Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Colin C. F. Blake"'
Autor:
Colin C. F. Blake, Hans R. Hartmann, Michael J. Broadhurst, Elizabeth Keech, David J. Bushnell, Gareth John Thomas, Cedric H. Hassall, Nigel Adams, Alan R. Stratton
Publikováno v:
ChemInform. 22
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b528e30e7498387419522dad27a9bc
https://doi.org/10.1002/chin.199108332
https://doi.org/10.1002/chin.199108332
Autor:
David J. Bushnell, Hans R. Hartmann, Elizabeth Keech, Michael J. Broadhurst, Nigel Adams, Gareth John Thomas, Colin C. F. Blake, Alan R. Stratton, Cedric H. Hassall
Publikováno v:
ChemInform. 22
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72253667830faa4509363f3eeea134e
https://doi.org/10.1002/chin.199108331
https://doi.org/10.1002/chin.199108331
Autor:
Hans R. Hartmann, Michael J. Broadhurst, Alan R. Stratton, Elizabeth Keech, David J. Bushnell, Colin C. F. Blake, Nigel Adams, Gareth John Thomas, Cedric H. Hassall
Publikováno v:
Journal of Medicinal Chemistry. 33:2375-2379
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52ef961ea830ba70a46e005daa4d0f9
https://doi.org/10.1021/jm00171a010
https://doi.org/10.1021/jm00171a010
Publikováno v:
Biochemistry. 39(43)
Amyloid-beta (Abeta) peptide deposition as fibrillar senile plaques is a key element in the pathology of Alzheimer's disease. Here we present a high-resolution structure of an Abeta amyloid fibril using magnetically aligned preparations of a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586100bcbd1a547d0e505b9b166d6b02
https://pubmed.ncbi.nlm.nih.gov/11052680
https://pubmed.ncbi.nlm.nih.gov/11052680
Autor:
Gareth John Thomas, Alan R. Stratton, Elizabeth Keech, David J. Bushnell, Nigel Adams, Colin C. F. Blake, Hans R. Hartmann, Cedric H. Hassall, Michael J. Broadhurst
Publikováno v:
Journal of medicinal chemistry. 33(9)
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a568f7300a9d2917e991fa34547f2a34
https://pubmed.ncbi.nlm.nih.gov/2391682
https://pubmed.ncbi.nlm.nih.gov/2391682
Publikováno v:
Journal of Medicinal Chemistry. 28:375-381
The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds with prealbumin, a model for the nuclear thyroid hormone receptor, have been studied with use of computer graphics and predictions made regarding relative binding affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e1b7d6c7b9a5bdddc762acbf43f5f6
https://doi.org/10.1021/jm00381a018
https://doi.org/10.1021/jm00381a018
Autor:
Eugene C. Jorgensen, Jeffrey M. Blaney, Stuart J. Oatley, Peter A. Kollman, Andrew Dearing, Jane M. Burridge, Colin C. F. Blake, Paul K. Weiner
Publikováno v:
Journal of the American Chemical Society. 104:6424-6434
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7f70446eec103126ebfd03c5c6af57
https://doi.org/10.1021/ja00387a046
https://doi.org/10.1021/ja00387a046
Publikováno v:
Journal of medicinal chemistry. 29(5)
Prealbumin is a major thyroxine binding protein in blood that has been well studied crystallographically and has also been proposed as a model for the thyroxine nuclear receptor in tissue. The high-affinity T4 binding site in prealbumin gave a linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99186fc5cb7d1b7d2fe24a1f29d70388
https://pubmed.ncbi.nlm.nih.gov/3009810
https://pubmed.ncbi.nlm.nih.gov/3009810
Publikováno v:
Chemischer Informationsdienst. 17
Prealbumin is a major thyroxine binding protein in blood that has been well studied crystallographically and has also been proposed as a model for the thyroxine nuclear receptor in tissue. The high-affinity T4 binding site in prealbumin gave a linear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63636d70df92c076b883b5d51a0d2531
https://doi.org/10.1002/chin.198638063
https://doi.org/10.1002/chin.198638063
Autor:
Jeffrey M. Blaney, Robert Langridge, Eugene C. Jorgensen, Colin C. F. Blake, Thomas E. Ferrin, Jane M. Burridge, Michael L. Connolly, Stuart J. Oatley
Publikováno v:
Journal of medicinal chemistry. 25(7)
Computer graphics modeling of the thyroxine-prealbumin complex provides a detailed picture of the interactions between thyroxine and prealbumin. A wide variety of thyroid hormone analogue-prealbumin complexes were modeled by calculating the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f53f72f6c56a29010f93a9f58692173
https://pubmed.ncbi.nlm.nih.gov/7108895
https://pubmed.ncbi.nlm.nih.gov/7108895