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Akademický článek

Apoptosis mechanisms induced by 15d-PMJ2 in HCT116 colon cancer cells: insights into CHOP10/TRB3/Akt signaling

Autor: Hussam Albassam, Daniel A. Ladin, Ahmed Elhassanny, Colin Burns, Rukiyah Van Dross-Anderson

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Agents that stimulate the endoplasmic reticulum (ER) stress pathway are being exploited pharmacologically to induce cancer cell death. Cytotoxic ER stress is typically regulated by the transcription factor, C/EBP homologous protein 10 (CHOP10). Produ

Externí odkaz: https://doaj.org/article/72c809ffbbca47c2b666798d1e7c5ddc

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Supplementary Figure 2 from Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic

Autor: Rukiyah Van Dross, Colin Burns, Li V. Yang, Timothy L. Fitzgerald, Rene Escobedo, Eman Soliman, Daniel A. Ladin

15d-PMJ2 activity in murine NMSC cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417aa9319b9e24db0cdb6564b7c92756
https://doi.org/10.1158/1535-7163.22504086

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Supplementary figure legends from Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic

Autor: Rukiyah Van Dross, Colin Burns, Li V. Yang, Timothy L. Fitzgerald, Rene Escobedo, Eman Soliman, Daniel A. Ladin

Supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b233077625a86338608a169819250e4a
https://doi.org/10.1158/1535-7163.22504083

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Supplementary Figure 1 from Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic

Autor: Rukiyah Van Dross, Colin Burns, Li V. Yang, Timothy L. Fitzgerald, Rene Escobedo, Eman Soliman, Daniel A. Ladin

Chemical structure and primary cell validation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0391a64433a834eed706e5a3f2ad4628
https://doi.org/10.1158/1535-7163.22504089.v1

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Data from Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic

Autor: Rukiyah Van Dross, Colin Burns, Li V. Yang, Timothy L. Fitzgerald, Rene Escobedo, Eman Soliman, Daniel A. Ladin

15-deoxy, Δ12,14-prostaglandin J2-ethanolamide, also known as 15-deoxy, Δ12,14-prostamide J2 (15d-PMJ2) is a novel product of the metabolism of arachidonoyl ethanolamide (AEA) by COX-2. 15d-PMJ2 preferentially induced cell death and apoptosis in tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4656ba23b3a85264319af18a3bb43f92
https://doi.org/10.1158/1535-7163.c.6537618.v1

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Calcium signaling induced by 15-deoxy-prostamide-J2 promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore

Autor: Daniel A. Ladin, Margaret M. Nelson, Estefani Cota, Catherine Colonna, Colin Burns, Jacques Robidoux, Kelsey H. Fisher-Wellman, Rukiyah Van Dross-Anderson

Publikováno v: Oncotarget. 13

Melanoma is the deadliest form of skin cancer in the US. Although immunotherapeutic checkpoint inhibitors and small-molecule kinase inhibitors have dramatically increased the survival of patients with melanoma, new or optimized therapeutic approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f8619bb6dfa7f18c7bb791e2d51f76
https://pubmed.ncbi.nlm.nih.gov/36580536

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The effect of wood ash on the properties and durability of lime mortar for repointing damp historic buildings

Autor: Heather Viles, Colin Burns, Chris Wood, Lucie Fusade

Publikováno v: Construction and Building Materials. 212

Historical evidence shows that wood ash has been used in lime mortar to help absorb moisture from masonry walls. In this study, an experimental programme was designed to assess the impact that varying the content of wood ash has on a range of propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20010544d21d4bac6b6dc538a4becdd2
http://ora.ox.ac.uk/objects/uuid:

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Prostaglandin D

Autor: Ahmed E M, Elhassanny, Daniel A, Ladin, Eman, Soliman, Hussam, Albassam, Andrew, Morris, Robert, Kobet, Kathleen, Thayne, Colin, Burns, Allison S, Danell, Rukiyah, Van Dross

Publikováno v: Prostaglandinsother lipid mediators. 142

The combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid, arachidonoyl-ethanolamide (AEA), was a potent inducer of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ad30adc0d71ef08bbdffdb080eafa71
https://pubmed.ncbi.nlm.nih.gov/30858059

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