Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Colin Downey"'
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Akademický článek
Procalcitonin, C-reactive protein, neutrophil gelatinase-associated lipocalin, resistin and the APTT waveform for the early diagnosis of serious bacterial infection and prediction of outcome in critically ill children.
Autor: Maryke J Nielsen, Paul Baines, Rebecca Jennings, Sarah Siner, Ruwanthi Kolamunnage-Dona, Paul Newland, Matthew Peak, Christine Chesters, Graham Jeffers, Colin Downey, Caroline Broughton, Lynsey McColl, Jennifer Preston, Anthony McKeever, Stephane Paulus, Nigel Cunliffe, Enitan D Carrol
Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0246027 (2021)
ObjectiveBacterial Infections remains a leading cause of death in the Paediatric Intensive Care Unit (PICU). In this era of rising antimicrobial resistance, new tools are needed to guide antimicrobial use. The aim of this study was to investigate the
Externí odkaz: https://doaj.org/article/4fa3604fdacf47c5b46fc51f4ea02784
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3
Akademický článek
Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects
Autor: Margarita Pérez-Casal, Colin Downey, Beatriz Cutillas-Moreno, Mirko Zuzel, Kenji Fukudome, Cheng Hock Toh
Publikováno v: Haematologica, Vol 94, Iss 3 (2009)
Background The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate for
Externí odkaz: https://doaj.org/article/fc2fc715b8f146d9a7b7623aec77e098
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4
Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis
Autor: Julien Toh, Xiaoling Ge, Zhenxing Cheng, Weiping Yu, Simon T. Abrams, Colin Downey, Qian Yu, Cheng Hock Toh, Susan S Wang, Guozheng Wang
Publikováno v: Journal of Immunology
C-reactive protein (CRP) can increase up to 1000-fold in blood and form complexes with very low density lipoproteins (VLDL). These complexes are associated with worse outcomes for septic patients, and this suggests a potential pathological role in se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946d32674d8cb2ae730e4176f69d135
https://doi.org/10.4049/jimmunol.1900962
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6
Reply to Rappaport et al.: Anti-FXa Activity with Intermediate-Dose Thromboprophylaxis in COVID-19
Autor: Daniella McLenaghan, Manish Gautam, Tina Dutt, Colin Downey, Charlotte King, David Simcox, Hassan Burhan, Steven Lane
Publikováno v: American Journal of Respiratory and Critical Care Medicine
Dutt T, Simcox D, Downey C, McLenaghan, D, King, C, Gautam, M, Lane, S, Burhan, H, Thromboprophylaxis in COVID-19: Anti-FXa - The Missing Factor? [published online ahead of print, 2020 Jun 8]. Am J Respir Crit Care Med. 2020;10.1164/rccm.202005-1654L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dad0c985d76daa70e5a76a8c7dfb778
http://europepmc.org/articles/PMC7737584
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7
Procalcitonin and other common biomarkers do not reliably identify patients at risk for bacterial infection after congenital heart surgery
Autor: Paul Baines, Stéphane Paulus, Rebecca Jennings, S. Siner, Shane D'Souza, Enitan D. Carrol, Christine Chesters, Kent Thorburn, Rathi Guhadasan, Steven Lane, Colin Downey
Publikováno v: PEDIATRIC CRITICAL CARE MEDICINE
Objectives: Following surgery, it is difficult to distinguish a postoperative inflammatory reaction from infection. This study examined the predictive value of the biomarkers; procalcitonin, C-reactive protein, lactate, neutrophils, lymphocytes, plat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9784cd566d8ab29656549e8497d417d9
http://ora.ox.ac.uk/objects/uuid:
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9
G466(P) Performance characteristics of biomarkers of bacterial infection in children in the paediatric intensive care unit following cardiothoracic surgery
Autor: Stéphane Paulus, Rathi Guhadasan, K Thorburn, P Baines, Enitan D. Carrol, Christine Chesters, S D’Souza, Colin Downey, R Jennings
Publikováno v: Paediatric Intensive Care Society and British Association for Paediatric Nephrology.
Aims The Systemic Inflammatory Response Syndrome (SIRS) is common after cardiac surgery and cardiopulmonary bypass (CPB), leading to difficulty in distinguishing between a bacterial infection or SIRS. Early diagnosis of post-operative infection is of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea105916b1da0e3adcf0d7a6915f3f5e
https://doi.org/10.1136/archdischild-2017-313087.458
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10
Trends in ADAMTS13 Activity Testing over the Last 7 Years in a Single UK TTP Specialist Centre
Autor: Tina Dutt, Rebecca J Shaw, Kat Moss, Colin Downey, Ashley Lawrenson
Publikováno v: Blood. 132:3526-3526
Background Historically a diagnosis of thrombotic thrombocytopenic purpura (TTP) was made on autopsy. Following the identification of ADAMTS13 deficiency as central to the pathophysiology of TTP, measurement of the enzyme became a vital diagnostic to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fadabaee883938a46799425defd5299
https://doi.org/10.1182/blood-2018-99-119331
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