Working memory reflects vulnerability to early life adversity as a risk factor for substance use disorder in the FKBP5 cortisol cochaperone polymorphism, rs9296158.

Autor: William R Lovallo, Ashley Acheson, Andrew J Cohoon, Kristen H Sorocco, Andrea S Vincent, Colin A Hodgkinson, David Goldman

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0218212 (2019)

Early life adversity (ELA) negatively affects health behaviors in adulthood, but pathways from ELA exposure to behavioral outcomes are poorly understood. ELA in childhood and adolescence may translate into adult outcomes by way of modified glucocorti

Externí odkaz: https://doaj.org/article/8a9b4a52c3994ce6b3d72586c021b410

The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.

Autor: Jonathan Savitz, Colin A Hodgkinson, Chantal Martin-Soelch, Pei-Hong Shen, Joanna Szczepanik, Allison Nugent, Peter Herscovitch, Anthony A Grace, David Goldman, Wayne C Drevets

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54108 (2013)

Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on rewar

Externí odkaz: https://doaj.org/article/9daed35fa3314d38a4c766dcb30ef9dd

BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury.

Autor: Elham Rostami, Frank Krueger, Serguei Zoubak, Olga Dal Monte, Vanessa Raymont, Matteo Pardini, Colin A Hodgkinson, David Goldman, Mårten Risling, Jordan Grafman

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27389 (2011)

Neuronal plasticity is a fundamental factor in cognitive outcome following traumatic brain injury. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in this process. While there are many ways to me

Externí odkaz: https://doaj.org/article/9d634e8c9ab745e49c94575fa977a286

Strong and weak cross-inheritance of substance use disorders in a nationally representative sample

Autor: Veronica Wilson, Bridget F. Grant, Tulshi D. Saha, Amy Z. Fan, Abbas Parsian, David Goldman, Colin A. Hodgkinson, S. Patricia Chou, Haitao Zhang, W. June Ruan, Bradley T. Kerridge, Boji Huang, Jeesun Jung

Publikováno v: Mol Psychiatry

Substance use disorders (SUDs) are moderately to highly heritable and are in part cross-transmitted genetically, as observed in twin and family studies. We performed exome-focused genotyping to examine the cross-transmission of four SUDs: alcohol use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7318652b1d68041b00709a091f83365a
https://doi.org/10.1038/s41380-021-01370-0

Additive effects of stress and alcohol exposure on accelerated epigenetic aging in alcohol use disorder

Autor: Jeesun Jung, Daniel L. McCartney, Josephin Wagner, Joyce Yoo, Andrew S. Bell, Lucas A. Mavromatis, Daniel B. Rosoff, Colin A. Hodgkinson, Hui Sun, Melanie Schwandt, Nancy Diazgranados, Alicia K. Smith, Vasiliki Michopoulos, Abigail Powers, Jennifer Stevens, Bekh Bradley, Negar Fani, Rosie M. Walker, Archie Campbell, David J. Porteous, Andrew M. McIntosh, Steve Horvath, Riccardo E. Marioni, Kathryn L. Evans, David Goldman, Falk W. Lohoff

Publikováno v: Jung, J, McCartney, D L, Wagner, J, Yoo, J, Bell, A S, Mavromatis, L A, Rosoff, D B, Hodgkinson, C A, Sun, H, Schwandt, M, Diazgranados, N, Smith, A K, Michopoulos, V, Powers, A, Stevens, J, Bradley, B, Fani, N, Walker, R M, Campbell, A, Porteous, D J, McIntosh, A M, Horvath, S, Marioni, R E, Evans, K L, Goldman, D & Lohoff, F W 2022, ' Additive effects of stress and alcohol exposure on accelerated epigenetic aging in alcohol use disorder ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2022.06.036

BACKGROUND: Stress contributes to premature aging and susceptibility to alcohol use disorder (AUD), and AUD itself is a factor in premature aging; however, the interrelationships of stress, AUD, and premature aging are poorly understood.METHODS: We c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8f2fe3b0f569dfac4e626d27b6ad3d
https://hdl.handle.net/20.500.11820/3d3e5299-fa60-4c32-af89-8c753b4d6739