Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Colin C. Anderson"'
Autor:
Adeolu O. Adegoke, Govindarajan Thangavelu, Ting-Fang Chou, Marcos I. Petersen, Kiyokazu Kakugawa, Julia F. May, Kevin Joannou, Qingyang Wang, Kristofor K. Ellestad, Louis Boon, Peter A. Bretscher, Hilde Cheroutre, Mitchell Kronenberg, Troy A. Baldwin, Colin C. Anderson
Publikováno v:
Open Biology, Vol 14, Iss 10 (2024)
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expresse
Externí odkaz:
https://doaj.org/article/ee80aa7d6f9748ea95d6dd974564e83b
Autor:
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein, Harmjan R. Vos, Geert Geeven, Adeolu O. Adegoke, Anna Hoekstra, Robert M. van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C. Anderson, Ryan M. O’Connell, Martin Vaeth, John Ussher, Boudewijn M.T. Burgering, Paul J. Coffer
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112583- (2023)
Summary: Upon antigen-specific T cell receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that the generation of extramitochon
Externí odkaz:
https://doaj.org/article/942f229d67194e4a9cd020cad65978f5
Publikováno v:
Current Research in Immunology, Vol 3, Iss , Pp 37-41 (2022)
Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) in mice, a
Externí odkaz:
https://doaj.org/article/a604df6f05be4446b035a7655c47a765
Autor:
David P. Al-Adra, Govindarajan Thangavelu, Jiaxin Lin, William F.N. Chan, Kristofor K. Ellestad, Louis Boon, Colin C. Anderson
Publikováno v:
Cell Transplantation, Vol 31 (2022)
CD8 T cells play a key role in cancer immunotherapy and allograft rejection. However, it is not clear how they kill cells and tissues that do not have the agonist peptide-major histocompatibility complex (MHC) on their surface, as in the settings of
Externí odkaz:
https://doaj.org/article/37c63de87f2f4a79b9666d760e42fe0a
Autor:
Purushothaman Kuppan, Jordan Wong, Sandra Kelly, Jiaxin Lin, Jessica Worton, Chelsea Castro, Joy Paramor, Karen Seeberger, Nerea Cuesta-Gomez, Colin C. Anderson, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2201 (2023)
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) micropart
Externí odkaz:
https://doaj.org/article/16b9bbccce744ae580602897ab1613e8
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 563-572 (2020)
Simvastatin, a commonly used cholesterol‐lowering drug, inhibits the mevalonate pathway involved in the synthesis of the mitochondrial electron carrier coenzyme Q10 (CoQ10), as well as other bioenergetics substrates. The purpose of this study was t
Externí odkaz:
https://doaj.org/article/b7c09a0748534e4494793d411e38f7c3
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 520-528 (2020)
Statins have a primary indication for the reduction and management of hypercholesterolemia; however, evidence shows that statins have the ability to increase the toxicity of chemotherapeutics within cancer cells by inducing anti-proliferative, anti-m
Externí odkaz:
https://doaj.org/article/9cd9ae23887343ce905a0f4beb874176
Publikováno v:
Advances in Redox Research, Vol 2, Iss , Pp 100008- (2021)
The dithiocarbamate fungicide maneb (MB) has garnered increasing concern due to its association with Parkinson's disease (PD) and the overall negative human health effects of pesticides in agriculture. As one of several environmental toxicant models
Externí odkaz:
https://doaj.org/article/5ea9284889b8463b93a480a88f430ee7
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Stable mixed hematopoietic chimerism is a robust method for inducing donor-specific tolerance with the potential to prevent rejection of donor islets in recipients with autoimmune type-1 diabetes. However, with reduced intensity conditioning, fully a
Externí odkaz:
https://doaj.org/article/82f7a37bb7b2414e94c004fd26be10ba
Autor:
Kristofor K. Ellestad, Govindarajan Thangavelu, Yohannes Haile, Jiaxin Lin, Louis Boon, Colin C. Anderson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Lymphopenia can result from various factors, including viral infections, clinical interventions, or as a normal property of the fetal/neonatal period. T cells in a lymphopenic environment undergo lymphopenia-induced proliferation (LIP) to fill the av
Externí odkaz:
https://doaj.org/article/ee63c01693b4498a9f672bed3c594cd5