Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Colin E. J. Pritchard"'
Autor:
Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens, Kasper Mørk, Nikolaj Warming, Ulla Bismark Kullab, Marie-Louise Nibelius Skjønnemand, Michal Krystian Oklinski, Kirsten Egelund Oklinski, Luise Bolther, Lona J. Kroese, Colin E. J. Pritchard, Ivo J. Huijbers, Angelique Corthals, Mads Toft Søndergaard, Henrik Bech Kjeldal, Cecilie Fjord Morre Pedersen, John Dirk Vestergaard Nieland
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-26 (2023)
Abstract Glucose metabolism is dysregulated in Parkinson’s disease (PD) causing a shift toward the metabolism of lipids. Carnitine palmitoyl-transferase 1A (CPT1A) regulates the key step in the metabolism of long-chain fatty acids. The aim of this
Externí odkaz:
https://doaj.org/article/4f28271dbac04814bb68caccaac3aeb2
Autor:
Miguel Vizoso, Colin E. J. Pritchard, Lorenzo Bombardelli, Bram van den Broek, Paul Krimpenfort, Roderick L. Beijersbergen, Kees Jalink, Jacco van Rheenen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Achieving spatial control of gene expression is important. Here the authors report an optimised photoactivatable Cre recombinase system, doxycycline- and light-inducible Cre recombinase (DiLiCre), and generate a DiLiCre mouse line which they use for
Externí odkaz:
https://doaj.org/article/ca99867f51bf4b11a30935fbe673b977
Autor:
Tim J. W. Harmsen, Colin E. J. Pritchard, Joey Riepsaame, Henri J. van de Vrugt, Ivo J. Huijbers, Hein te Riele
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Promiscuous activity of the Streptococcus pyogenes DNA nuclease CRISPR-Cas9 can result in destruction of a successfully modified sequence obtained by templated repair of a Cas9-induced DNA double-strand break. To avoid re-cutting, additional
Externí odkaz:
https://doaj.org/article/5a302beab37f4b3db70dfe7a0b5f39e5
Autor:
Ronak Shah, Paul C. M. van den Berk, Colin E. J. Pritchard, Ji-Ying Song, Maaike Kreft, Bas Pilzecker, Heinz Jacobs
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11129 (2023)
Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were
Externí odkaz:
https://doaj.org/article/ea33ba706f4047608cf36fc06b52029f
Autor:
Jacobs, Ronak Shah, Paul C. M. van den Berk, Colin E. J. Pritchard, Ji-Ying Song, Maaike Kreft, Bas Pilzecker, Heinz
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11129
Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were
Autor:
Carmen A, Widmer, Ismar, Klebic, Natalya, Domanitskaya, Morgane, Decollogny, Denise, Howald, Myriam, Siffert, Paul, Essers, Zuzanna, Nowicka, Nadine, Stokar-Regenscheit, Marieke, van de Ven, Renske, de Korte-Grimmerink, José A, Galván, Colin E J, Pritchard, Ivo J, Huijbers, Wojciech, Fendler, Conchita, Vens, Sven, Rottenberg
Publikováno v:
Cancer research communications. 2(10)
In recent years platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response
Autor:
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Ji-Ying Song, Cor Lieftink, Matilda Ayidah, Colin E. J. Pritchard, Judith Vivié, Kathleen E. Mcgrath, Ivo J. Huijbers, Sjaak Philipsen, Marieke von Lindern, Wilbert Zwart, Roderick L. Beijersbergen, James Palis, Paul C. M. van den Berk, Heinz Jacobs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(4):e2216055120. National Academy of Sciences
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of
Autor:
Mateusz Antoszewski, Nadine Fournier, Gustavo A. Ruiz Buendía, Joao Lourenco, Yuanlong Liu, Tara Sugrue, Christelle Dubey, Marianne Nkosi, Colin E. J. Pritchard, Ivo J. Huijbers, Gabriela C. Segat, Sandra Alonso-Moreno, Elisabeth Serracanta, Laura Belver, Adolfo A. Ferrando, Giovanni Ciriello, Andrew P. Weng, Ute Koch, Freddy Radtke
Publikováno v:
Blood. 139(16)
NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landsc
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1642
Conditional alleles in genetically modified mice allow for the deletion of a gene of interest in a target tissue when combined with a tissue-specific Cre recombinase. A conditional allele is achieved by introducing LoxP sites around a critical exon,
Publikováno v:
Gene. 305(1)
Pax3, a member of the paired-class homeodomain family of transcription factors, plays an important role in embryonic development of neurepithelium and mesenchyme-derived tissues in the mouse and is an early marker for myogenic differentiation. In the