Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Colin Chih Chien Wu"'
Autor:
Karole N D'Orazio, Colin Chih-Chien Wu, Niladri Sinha, Raphael Loll-Krippleber, Grant W Brown, Rachel Green
Publikováno v:
eLife, Vol 8 (2019)
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or
Externí odkaz:
https://doaj.org/article/c896e6bf80134f5daf948b2e20b25c38
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2428
Translation elongation is a highly choreographed process that involves substantial conformational changes of the ribosome to accommodate aminoacyl-tRNAs and traverse along the mRNA template. To capture distinct functional states of the ribosome, a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63507cb54032f634e4847c72f62cf68f
https://pubmed.ncbi.nlm.nih.gov/35171480
https://pubmed.ncbi.nlm.nih.gov/35171480
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619742
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29deb64cc45523c929df6e28678eecc
https://doi.org/10.1007/978-1-0716-1975-9_11
https://doi.org/10.1007/978-1-0716-1975-9_11
Autor:
Ibrahim M. Sabbarini, Dvir Reif, Alexander J. McQuown, Anjali R. Nelliat, Jeffrey Prince, Britnie Santiago Membreno, Colin Chih-Chien Wu, Andrew W. Murray, Vladimir Denic
Publikováno v:
Molecular Cell. 83:252-265.e13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a375e031b4bff9173baa2a45be8354
https://doi.org/10.1016/j.molcel.2022.12.012
https://doi.org/10.1016/j.molcel.2022.12.012
Autor:
Bertrand Beckert, Namit Ranjan, Daniel N. Wilson, Agnieszka A. Pochopien, Colin Chih Chien Wu, Rachel Green, Sandra Blanchet, Marina V. Rodnina
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the ribosomal A and E sites, its exact mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f380a8619fc4a7420cf13128043d8f1c
https://pubmed.ncbi.nlm.nih.gov/33555093
https://pubmed.ncbi.nlm.nih.gov/33555093
Autor:
Daniel N. Wilson, Rachel Green, Colin Chih Chien Wu, Sandra Blanchet, Marina V. Rodnina, Namit Ranjan, Bertrand Beckert, Agnieszka A. Pochopien
SummaryIn addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the A and E sites, its exact mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8200af90d728397af75b075ac107fc3
https://doi.org/10.1101/2020.07.01.182105
https://doi.org/10.1101/2020.07.01.182105
Publikováno v:
Cell
Problems arising during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality control events. However, the global cellular response to ribosome collisions has not been explored. Here, we uncover a function for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afd2e243b7f24bddbdce7d414f8cc52
https://pubmed.ncbi.nlm.nih.gov/32610081
https://pubmed.ncbi.nlm.nih.gov/32610081
Autor:
Robert Buschauer, Thomas Becker, Roland Beckmann, Rachel Green, Otto Berninghausen, Colin Chih Chien Wu, Jingdong Cheng, Laura N. Lessen, Allen R. Buskirk, Petr Tesina
Publikováno v:
EMBO J
Inhibitory codon pairs and poly(A) tracts within the translated mRNA cause ribosome stalling and reduce protein output. The molecular mechanisms that drive these stalling events, however, are still unknown. Here, we use a combination ofin vitrobioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0355a898b0a823624fba52c664eab1
https://doi.org/10.1101/755652
https://doi.org/10.1101/755652
Autor:
Karole N. D’Orazio, Niladri K. Sinha, Grant W. Brown, Raphaël Loll-Krippleber, Colin Chih Chien Wu, Rachel Green
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a sequence of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide via the Ribosome-mediated Quality control Complex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441da8b546313e0a976dd96d07cd8cad
https://doi.org/10.1101/671099
https://doi.org/10.1101/671099