Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.

Autor: Bruno Correia, Sofia A Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, Lénia Rodrigues, Thomas R Schneider, Maria A Carrondo, Kenneth M Kaye, J Pedro Simas, Colin E McVey

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003673 (2013)

Latency-associated nuclear antigen (LANA) mediates γ2-herpesvirus genome persistence and regulates transcription. We describe the crystal structure of the murine gammaherpesvirus-68 LANA C-terminal domain at 2.2 Å resolution. The structure reveals

Externí odkaz: https://doaj.org/article/e9ab2330f422454c8330e6d4aa52cb19

In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4

Autor: J. Pedro Simas, Marta Pires de Miranda, Colin E. McVey, Kenneth M. Kaye, Ana Patrícia Quendera

Publikováno v: Journal of Virology

KSHV is a human oncogenic virus for which there is no tractable, immunocompetent animal model of infection. MuHV-4, a related rodent gammaherpesvirus, enables pathogenesis studies in mice. In latency, both viruses persist as extrachromosomal, circula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d8347912289606b860d1bf746f4e0
http://europepmc.org/articles/PMC6189500

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA

Autor: Maria Arménia Carrondo, Tania F. Custodio, J. Pedro Simas, Bruno Correia, Colin E. McVey, Maxim V. Petoukhov, Kenneth M. Kaye, Min Tan, Franceline Juillard, Rajesh Ponnusamy, Dmitri I. Svergun, Marta Pires de Miranda

Publikováno v: Nucleic Acids Research
'Nucleic Acids Research ', vol: 43, pages: 10039-10054 (2015)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nucleic acids symposium series 43(20), 10039 (2015). doi:10.1093/nar/gkv987

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/), whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba6de49b8066ed5145848304a11cac
http://europepmc.org/articles/PMC4787769

Sensing Single Mixed-Monolayer Protected Gold Nanoparticles by the alpha-Hemolysin Nanopore

Autor: James Yates, Elisa J. Campos, Colin E. McVey, Francesco Stellacci, Yann Astier, Randy P. Carney

Publikováno v: ANALYTICAL CHEMISTRY

Gold nanoparticles are widely used in various applications in fields including chemistry, engineering, biology, medicine, and electronics. These materials can be synthesized and modified with ligands containing different functional groups. Among nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47296dbabf55bb2b1660522fa8d555b

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein

Autor: Jonathan M. Grimes, Geoffrey L. Smith, Colin E. McVey, Samantha Cooray, Ron A.-J. Chen, Nicola G. A. Abrescia, Nathan W. Bartlett, M.W. Bahar, David I. Stuart

Publikováno v: The Journal of General Virology

Vaccinia virus (VACV) encodes many immunomodulatory proteins, including inhibitors of apoptosis and modulators of innate immune signalling. VACV protein N1 is an intracellular homodimer that contributes to virus virulence and was reported to inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca5a44a179703a2a57103f6edfe79c0
https://doi.org/10.1099/vir.0.82772-0