Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Colin D. Funk"'
Autor:
Colin D. Funk, Ali Ardakani
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the global pandemic of 2020 infecting millions and leaving over a half million dead. As a new virus, not previously in the human population, but with similarities to othe
Externí odkaz:
https://doaj.org/article/87e4047baf3140c1bfd2ee01aab7b4d9
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has entered the human population and has spread rapidly around the world in the first half of 2020 causing a global pandemic. The virus uses its spike glycoprotein receptor-bi
Externí odkaz:
https://doaj.org/article/e331ed48f34e4c7b8b740a04dd50bf20
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 122-130 (2018)
Progress in gene editing research has been accelerated by utilizing engineered nucleases in combination with induced pluripotent stem cell (iPSC) technology. Here, we report transcription activator-like effector nuclease (TALEN)-mediated reincorporat
Externí odkaz:
https://doaj.org/article/5c25580fe484488fb2b78edcd83ed99d
Autor:
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 89-101 (2018)
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids. To address the functional interchangeability of th
Externí odkaz:
https://doaj.org/article/4450a3c1881d499a884a360424200b75
Autor:
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 102-112 (2018)
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mo
Externí odkaz:
https://doaj.org/article/8f52a30ace1d45f2ac18c73e847ab6e1
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginas
Externí odkaz:
https://doaj.org/article/eae6a3ed458b46789cceae268bf9e7a9
Publikováno v:
Viruses, Vol 13, Iss 3, p 418 (2021)
The coronavirus SARS-CoV-2, which causes Coronavirus disease 2019 (COVID-19), has infected more than 100 million people globally and caused over 2.5 million deaths in just over one year since its discovery in Wuhan, China in December 2019. The pandem
Externí odkaz:
https://doaj.org/article/8b5b22061fc948038327e5117b1489bd
Autor:
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2035- (2018)
Externí odkaz:
https://doaj.org/article/bb135825914d43f09fb7f17021c72624
Autor:
Uwe J.F. Tietge, Domenico Pratico, Tao Ding, Colin D. Funk, Reeni B. Hildebrand, Theo Van Berkel, Miranda Van Eck
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 8, Pp 1604-1614 (2005)
Group IIA secretory phospholipase A2 (sPLA2) is an acute-phase protein mediating decreased plasma HDL cholesterol and increased atherosclerosis. This study investigated the impact of macrophage-specific sPLA2 overexpression on lipoprotein metabolism
Externí odkaz:
https://doaj.org/article/8139ce29a2f549659f3cd72a0c2e7769
Autor:
Keith R. Brunt, Jun Wu, Zhilin Chen, Daniel Poeckel, Ryan A. Dercho, Luis G. Melo, Colin D. Funk, Christopher A. Ward, Ren-Ke Li
Publikováno v:
Cell Transplantation, Vol 21 (2012)
The aim of this study was to evaluate the overexpression of genes central to cell survival and angiogenesis to enhance the function of human late outgrowth endothelial progenitor cells (EPCs) and their utility for infarct recovery. Ischemic myocardia
Externí odkaz:
https://doaj.org/article/a5b934dcbe354639a0702f0eca7d5263