsey Doyle, Megan Henry, Katarzyna Goljanek-Whysall, David A. Simpson, Carl Sheridan, Sarah D. Atkinson, Colin E. Willoughby
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1693 (2022)
Pseudoexfoliation glaucoma (XFG) is an aggressive form of secondary open angle glaucoma, characterised by the production of exfoliation material and is estimated to affect 30 million people worldwide. Activation of the TGF-β pathway by TGF-β1 has b
Externí odkaz:
https://doaj.org/article/2f7290ed93f54f71b3e146662ec69552
Autor:
Michele Callea, Stefano Bignotti, Francesco Semeraro, Francisco Cammarata-Scalisi, Jinia El-Feghaly, Antonino Morabito, Vito Romano, Colin E. Willoughby
Publikováno v:
Children, Vol 9, Iss 9, p 1357 (2022)
The term ectodermal dysplasias (EDs) describes a heterogeneous group of inherited developmental disorders that affect several tissues of ectodermal origin. The most common form of EDs is hypohidrotic ectodermal dysplasia (HED), which is characterized
Externí odkaz:
https://doaj.org/article/21aaeb1e098a49159d7df0fb669187fc
Autor:
Kandasamy Kathirvel, Karen Lester, Ravinarayanan Haribalaganesh, Ramasamy Krishnadas, Veerappan Muthukkaruppan, Brian Lane, David A. Simpson, Kasia Goljanek-Whysall, Carl Sheridan, Devarajan Bharanidharan, Colin E. Willoughby, Srinivasan Senthilkumari
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/7707ca87df6d4148ad75b4e8d7333852
Publikováno v:
Biomaterials and Biosystems, Vol 1, Iss , Pp 100011- (2021)
Glaucoma is the second leading cause of irreversible blindness worldwide. Glaucoma is a progressive optic neuropathy in which permanent loss of peripheral vision results from neurodegeneration in the optic nerve head. The trabecular meshwork is respo
Externí odkaz:
https://doaj.org/article/5febe1d91e1b49e7bb2a4e44f2abc421
Autor:
Adriana I. Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N. Cooke Bailey, Colin E. Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P. Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L. Haines, Lisa S. Kearns, Caroline Hayward, Yuan Shi, Elisabeth M. van Leeuwen, Kent D. Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I. Rotter, Nicholas G. Martin, Tanja Zeller, Richard A. Mills, Emmanuelle Souzeau, Sandra E. Staffieri, Jost B. Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H. Kang, Sionne E. M. Lucas, Tien Yin Wong, Manfred E. Beutel, James F. Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G. Uitterlinden, Eranga N. Vithana, Paul J. Foster, Pirro G. Hysi, Alex W. Hewitt, Chiea Chuen Khor, Louis R. Pasquale, Grant W. Montgomery, Caroline C. W. Klaver, Tin Aung, Norbert Pfeiffer, David A. Mackey, Christopher J. Hammond, Ching-Yu Cheng, Jamie E. Craig, Yaron S. Rabinowitz, Janey L. Wiggs, Kathryn P. Burdon, Cornelia M. van Duijn, Stuart MacGregor
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare c
Externí odkaz:
https://doaj.org/article/f7334f0a8f8b42b18a3180c2a6650fb9