Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Colin C Collins"'
Publikováno v:
Asian Journal of Andrology, Vol 16, Iss 4, Pp 545-548 (2014)
Metastatic prostate cancer is currently incurable. Metastasis is thought to result from changes in the expression of specific metastasis-driving genes in nonmetastatic prostate cancer tissue, leading to a cascade of activated downstream genes that se
Externí odkaz:
https://doaj.org/article/ba83286acdad40c2b63bfdf5bd4b3010
Publikováno v:
Asian Journal of Andrology, Vol 16, Iss 4, Pp 515-521 (2014)
Alternative splicing (AS) is a crucial step in gene expression. It is subject to intricate regulation, and its deregulation in cancer can lead to a wide array of neoplastic phenotypes. A large body of evidence implicates splice isoforms in most if no
Externí odkaz:
https://doaj.org/article/a1c900eb5ffa4ef68871c8beabd3fd7b
Autor:
Dong Lin, Hui Xue, Yuwei Wang, Rebecca Wu, Akira Watahiki, Xin Dong, Hongwei Cheng, Alexander W Wyatt, Colin C Collins, Peter W Gout, Yuzhuo Wang
Publikováno v:
Asian Journal of Andrology, Vol 16, Iss 3, Pp 407-412 (2014)
There is a critical need for more effective therapeutic approaches for prostate cancer. Research in this area, however, has been seriously hampered by a lack of clinically relevant, experimental in vivomodels of the disease. This review particularly
Externí odkaz:
https://doaj.org/article/e05d7bcf9d7e4c3e8de69058dca71cda
A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.
Autor:
Kendric Wang, Raunak Shrestha, Alexander W Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C Collins
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103050 (2014)
Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-dru
Externí odkaz:
https://doaj.org/article/99cce34b08ca4448b564d292a3de2905
Autor:
Fan Mo, Alexander W Wyatt, Yue Sun, Sonal Brahmbhatt, Brian J McConeghy, Chunxiao Wu, Yuzhuo Wang, Martin E Gleave, Stanislav V Volik, Colin C Collins
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101431 (2014)
RNA editing modifies the sequence of primary transcripts, potentially resulting in profound effects to RNA structure and protein-coding sequence. Recent analyses of RNA sequence data are beginning to provide insights into the distribution of RNA edit
Externí odkaz:
https://doaj.org/article/dba4b5796f804a4991b6973c243dc352
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and
Externí odkaz:
https://doaj.org/article/21eadfce02d44faba347ce9052984e6d
Autor:
Abhijit Parolia, Erik Venalainen, Hui Xue, Rebecca Mather, Dong Lin, Rebecca Wu, Perla Pucci, Jason Rogalski, Joseph R. Evans, Felix Feng, Colin C. Collins, Yuzhuo Wang, Francesco Crea
Publikováno v:
Molecular Oncology, Vol 13, Iss 5, Pp 1121-1136 (2019)
Prostate cancer (PCa) is driven by the androgen receptor (AR)‐signaling axis. Hormonal therapy often mitigates PCa progression, but a notable number of cases progress to castration‐resistant PCa (CRPC). CRPC retains AR activity and is incurable.
Externí odkaz:
https://doaj.org/article/4f4d44b860634a0cb28586f9a1c33e31
Autor:
Stephen Yiu Chuen Choi, Susan L. Ettinger, Dong Lin, Hui Xue, Xinpei Ci, Noushin Nabavi, Robert H. Bell, Fan Mo, Peter W. Gout, Neil E. Fleshner, Martin E. Gleave, Colin C. Collins, Yuzhuo Wang
Publikováno v:
Cancer Medicine, Vol 7, Iss 7, Pp 3385-3392 (2018)
Abstract Development of neuroendocrine prostate cancer (NEPC) is emerging as a major problem in clinical management of advanced prostate cancer (PCa). As increasingly potent androgen receptor (AR)‐targeting antiandrogens are more widely used, PCa t
Externí odkaz:
https://doaj.org/article/09ea5c152b8e444ebb50c29d8fcb55e0
Autor:
Martin E. Gleave, Peter C. Black, Alexander W. Wyatt, Colin C. Collins, Ladan Fazli, Dong Lin, Hideyasu Matsuyama, Alberto Contreras-Sanz, Htoo Zarni Oo, Alexander Kretschmer, Neetu Saxena, Eliana Beraldi, Jeffrey Leong, Tetsutaro Hayashi, Roland Seiler, Fan Zhang, Shusuke Akamatsu, Kenjiro Imada, Yoshihisa Kawai
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1d829aa464e9a8c29efece0047fee0
https://doi.org/10.1158/1535-7163.22519353
https://doi.org/10.1158/1535-7163.22519353
Autor:
Martin E. Gleave, Peter C. Black, Alexander W. Wyatt, Colin C. Collins, Ladan Fazli, Dong Lin, Hideyasu Matsuyama, Alberto Contreras-Sanz, Htoo Zarni Oo, Alexander Kretschmer, Neetu Saxena, Eliana Beraldi, Jeffrey Leong, Tetsutaro Hayashi, Roland Seiler, Fan Zhang, Shusuke Akamatsu, Kenjiro Imada, Yoshihisa Kawai
Probes used in the PCR assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4718ff10955169bc6c694f514b4ff6d2
https://doi.org/10.1158/1535-7163.22519344
https://doi.org/10.1158/1535-7163.22519344