Zobrazeno 1 - 10
of 767
pro vyhledávání: '"Colin A. Jackson"'
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1835 (2024)
Microeukaryotes are a diverse and often overlooked group of microbes that are important in food webs and other ecological linkages. Little is known about microeukaryotes associated with aquatic invertebrates, although filter feeders such as mussels a
Externí odkaz:
https://doaj.org/article/b509dcd786954dfd97996df508a5e17d
Autor:
Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3561-3574 (2023)
WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by sas16 (P450Sas) ha
Externí odkaz:
https://doaj.org/article/7d63ec27ecab4b6da2493ecc0f966b70
Autor:
Y. T. Candace Ho, Thierry Izoré, Joe A. Kaczmarski, Edward Marschall, Minuri S. Ratnayake, Julien Tailhades, David L. Steer, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Max J. Cryle
Publikováno v:
Frontiers in Catalysis, Vol 3 (2023)
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides. While adenylation domains have been well characterized due to their role
Externí odkaz:
https://doaj.org/article/024e1c8ed96e462289c72f4969cb2512
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The deazaflavin cofactor F420 is a low-potential, two-electron redox cofactor produced by some Archaea and Eubacteria that is involved in methanogenesis and methanotrophy, antibiotic biosynthesis, and xenobiotic metabolism. However, it is no
Externí odkaz:
https://doaj.org/article/32148b2317254743871f9cd92f54d262
Autor:
Madhuri Gade, Li Lynn Tan, Adam M. Damry, Mahakaran Sandhu, Joseph S. Brock, Andie Delaney, Alejandro Villar-Briones, Colin J. Jackson, Paola Laurino
Publikováno v:
JACS Au, Vol 1, Iss 12, Pp 2349-2360 (2021)
Externí odkaz:
https://doaj.org/article/2134bad111b04446ab135f33ca4dd3fe
Publikováno v:
Microorganisms, Vol 11, Iss 10, p 2489 (2023)
Freshwater mussels are important indicators of the overall health of their environment but have suffered declines that have been attributed to factors such as habitat degradation, a loss of fish hosts, climate change, and excessive nutrient inputs. T
Externí odkaz:
https://doaj.org/article/d13c56e387f341659966aeb26c6a24c7
Publikováno v:
eLife, Vol 11 (2022)
Ribonucleotide reductases (RNRs) are used by all free-living organisms and many viruses to catalyze an essential step in the de novo biosynthesis of DNA precursors. RNRs are remarkably diverse by primary sequence and cofactor requirement, while shari
Externí odkaz:
https://doaj.org/article/9f0ce5417e2e4074ab09de6438752a99
Autor:
Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provid
Externí odkaz:
https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db
Autor:
Laura Martín-Torrijos, María Martínez-Ríos, Gloria Casabella-Herrero, Susan B. Adams, Colin R. Jackson, Javier Diéguez-Uribeondo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The oomycete Aphanomyces astaci is an emerging infectious pathogen affecting freshwater crayfish worldwide and is responsible for one of the most severe wildlife pandemics ever reported. The pathogen has caused mass mortalities of freshwater
Externí odkaz:
https://doaj.org/article/85d1e3ecad6a4772821d27f58a39bd61
Autor:
Andreas Lange, Prajal H. Patel, Brennen Heames, Adam M. Damry, Thorsten Saenger, Colin J. Jackson, Geoffrey D. Findlay, Erich Bornberg-Bauer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Previous work identified goddard as a putative de novo evolved gene in Drosophila melanogaster. Here, the authors characterize the structure and function of the Goddard protein in D. melanogaster, and they infer its ancestral and extant structures ac
Externí odkaz:
https://doaj.org/article/6af27611fe4444d2b85f67d89d3f2c44