Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Colin E. Murdoch"'
Autor:
Vishal Musale, Colin E. Murdoch, Ayman K. Banah, Annie Hasib, Chandani K. Hennayake, Bo Dong, Chim C. Lang, David H. Wasserman, Li Kang
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101970- (2024)
Objective: Obesity increases deposition of extracellular matrix (ECM) components of cardiac tissue. Since obesity aggregates with insulin resistance and heart disease, it is imperative to determine whether the increased ECM deposition contributes to
Externí odkaz:
https://doaj.org/article/a263f7a9365d413da8217d61d8a513a5
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102879- (2024)
Summary: Organ-on-a-chip technology incorporating stem cell techniques represents a promising strategy to improve modeling of human organs. Here, we present a protocol for generating a standardized 3D placenta-on-a-chip model using trophoblast derive
Externí odkaz:
https://doaj.org/article/41efff868c7940b9829db80b5b184f4d
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109077- (2024)
Summary: Laser speckle contrast imaging (LSCI) is an important non-invasive capability for real-time imaging for tissue-perfusion assessment. Yet, the size and weight of current clinical standard LSCI instrumentation restricts usage to mainly periphe
Externí odkaz:
https://doaj.org/article/d6cab2f413444360896f4b14918bf3eb
Autor:
Agathe Lermant, Gwenaëlle Rabussier, Henriëtte L. Lanz, Lindsay Davidson, Iain M. Porter, Colin E. Murdoch
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107240- (2023)
Summary: Although recently developed placenta-on-chip systems opened promising perspectives for placental barrier modeling, they still lack physiologically relevant trophoblasts and are poorly amenable to high-throughput studies. We aimed to implemen
Externí odkaz:
https://doaj.org/article/a5843bf8b2b74ec793eae1ebf1ab0367
Autor:
Camilla Soragni, Gwenaëlle Rabussier, Henriëtte L. Lanz, Kristin M. Bircsak, Leon J. de Windt, Sebastiaan J. Trietsch, Colin E. Murdoch, Chee Ping Ng
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102488- (2022)
Reactive oxygen species (ROS) have different properties and biological functions. They contribute to cell signaling and, in excessive amounts, to oxidative stress (OS). Although ROS is pivotal in a wide number of physiological systems and pathophysio
Externí odkaz:
https://doaj.org/article/857f974442214bc5869b76984b57a033
Autor:
Minshu Wang, Colin E. Murdoch, Alison C. Brewer, Aleksandar Ivetic, Paul Evans, Ajay M. Shah, Min Zhang
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 1427-1437 (2021)
Abstract Aims Endothelial activation and inflammatory cell infiltration have important roles in the development of cardiac fibrosis induced by renin–angiotensin system activation. NADPH oxidases (Nox proteins) are expressed in endothelial cells (EC
Externí odkaz:
https://doaj.org/article/18edc8624818410abdb154fe239c79cf
Autor:
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Géraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sébastien Jacques, Colin E. Murdoch, Francisco Miralles, Céline Méhats, Daniel Vaiman
Publikováno v:
Cells, Vol 12, Iss 4, p 578 (2023)
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations. The analysis of gene expression in placental diseases (Pre-eclamps
Externí odkaz:
https://doaj.org/article/863db01e1ecc47a8854af3f05546c663
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 812 (2022)
Human pregnancy can be affected by numerous pathologies, from those which are mild and reversible to others which are life-threatening. Among these, gestational diabetes mellitus and hypertensive disorders of pregnancy with subsequent consequences st
Externí odkaz:
https://doaj.org/article/046797be2591488daf40ef88bb29866f
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 1011-1019 (2017)
Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to p
Externí odkaz:
https://doaj.org/article/01808baa0be04469aeb5a348bb245a09
Autor:
Dongqing Guo, Colin E. Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. Thi
Externí odkaz:
https://doaj.org/article/c762682505234dd990700e007aac336b